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492
datasets available to search
ShareScore release 0.9.0
Dataset results
492 results for “EGFR mutations;”
Relation between TP53 GOF mutation and Osimertinib treatment in EGFR mutant lung cancer
GEO Series GSE232890. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Eradicating Drug Tolerant Persister Cells in EGFR-Mutated Non-Small Cell Lung Cancer by Targeting TROP2 with CAR-T cellular therapy
GEO Series GSE302284. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC "
<p>This record contains raw data related to article “Uncommon single and compound EGFR mutations: clinical outcomes of a heterogeneous subgroup of NSCLC"</p> <p>Molecular characterization of non-small-cell lung cancer (NSCLC) is essential to define the correct therapeutic algorithm in metastatic disease. Approximately 90% of epidermal growth factor receptor (EGFR) mutations are usually associated with sensitivity to EGFR tyrosine kinase inhibitors (TKIs). The remaining 10% defines a small, extremely heterogeneous subgroup of mutations, with a varied profile of sensitivity and response to target therapies.This retrospective observational study includes 47 patients affected by metastatic NSCLC harboring uncommon EGFR mutations (single or compound mutation). Patients were treated with EGFR-targeting TKIs or platinum-based chemotherapy as first-line treatment.Median OS resulted longer in the compound mutation group when compared to single rare mutations (33.6 vs 12 months; P = 0.473); a similar result was observed for PFS (16 vs 7.6 months; P = 0.281), although statistical significance was not reached. ORR, PFS and OS resulted similar for patients treated with first-line EGFR TKIs or chemotherapy. No difference in terms of PFS and OS was found according to the TKI administered.Compound mutations seem to be a good prognostic indicator for OS; they are also predictive of response to 1st and 2nd generation EGFR TKIs, as well as exon 19 insertions and mutations in codon 719 of exon 18. For mutations in exon 18 (not in codon 719) and exon 20 insertions, chemotherapy seems the most effective available option. The addition of immunotherapy to chemotherapy could change this approach in the next future.</p>
An Expanded Access Protocol for Mobocertinib in Refractory Non-small Cell Lung Cancer (NSCLC) Participants With Epidermal Growth Factor Receptor (EGFR) Exon20 Insertion Mutations
ClinicalTrials.gov study NCT04535557. IPD Sharing: Not stated. Countries: 0. Publications: 0.
CD8+ T cell-1 dependent antitumor response boosted by dual blockade of PD-1 and VGFR2 following EGFR-tyrosine kinase inhibitors against lung cancer with Egfr mutation
GEO Series GSE197260. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptome reveals drug-resistance signature and immunosuppressive microenvironment in lung adenocarcinoma harboring EGFR mutation
GEO Series GSE253718. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Relation between TP53 GOF mutation and Osimertinib treatment in EGFR mutant lung cancer: ChIP-seq
GEO Series GSE253478. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
An EGFR-mutation signature reveals features of the EGFR-dependent phenotype and identifies MACC1 as an EGFR-associated regulator of MET.
GEO Series GSE31852. Homo sapiens. 124 samples. Type: Expression profiling by array.
Plasma MicroRNA alterations between EGFR-activating mutational NSCLC patients with and without primary resistance to TKI
GEO Series GSE99143. Human alphaherpesvirus 1; Human alphaherpesvirus 2; Human betaherpesvirus 6B; Homo sapiens; Human betaherpesvirus 5; Betapolyomavirus hominis; human gammaherpesvirus 4; Herpesvirus saimiri (strain 11); Human gammaherpesvirus 8; Betapolyomavirus macacae; Macacine alphaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus. 8 samples. Type: Non-coding RNA profiling by array.
Anti-BRAF mutation drug resistance enhances EGFR expression in melanomas
GEO Series GSE45649. Homo sapiens. 8 samples. Type: Methylation profiling by genome tiling array; Expression profiling by array.
dataset related to article "Carcinomatosis under control by osimertinib in EGFR and TP53 mutated lung adenocarcinoma"
<p>Radiological images of the patient (case report)</p>
Expression data for EGFR TKI resistant EGFR-mutated Cells
GEO Series GSE69181. Homo sapiens. 12 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.