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ShareScore release 0.9.0
Dataset results
568 results for “Glucose metabolism”
Berberine directly targets AKR1B10 protein to modulate lipid and glucose metabolism disorders in NAFLD
GEO Series GSE252928. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
CD36-DEFICIENT CONGENIC STRAINS SHOW IMPROVED GLUCOSE TOLERANCE AND DISTINCT SHIFTS IN METABOLIC AND TRANSCRIPTOMIC PROFILES
GEO Series GSE33597. Rattus norvegicus. 5 samples. Type: Expression profiling by array.
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of obese and lean mice.
GEO Series GSE121340. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA profiles of lean non-diabetic, obese non-diabetic as well as obese diabetic humans.
GEO Series GSE121344. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Global transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism
GEO Series GSE50398. Homo sapiens. 178 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by array.
Nrf2 regulates activation driven-expansion of CD4+T-cells by differentially modulating glucose and glutamine metabolism [ATAC-Seq]
GEO Series GSE292638. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Glucose metabolism induced chromatin remodeling in pulmonary artery endothelial cell
GEO Series GSE89788. Homo sapiens. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Expression profile of select glucose and lipid metabolic genes mediated by STIM1 knockout, or STIM1 knockout plus Snail1 overexpression in SMMC7721 cells
GEO Series GSE148129. Homo sapiens. 9 samples. Type: Expression profiling by RT-PCR.
Regulation of gene expression by glucose metabolism in mammary cell lines
GEO Series GSE59228. Homo sapiens. 16 samples. Type: Expression profiling by array.
A global differential transcriptomic profiling of Mycobacterium gilvum PYR-GCK during pyrene and glucose metabolism, using RNA seq.
GEO Series GSE44536. Mycolicibacterium gilvum PYR-GCK. 2 samples. Type: Expression profiling by high throughput sequencing.
Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures
GEO Series GSE4398. Saccharomyces cerevisiae. 20 samples. Type: Expression profiling by array.
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism: Liver RNA seq profiles of mice fed different feeding regimes.
GEO Series GSE121341. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Opposite microglial activation stages upon loss of PGRN result in reduced cerebral glucose metabolism
GEO Series GSE129709. Mus musculus. 10 samples. Type: Expression profiling by array.
miR8175 has an effect on glucose metabolism in obese mice
GEO Series GSE248220. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Ayurvedic herbal preparation supplementation does not improve metabolic health in impaired glucose tolerance subjects; observations from a randomised placebo controlled trial
GEO Series GSE164934. Homo sapiens. 26 samples. Type: Expression profiling by array.
Adenovirus promotes host cell anabolic glucose metabolism via MYC activation
GEO Series GSE52998. Homo sapiens. 6 samples. Type: Expression profiling by array.
Stimulating microglial glucose metabolism and phagocytosis for post-stroke remyelination and cognitive function recovery
GEO Series GSE175504. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
NMR based clinical metabolomics study revealed disturbed glucose-alanine metabolism in Gestational Diabetes
<p><strong>Background and Aim:</strong> Altered gluconeogenesis from alanine (i.e. glucose-alanine cycle) that increases the levels of<br> serum alanine aminotransferase (ALT) are linked to the development of type II diabetes (T2DM) [1,2]. A recent study also revealed that elevated serum ALT levels in early pregnancy are associated with the risk of subsequent development of gestational<br> diabetes mellitus (GDM) and preeclampsia in late pregnancy [3]. So based on this, we hypothesized that the circulatory<br> alanine and alanine to glucose ratio (AGR) would be altered in GDM and may serve as an indicative biomarker to improve<br> the clinical diagnosis of GDM. <strong>Methods:</strong> The circulatory levels of alanine and glucose were estimated for 50 GDM patients and 49 age matched healthy female subjects using 800 MHz NMR spectroscopy. The NMR spectra were analyzed using NMR suite of commercial software (CHENOMX). The estimated circulatory levels of alanine and glucose were used to determine the circulatory<br> AGR levels as [Alanine in µM]/[Glucose in mM] and the values are reported as Mean ± SEM (SEM is standard error in mean).<br> <strong>Results:</strong> The present study aims to compare the serum metabolic profiles of alanine (Ala) and alanine to glucose ratio (AGR)<br> between age and sex matched GDM patients (N=50; pre term =32, post term=18) and healthy normal control (NC) female<br> subjects (N=49). The comparison revealed that the circulatory levels of alanine and AGR are significantly decreased in GDM<br> patients (Ala=397.5 ± 28.12| AGR=94.65 ± 9.06) compared to NC subjects (Ala =515.1 ± 24.03 | AGR=166.3 ± 7.577) <strong>(Figure 1A and 1B)</strong>. The respective p-values for comparison of alanine and AGR found to be 0.002 (**) and <0.0001, ****). The disturbed glucose-alanine metabolic cycle in GDM patients was further corroborated through performing metabolic Pearson r correlation analysis between alanine and glucose <strong>(Figure 1C and 1D)</strong>. For NC subjects, the circulatory metabolites alanine and glucose found to be strongly correlated (r=0.61, 95% CI=0.40 to 0.76; R square =0.37) with two-tailed p-value <0.0001 (see Table depicted in <strong>Figure 1E)</strong>. Whereas for GDM subjects, the circulatory metabolites alanine and glucose found to be moderately correlated (r=0.45, 95% CI=0.19 to 0.64; R square =0.20, <strong>Fig. 1E</strong>) with two tailed p-value =0.002 suggesting that the glucose-alanine metabolic cycle is altered in GDM. Overall, the observed changes in circulatory metabolites and metabolic ratios clearly suggested that the gluconeogenesis from alanine is disturbed in GDM and this abnormal glucose-alanine metabolism is possibly associated with the development of disease and its progression.</p> <p><strong>References:</strong><br> [1] N. Sattar, O. Scherbakova, I. Ford, D.S. O'Reilly, A. Stanley, E. Forrest, P.W. MacFarlane, C.J. Packard, S.M. Cobbe, J.<br> Shepherd, Elevated alanine aminotransferase predicts new-onset type 2 diabetes independently of classical risk<br> factors, metabolic syndrome, and C-reactive protein in the west of Scotland coronary prevention study, Diabetes 53<br> (2004) 2855-2860.<br> [2] N.H. Cho, H.C. Jang, S.H. Choi, H.R. Kim, H.K. Lee, J.C. Chan, S. Lim, Abnormal liver function test predicts type 2<br> diabetes: a community-based prospective study, Diabetes care 30 (2007) 2566-2568.<br> [3] S.M. Lee, J.S. Park, Y.J. Han, W. Kim, S.H. Bang, B.J. Kim, C.W. Park, M.Y. Kim, Elevated alanine aminotransferase in<br> early pregnancy and subsequent development of gestational diabetes and preeclampsia, Journal of Korean Medical<br> Science 35 (2020)</p>
Safety and Efficacy of Converting Maintenance Kidney and Liver Transplant Recipients With Abnormal Glucose Metabolism From Tacrolimus to Cyclosporine Micro-emulsion
ClinicalTrials.gov study NCT00150085. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Study on the Effect of Bariatric Surgery on Glucose Metabolism in Chinese Obese and Type 2 Diabetes Patients
ClinicalTrials.gov study NCT05894811. IPD Sharing: NO. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.