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651 results for “autophagy”
Down-regulation of SRD5A1 induces autophagy and apoptosis in multiple myeloma
GEO Series GSE155858. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
HDAC6 and TDP-43 promote autophagy impairment in Amyotrophic Lateral Sclerosis
<p>The database includes the raw data of the article “HDAC6 and TDP-43 promote autophagy impairment in Amyotrophic Lateral Sclerosis”. Aim of this work was to investigate how TDP-43 and HDAC6 interacts, leading to the impairment of the autophagy pathway. The work was performed in both PBMCs and in transfected SH-SY5Y cells.</p> <p>The database contains the data obtained by the following evaluations: a) western blot (WB) analysis in healthy control and sporadic ALS patients PBMCs b) western blot analysis of protein involved in autophagy pathway after transfection with TDP-43 WT plasmid c) western blot analysis of protein involved in autophagy pathway after silencing of HDAC6.<span> </span></p> <p>This work provides solid evidence supporting the hypothesis that dysregulation of HDAC6 is a key factor in the disruption of the autophagy pathway previously detected in sALS PBMCs. To the best of our knowledge, we demonstrated for the first time that both excessive reduction in acetylated α-tubulin levels, due to HDAC6 overexpression, and excessive increase in acetylated α-tubulin levels, resulting from HDAC6 downregulation, lead to impairments in autophagy. These findings could be exploited as possible therapeutic target.</p>
Fig. 2. Key 1H–1H in Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Fig. 2. Key 1H–1H COSY (bold) and HMBC (red arrow) correlations for 1–8. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Autophagy Dysfunction in Hidradenitis Suppurativa
ClinicalTrials.gov study NCT05723757. IPD Sharing: NO. Countries: 0. Publications: 0.
Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial
ClinicalTrials.gov study NCT04190433. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Programmable targeted RNA degradation via dCas13d-directed chaperone-mediated autophagy (dCasCMA)
GEO Series GSE294475. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
GEO Series GSE135041. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Let-7 coordinately suppresses components of the amino acid sensing pathway to induce autophagy
GEO Series GSE60452. Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Rattus norvegicus; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Betapolyomavirus hominis. 6 samples. Type: Non-coding RNA profiling by array.
Autophagy Suppresses CD8+ T cell Anti-tumour Immunity
GEO Series GSE117757. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
BET inhibition induces synthetic lethality in BRCA2-deficient pancreatic cancer via autophagy-dependent cell death [CUT&RUN]
GEO Series GSE207296. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Autophagy inhibition impairs leukemia stem cell function in FLT3-ITD AML but has antagonistic interactions with tyrosine kinase inhibition
GEO Series GSE169750. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Autophagy is essential for cardiac morphogenesis during vertebrate development
GEO Series GSE51541. Danio rerio. 13 samples. Type: Expression profiling by array.
Imperatorin induces autophagy and G0/G1 phase arrest via PTEN-PI3K-AKT-mTOR/p21 signaling pathway in human osteosarcoma cells in vitro and in vivo
GEO Series GSE180321. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis revealed that chloroquine(CQ) intervenes nephrotoxicity of nilotinib in an autophagy-independent manner
GEO Series GSE212122. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile of human trabecular meshwork cells with silenced expression of autophagy genes Atg5 and Atg7 subjected to cyclic mechanical stretch
GEO Series GSE159793. Homo sapiens. 12 samples. Type: Expression profiling by array.
Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks [iNeurons]
GEO Series GSE308008. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice
GEO Series GSE57761. Mus musculus. 5 samples. Type: Expression profiling by array.
Role of OSGIN1 in Mediating Smoking-induced Autophagy in the Human Airway Epithelium [RNA-Seq]
GEO Series GSE76326. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
GEO Series GSE75218. Mus musculus. 16 samples. Type: Expression profiling by array.
Autophagy controls DNA accessibility to immunoglobulin variable regions and centroblast dynamics [scATAC-seq]
GEO Series GSE218050. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.