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505 results for “genome-wide association”
Genome-wide association study and transcriptome analysis discover novel genes for bacterial leaf streak resistance in rice
GEO Series GSE229200. Oryza sativa. 12 samples. Type: Expression profiling by high throughput sequencing.
Neuroblastoma Genome-Wide Association Study
Neuroblastoma is a malignancy of the developing sympathetic nervous system that most commonly affects young children and is often lethal. The etiology of this embryonal cancer is not fully understood. We therefore initiated a genome-wide association study (GWAS) in 2007 focused on neuroblastoma patients identified through the Children's Oncology Group (COG; 238 member institutions). Control patients for this study are children cared for at the Children's Hospital of Philadelphia (CHOP) without a diagnosis or family history of cancer. The study was initially designed to genotype 5,000 neuroblastoma cases and 10,000 controls and is powered to detect common susceptibility variants in Caucasian and African American patients. Whole genome genotyping was performed on multiple versions of Illumina SNP arrays. This version of the study represents the complete set of cases genotyped.
Genome-Wide Association Study of Relapse of Childhood Acute Lymphoblastic Leukemia
Using risk-directed therapy for childhood acute lymphoblastic leukemia (ALL), outcome has improved dramatically in the last 40 years. However, a substantial portion of patients experience relapse, many of whom have no known risk factors. Taking a genome-wide approach, we sought to evaluate the relationships between germline SNP genotypes and the risk of relapse in 2,535 children with newly diagnosed ALL after adjusting for genetic ancestry and treatment regimen. We examine prognostic value of selected SNPs in the context of known relapse risk factors (molecular subtypes, minimal residual disease, age and leukocyte count at diagnosis). Associations of relapse-related SNPs with pharmacokinetic and pharmacodynamics of antileukemic drugs offer plausible mechanism by which they are linked to treatment outcome. Finally, we aim to identify SNPs that are related to both genetic ancestry and relapse which are likely to contribute to racial disparities in ALL survival.
A Genome-Wide Association Study (GWAS) of Risk for Osteosarcoma
This is a genome-wide association study (GWAS) of osteosarcoma, the most common primary bone malignancy. Osteosarcoma typically occurs in adolescents and young adults. It occurs at increased frequency in several inherited cancer predisposition syndromes but the genetic contribution to sporadic osteosarcoma is largely unexplored. The objective of this study was to identify genetic risk factors for osteosarcoma by conducting a genome-wide association study. We developed collaborations with multiple institutions in order to attain the necessary sample size required to discover novel loci in the genome associated with osteosarcoma using the GWAS approach. Genomic DNA (either blood or buccal in source) derived from osteosarcoma cases was obtained from each participating institution or research group. De-identified blood or buccal cell DNA samples from osteosarcoma cases were derived from existing biobanks at the collaborative institutions. Control subjects were derived from existing NCI cohorts and matched by gender and ethnicity.
Single-cell genome-wide association reveals a nonsynonymous variant in ERAP1 confers increased susceptibility to influenza virus
GEO Series GSE205796. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide DNA methylation profiles of liver tissue samples obtained from patients with metabolic dysfunction-associated steatohepatitis (MASH), with or without hepatocellular carcinoma
GEO Series GSE304513. Homo sapiens. 41 samples. Type: Methylation profiling by genome tiling array.
Genome-wide study the fruit ripening associated lncRNAs in strawberry
GEO Series GSE129032. Fragaria vesca. 18 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide repetitive element expression associated with the tumor suppressor gene p53
GEO Series GSE278889. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide association study and transcriptome analysis provide new insights into the white/red earlobe color formation in chicken
GEO Series GSE110145. Gallus gallus. 200 samples. Type: Genome variation profiling by high throughput sequencing.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype
GEO Series GSE141994. Homo sapiens. 51 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Genome-wide association of Sus1 with RNAPII and tRNA genes depends on the distinctive SAGA subunits Spt8 and Spt7
GEO Series GSE65883. Saccharomyces cerevisiae. 12 samples. Type: Expression profiling by genome tiling array.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [MeRIP-seq]
GEO Series GSE141993. Homo sapiens. 4 samples. Type: Other.
Genome-wide AR chromatin association in human lung adenocarcinoma cancer cells
GEO Series GSE184311. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide association study of RegX3 in M. tuberculosis (Mtb) grown under phosphate limited conditions
GEO Series GSE182669. Mycobacterium tuberculosis. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide association study on Tuberculosis in the Chinese Population
GEO Series GSE83397. Homo sapiens. 1008 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Genome-wide binding of posterior HOXA/D transcription factors reveals subgrouping and association with CTCF
GEO Series GSE86089. Gallus gallus. 60 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide transcript profiling associated with metabolic regulation of Poplar N storage and cycling
GEO Series GSE29303. Populus trichocarpa; Populus sp.. 48 samples. Type: Expression profiling by array.
m6A independent genome-wide METTL3 and METTL14 redistribution drives senescence-associated secretory phenotype [ChIP-seq]
GEO Series GSE141992. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide association analysis and genome resequencing reveal a genomic duplication possibly concerning a novel chicken comb morphology
GEO Series GSE145948. Gallus gallus. 36 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
COCA-seq: genome-wide mapping of O-GlcNAc-associated open chromatin
GEO Series GSE294152. Homo sapiens. 4 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.