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ShareScore release 0.9.0
Dataset results
496 results for “metabolic activity”
Environmental monobutyl phthalate exposure promotes liver cancer via reprogramming cholesterol metabolism and activation of the IRE1α-XBP1s pathway
GEO Series GSE248562. Homo sapiens. 25 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C [RNA-seq]
GEO Series GSE289966. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
MYC couples SWI/SNF and metabolic reprogramming to sustain minimal residual disease in mTORC1-activated cancer cells [CUT&RUN, ATAC-seq]
GEO Series GSE270774. Homo sapiens; Mus musculus. 32 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Histone lactylation couples cellular metabolism with the activation of developmental gene regulatory networks [SOX9 MO ATAC-seq]
GEO Series GSE228341. Gallus gallus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Diclofenac inhibits esophageal squamous cell carcinoma through suppression of metabolic pathways and activation of p53 signaling
GEO Series GSE227127. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Microbiome-dependent tryptophan metabolism suppresses inflammatory immunity in the pancreatic tumor microenvironment by activation of the aryl hydrocarbon receptor
GEO Series GSE171603. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Histone lactylation couples cellular metabolism with the activation of developmental gene regulatory networks [R-GNE-140 ATAC-seq]
GEO Series GSE228342. Gallus gallus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Glutathione enhances antitumor activity of NK cells via modulation of mitochondrial metabolism in acute leukemia patients
GEO Series GSE281768. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Dihydrofolate reductase metabolic activity controls neurogenic transitions in the developing human and mouse neocortex
GEO Series GSE206408. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Metabolic licensing of quiescent glioblastoma activation and immune evasion via astrocyte-mitochondria shuttle
GEO Series GSE294545. Homo sapiens. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Choline metabolism drives metastasis in BRCA1-deficient ovarian cancers by activating FAM3C [ChIP-seq]
GEO Series GSE289967. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Bioengineering the metabolic network of CAR T-cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity
Open the record for dataset details and reuse information.
Composition and metabolic activity of the intestinal microbiota in obese children and adolescents
<p>The intestinal microbiota, according to modern data, is a “metabolic organ". Scientists distinguish a bidirectional "gut-brain" axis, the connection between the components of which is carried out thanks to intestinal microbiota and its metabolites (dopamine, short-chain fatty acids, etc.). Currently, scientific data continue to accumulate actively, studying the relationship of intestinal microbiota disorders and the development of obesity [Abenavoli, L., 2019 г. Julita Tokarek, et, 2022]. The problem of the relationship of the composition, metabolic effects of intestinal microbiota in the development of obesity has not been sufficiently studied and requires additional clarification. The study included children aged 6-18 years with obesity or overweight (74 people) (SDS BMI criterion ≥ 1) and 44 conditionally healthy children and adolescents without acute and severe chronic diseases with normal body weight (SDS BMI ≤1.0, WHO criteria). Anamnestic data were analyzed with the identification of risk factors for the development of obesity and metabolic syndrome, objective status data were evaluated, venous blood was taken (general blood analysis, biochemical blood analysis, study of the extended lipid spectrum (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, atherogenicity index), hormones (insulin, leptin, resistin, irisin, GLP-1 and GLP-2). Instrumental research methods (ultrasound examination of abdominal organs, bioimpedance). Microbiota composition was studied by mass spectrometry (blood and feces) and 16S-RNA sequencing (feces) and microbiota metabolic activity by gas mass spectrometry (feces). The aim of the study was to establish the significance of the composition and metabolic activity of the intestinal microbiota, clinical and hormonal disorders in overweight and obese children and adolescents for early diagnosis of carbohydrate metabolism disorders. Data have been obtained that the taxonomic composition of the intestinal microbiota in obese and overweight children is characterized by the predominance of a stable phylum (type) of <em>Actinobacteriota</em> and a decrease in the phylum of <em>Bacteroidota</em>, which are part of the phylogenetic nucleus. The metabolic activity of the intestinal microbiota in obese and overweight children is characterized by a decrease in the production of all short-chain fatty acids, mainly butyrate, which is accompanied by a decrease in some types of butyrate-producing bacteria, such as <em>Faecalibacterium</em>. The greatest influence on metabolic activity is exerted by bacteria of the genus <em>Bacteroides</em>, the species <em>Bacteroides_eggerthii</em>. A decrease in the production of short-chain fatty acids in obese and overweight children leads to a decrease in the level of incretins, especially GLP-1 and GLP-2 in the blood, contributing to the development of carbohydrate metabolism disorders.</p>
Dihydrofolate reductase metabolic activity controls neurogenic transitions in the developing human and mouse neocortex [ChIP-seq]
GEO Series GSE206407. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Fatty acid-activated proton transporter SR4 prevents hepatic steatosis and metabolic alterations in diabetic mice by improving mitochondria function, energy balance and oxidative stress
GEO Series GSE308701. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Valine enhances intramuscular fat deposition through activating autophagy and fatty acid metabolism pathways in C2C12 myoblasts
GEO Series GSE217813. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.