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564
datasets available to search
ShareScore release 0.9.0
Dataset results
564 results for “smooth muscle cells”
Effect of TGF-B treatment on human vascular smooth muscle cells
GEO Series GSE30004. Homo sapiens. 24 samples. Type: Expression profiling by array.
HINT1 Aggravates Aortic Aneurysm by Targeting ITGA6/FAK Axis in Vascular Smooth Muscle Cells
GEO Series GSE289426. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A single-cell transcriptomic inventory of murine smooth muscle cells [lung]
GEO Series GSE210100. Mus musculus. 1376 samples. Type: Expression profiling by high throughput sequencing.
LncVSM (AK098656) down-regulation in Vascular Smooth Muscle cells
GEO Series GSE76720. Homo sapiens. 8 samples. Type: Expression profiling by array.
Single-Cell RNAseq Analysis of Murine Fate-Mapped Tsc1+/+ and Tsc1-/- Aortic Smooth Muscle Cells
GEO Series GSE135240. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide gene expression in Marfan Syndrome smooth muscle cells (MFS-SMCs) in comparison to that in mutation corrected (mcMFS-SMCs)
GEO Series GSE78833. Homo sapiens. 12 samples. Type: Expression profiling by array.
Isoliensinine promotes the clearance of senescent vascular smooth muscle cells by natural killer cells [MOVAS]
GEO Series GSE318401. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Senescent cells suppress innate vascular smooth muscle cell repair functions
GEO Series GSE130382. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Next generation sequencing facilliates quantitative analysis of Wild type and KitW/Wv Smooth muscle cells transcriptomes
GEO Series GSE168110. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA sequencing of medial vascular smooth muscle cells of normal aorta from healthy mouse
GEO Series GSE194173. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
microRNA expression analysis following 24h siRNA knockdown of transforming growth factor β receptor III (TGFBR3) in human pulmonary arterial smooth muscle cells.
GEO Series GSE92554. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by array.
Indazole-Cl inhibition of hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells
GEO Series GSE113940. Rattus norvegicus. 5 samples. Type: Expression profiling by high throughput sequencing.
Microarray expression profile and bioinformatics analysis of circular RNAs in the phenotypic switching of rat vascular smooth muscle cells: a preliminary study
GEO Series GSE190952. Rattus norvegicus. 6 samples. Type: Non-coding RNA profiling by array.
Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
GEO Series GSE228491. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Microarray-based gene expression of rabbit basilar artery smooth muscle cells exposed to hemodynamic insult
GEO Series GSE61212. Oryctolagus cuniculus. 6 samples. Type: Expression profiling by array.
Gene expression analysis following 24h- and 48h-siRNA knockdown of transforming growth factor β receptor III (TGFBR3) in human pulmonary arterial smooth muscle cells (hPASMC).
GEO Series GSE92481. Homo sapiens. 14 samples. Type: Expression profiling by array.
scRNA-seq of aortas from mice with Wnk1 deletion in vascular smooth muscle cells (experiment 2)
GEO Series GSE268125. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway "
<p>Link to dataset related to article "The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway"</p> <p>Abstract</p> <p><strong>Aims: </strong> Histone H3 dimethylation at lysine 79 is a key epigenetic mark uniquely induced by methyltransferase disruptor of telomeric silencing 1-like (DOT1L). We aimed to determine whether DOT1L modulates vascular smooth muscle cell (VSMC) phenotype and how it might affect atherosclerosis in vitro and in vivo, unravelling the related mechanism.</p> <p><strong>Methods and results: </strong> Gene expression screening of VSMCs stimulated with the BB isoform of platelet-derived growth factor led us to identify Dot1l as an early up-regulated epigenetic factor. Mouse and human atherosclerotic lesions were assessed for Dot1l expression, which resulted specifically localized in the VSMC compartment. The relevance of Dot1l to atherosclerosis pathogenesis was assessed through deletion of its gene in the VSMCs via an inducible, tissue-specific knock-out mouse model crossed with the ApoE-/- high-fat diet model of atherosclerosis. We found that the inactivation of Dot1l significantly reduced the progression of the disease. By combining RNA- and H3K79me2-chromatin immunoprecipitation-sequencing, we found that DOT1L and its induced H3K79me2 mark directly regulate the transcription of Nf-κB-1 and -2, master modulators of inflammation, which in turn induce the expression of CCL5 and CXCL10, cytokines fundamentally involved in atherosclerosis development. Finally, a correlation between coronary artery disease and genetic variations in the DOT1L gene was found because specific polymorphisms are associated with increased mRNA expression.</p> <p><strong>Conclusion: </strong> DOT1L plays a key role in the epigenetic control of VSMC gene expression, leading to atherosclerosis development. Results identify DOT1L as a potential therapeutic target for vascular diseases.</p>
Exploring Origin-dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases via Intersectional Genetics
GEO Series GSE278774. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
The spatiotemporal expression profile of ATF3 determines the fate of smooth muscle cells in abdominal aortic aneurysm development
GEO Series GSE261595. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.