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ShareScore release 0.7.1
Dataset results
548 results for “cardiac function”
Effectiveness of Tai Chi on Cardiac Autonomic Function and Symptomatology in Women With Fibromyalgia: a Randomized Controlled Trial
ClinicalTrials.gov study NCT03016585. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Frusemide Infusion for the Prevention of Deterioration in Renal Function Post Cardiac Surgery.
ClinicalTrials.gov study NCT00246675. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Postoperative Arrhythmia and Preoperative Cardiac Function
ClinicalTrials.gov study NCT06999681. IPD Sharing: NO. Countries: 0. Publications: 0.
RNA helicase DDX5 maintains cardiac function by regulating CamkIIδ alternative splicing [RIP-seq]
GEO Series GSE248444. Rattus norvegicus. 8 samples. Type: Other.
Multi-omics profiling visualizes dynamics of cardiac development and functions [ChIP-Seq]
GEO Series GSE213572. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A crucial function for c-Kit(+) in cardiac regeneration: role of Wnt inhibition
GEO Series GSE90615. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice (western blot, histology, and immunohistochemistry)
Purpose: Astronauts traveling beyond low Earth orbit will be exposed to high linear energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged particle irradiation. Materials and methods: Male C57BL/6 J mice were exposed to oxygen ions (16O, 600 MeV/n at 0.25 to 0.26 Gy/min to a total dose of 0, 0.05, 0.1, 0.25, or 1 Gy), protons (150 MeV, 0.35 to 0.55 Gy/min to 0, 0.5, or 1 Gy), or protons (150 MeV, 0.5 Gy) followed by 16O (600 MeV/n, 0.1 Gy). Separate groups of mice received 137Cs γ rays (1 Gy/min to 0, 0.5, 1, or 3 Gy) as a reference. Cardiac function and blood velocity were measured with ultrasonography at 3, 5, 7, and 9 months after irradiation. At 2 weeks, 3 months, and 9 months, cardiac tissue was collected to assess apoptosis, tissue remodeling, and markers of immune cells. Results: Ejection fraction and fractional shortening decreased at 3 and 7 months after 16O. These parameters did not change in mice exposed to γ rays, protons, or protons followed by 16O. Each of the radiation exposures caused only small increases in cleaved caspase3 and numbers of apoptotic nuclei. Changes in the levels of α smooth muscle cell actin and a 75kDa peptide of collagen type III in the left ventricle suggested tissue remodeling, but there was no significant change in total collagen deposition at 2 weeks, 3 months, and 9 months. Increases in protein amounts of cluster of differentiation (CD)2, CD68, and CD45 as measured with immunoblots at 2 weeks, 3 months, and 9 months after exposure to protons or 16O alone suggested immune cell infiltration. For type III collagen, CD2 and CD68, the efficacy in inducing protein abundance of CD2, CD68, and CD45 was 16O greater than protons was greater than γ rays greater than protons followed by 16O. Conclusions: Low dose, high energy charged particle irradiation caused mild changes in cardiac function and tissue remodeling in the mouse. This dataset derives result from the western blot, histology, and immunohistochemistry assays.
Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice (echocardiogram/ultrasonography)
Purpose: Astronauts traveling beyond low Earth orbit will be exposed to high linear energy transfer charged particles. Because there is concern about the adverse effects of space radiation on the cardiovascular system, this study assessed cardiac function and structure and immune cell infiltration in a mouse model of charged particle irradiation. Materials and methods: Male C57BL/6 J mice were exposed to oxygen ions (16O, 600 MeV/n at 0.25 to 0.26 Gy/min to a total dose of 0, 0.05, 0.1, 0.25, or 1 Gy), protons (150 MeV, 0.35 to 0.55 Gy/min to 0, 0.5, or 1 Gy), or protons (150 MeV, 0.5 Gy) followed by 16O (600 MeV/n, 0.1 Gy). Separate groups of mice received 137Cs γ rays (1 Gy/min to 0, 0.5, 1, or 3 Gy) as a reference. Cardiac function and blood velocity were measured with ultrasonography at 3, 5, 7, and 9 months after irradiation. At 2 weeks, 3 months, and 9 months, cardiac tissue was collected to assess apoptosis, tissue remodeling, and markers of immune cells. Results: Ejection fraction and fractional shortening decreased at 3 and 7 months after 16O. These parameters did not change in mice exposed to γ rays, protons, or protons followed by 16O. Each of the radiation exposures caused only small increases in cleaved caspase3 and numbers of apoptotic nuclei. Changes in the levels of α smooth muscle cell actin and a 75kDa peptide of collagen type III in the left ventricle suggested tissue remodeling, but there was no significant change in total collagen deposition at 2 weeks, 3 months, and 9 months. Increases in protein amounts of cluster of differentiation (CD)2, CD68, and CD45 as measured with immunoblots at 2 weeks, 3 months, and 9 months after exposure to protons or 16O alone suggested immune cell infiltration. For type III collagen, CD2 and CD68, the efficacy in inducing protein abundance of CD2, CD68, and CD45 was 16O greater than protons was greater than γ rays greater than protons followed by 16O. Conclusions: Low dose, high energy charged particle irradiation caused mild changes in cardiac function and tissue remodeling in the mouse. This dataset derives result from the cardiac ultrasound and abdominal aorta doppler (echocardiography) assays.
Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development
GEO Series GSE318090. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)
GEO Series GSE135404. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
CRISPR-Cas9 base editing to render CaMKIIδ phosphoresistant improves survival and cardiac function in heart failure
GEO Series GSE227720. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cardiac Transcriptome Dynamics and MEF2 Function in Response to Chronic β-Adrenergic Blockade During Heart Failure
GEO Series GSE75213. Rattus norvegicus; Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Functional dissection of human cardiac enhancers with hiPSC-CMs and lentiMPRA
GEO Series GSE211417. Homo sapiens. 24 samples. Type: Other.
DNA-damaging Chemotherapy altered the Cardiac Pathogenesis by reshaping the Composition and Functionality of Cardiac Resident Macrophages (bulk RNA-Seq).
GEO Series GSE275096. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing.
Gestational diabetes exposure induces an altered cardiac transcriptome that is associated with impaired cardiac function in the rat offspring
GEO Series GSE136737. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
Functional dissection of human cardiac enhancers and non-coding de novo variants in congenital heart disease
GEO Series GSE210376. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
Tiered Sympathetic Control of Cardiac Function Revealed by Viral Tracing and Single Cell Transcriptome Profiling
GEO Series GSE231924. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
RNAseq of hPSC-derived cardiac progenitors: normal vs. polyI:C treated (functionally advanced), and TGFbeta treated (cardiac fibroblast progenitors)
GEO Series GSE98941. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Potent Suppression of Heme-Induced Ferroptosis in Cardiomyocytes Enhances Cardiac Function Following Myocardial Infarction/Reperfusion Injury
GEO Series GSE285626. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Disruption of Ah Receptor Signaling during Mouse Development Leads to Abnormal Cardiac Structure and Function in the Adult
GEO Series GSE73787. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.