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8,060 results for “injury”
Gut microbiota-derived gamma-aminobutyric acid from metformin treatment reduces hepatic ischemia/reperfusion injury by inhibiting ferroptosis
<div>Hepatic ischemia/reperfusion injury (HIRI) is a common and inevitable factor leading to poor prognosis in various liver diseases, making the outcomes of current treatments in the clinic unsatisfactory. Metformin has been demonstrated to be beneficial in alleviating HIRI in recent studies, however, the underpinning mechanism remains unclear. In this study, we found metformin mitigates HIRI-induced ferroptosis through reshaped gut microbiota in mice, which was confirmed by the results of fecal microbiota transplantation treatment but showed the elimination of the beneficial effects when gut bacteria were depleted using antibiotics. Detailedly, through 16S rRNA and metagenomic sequencing, we identified that the metformin-reshaped microbiota was characterized by the increase of gamma-aminobutyric acid (GABA) producing bacteria. This increase was further confirmed by the elevation of GABA synthesis key enzymes, glutamic acid decarboxylase, and putrescine aminotransferase, in gut microbes of metformin-treated mice and healthy volunteers. Furthermore, the benefit of GABA against HIRI-induced ferroptosis was demonstrated in GABA-treated mice. Collectively, our data indicate that metformin can mitigate HIRI-induced ferroptosis by reshaping gut microbiota, with GABA identified as a key metabolite.</div>
Prospective case series of Standardbred racehorses treated with intra-lesional ultrasound-guided injection of platelet-rich plasma for suspensory ligament branch injuries
<p><strong>Abstract</strong> </p> <p>Standardbred racehorses are frequently diagnosed with suspensory ligament branch injuries which results in loss of earnings and morbidity. This prospective study aims to measure outcomes for suspensory ligament branch desmitis (SLBD) in Standardbred racehorses treated with intra-lesional platelet rich plasma (PRP).</p> <p> </p> <p>All Standardbred racehorses presented at the Vets On Wheels clinic in Marsa between 01.10.2019 and 31.12.2020 with grade 2-3 SLBD diagnosed ultrasonographically were included. All core lesions were injected with PRP under ultrasound guidance following standardised blood collection and centrifugal processes. All horses underwent a standardised rehabilitation protocol. Racing data including number of starts and earning following treatment was retrieved from the Malta Racing Club database.</p> <p> </p> <p>Twelve Standardbred racehorses were included in the study with a mean age of 9 years (range; 6 – 12). Forelimb lesions accounted for 36% of injuries. Seven horses (58%) returned to racing, although only two (17%) started more than two races. The average time elapsed between treatment and date of first start was 200 days.</p> <p> </p> <p>To the authors knowledge this is the first study to examine SLBD outcomes following PRP treatment in Standardbred racehorses. Older racing Standardbreds with grade 2/3 SLBD have a guarded prognosis for return to racing, as documented within racing Thoroughbred populations. Whether or not intra-lesional PRP alters the prognosis cannot be ascertained from this study.</p>
Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients
<p>Data set for article entitled: </p> <p><span>Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients</span></p>
A neurocognitive approach to prevent non-contact anterior cruciate ligament injury in football: A scoping review
<p><em>Background - </em>Non-contact anterior cruciate ligament injuries (NC-ACLI) are becoming more common in football due to the involvement of actions such as cutting, landing, pivoting, changing directions, and jumping that expose the knee to angular stresses, rotational motions, and anterior translation force. These risk factors are addressed in the current injury prevention programs(IPP) but have shown to be less effective in further lowering NC-ACLI risk. The missing piece in these IPPs is their inability to target neurocognitive risk factors when a relationship between cognitive competencies and the mechanism of NC-ACLI is evidenced. This gap serves as the basis for the review.</p> <p><em>Purpose – </em>To map the literature that has investigated the application of neurocognitive training (NCT) for the prevention of NC-ACLI in footballers.</p> <p><em>Study Design – </em>Scoping Review</p> <p><em>Methods – </em>A broad eligibility criteria was applied through population, concept, and context framework. Restrictions were applied to language (English) and age (>11 years), as the incidence rises with age. 39 databases and 4 websites were searched for literature until August 12, 2023. Four studies were included after screening the 144 studies found. Each study underwent quality assessment. The data was extracted and synthesised using data chart.</p> <p><em>Results – </em>The reviewed studies provided comprehensive details on components of NCT with methods and provider of intervention, outcome of NCT application and the cognitive skills targeted, along with the theoretical explanations for their outcomes. The limited number of included studies despite broad eligibility criteria, indicates the emerging nature of research in this domain, corroborated by recent publication dates of included literature.</p> <p><em>Conclusion – </em>This review provides baseline information on NCT in the prevention of NC-ACLI in football and attempts to guide future research.</p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate the motor disorder and brain pathological injury in mice with cerebral palsy
<p>Supplementary Table 1.The statistics of the pole-climbing experiments and the horizontal network test</p> <p>Supplementary Table 2.Results of Kruskal–Wallis test as presented in pole-climbing experiments and the horizontal network test.</p> <p>Supplementary Figure 1. Identification of human umbilical cord mesenchymal stem cell exosomes (hUC-MSCs-exos)</p> <p>Supplementary Figure 2. Results of horizontal network test and pole-climbing experiments.</p> <p> </p>
Human umbilical cord mesenchymal stem cell-derived exosomes combined with mouse nerve growth factor can more effectively ameliorate themotor disorder and brain pathological injury inmice with cerebral palsy
<p>This research design.</p>
The comparison of marine collagen peptides and soy peptide supplementation on skeletal muscular Calpain-1/2 mRNA expressions and micro-injury in rats
<p>Dataset of a research article named 'The comparison of marine collagen peptides and soy peptide supplementation on skeletal muscular Calpain-1/2 mRNA expressions and micro-injury in rats'.</p>
Data from: Age-at-injury influences the glial response to traumatic brain injury in the cortex of male juvenile rats
<p>Glia influence neuronal development and aging. Few translational studies have examined how age at injury affects the glial response to traumatic brain injury (TBI). We hypothesized that rats injured before sexual maturity would exhibit a greater glial response, that persists into early adulthood, compared to rats injured near the onset of sexual maturity.</p> <p>Postnatal day (PND)17 and PND35 rats received midline fluid percussion injury or sham surgery. In three cortical regions (peri-injury, S1BF, perirhinal), we investigated the glial response relative to age at injury, time post-injury (2H, 1D 7D, 25D, and 43D), and post-natal age, such that rats injured at PND17 or PND35 were compared at the same post-natal-age (e.g., PND17+25d post-injury=PND42; PND35+7d post-injury=PND42). We measured Iba1+ microglia cells and quantified their activation status. GFAP expression was examined using immunohistochemistry. Data were analyzed using Bayesian multivariate multi-level models.</p> <p>Independent of age at injury, TBI activated microglia (shorter branches, fewer endpoints) in the cortex with more microglia in all regions compared to shams. TBI-induced microglial activation was sustained in the S1BF into early adulthood (PND60). PND17 injured rats had more microglial activation in the perirhinal cortex than PND35 injured rats. Activation was not confounded by age-dependent cell size changes, and microglial cell body sizes were similar between ages.</p> <p>Increased microglial activation in PND17 injured rats suggests that TBI upregulates the glial response at discrete stages of development. Age at injury and aging with an injury are translationally important because experiencing a TBI during early childhood may trigger an exaggerated glial response.</p>
Treatment with 3-aminobenzamide during ex vivo lung perfusion of damaged rat lungs reduces graft injury and dysfunction after transplantation
<p>Ex vivo lung perfusion (EVLP) with pharmacological reconditioning may increase donor lung utilization for transplantation (LTx). 3-Aminobenzamide (3-AB), an inhibitor of poly (ADP-ribose) polymerase (PARP), reduces ex vivo lung injury in rat lungs damaged by warm ischemia (WI). Here we determined the effects of 3-AB reconditioning on graft outcome after LTx. Three groups of donor lungs were studied: Control (Ctrl): 1 hour WI + 3 hours cold ischemia (CI) + LTx; EVLP: 1 hour WI + 3 hours EVLP + LTx; EVLP + 3-AB: 1 hour WI + 3 hours EVLP + 3-AB (1 mg<sup>.</sup>mL<sup>−1</sup>) + LTx. Two hours after LTx, we determined lung graft compliance, edema, histology, neutrophil counts in bronchoalveolar lavage (BAL), mRNA levels of adhesion molecules within the graft, as well as concentrations of interleukin-6 and 10 (IL-6, IL-10) in BAL and plasma. 3-AB reconditioning during EVLP improved compliance and reduced lung edema, neutrophil infiltration, and the expression of adhesion molecules within the transplanted lungs. 3-AB also attenuated the IL-6/IL-10 ratio in BAL and plasma, supporting an improved balance between pro- and anti-inflammatory mediators. Thus, 3-AB reconditioning during EVLP of rat lung grafts damaged by WI markedly reduces inflammation, edema, and physiological deterioration after LTx, supporting the use of PARP inhibitors for the rehabilitation of damaged lungs during EVLP.</p>
supplementary file_Differences_in_Sports_Injury_Types_According_to_Taekwondo_Athlete_Types
<p>Supplementary_files(data table); Informed consent form for reseach project_legal agent; Certificate_of_editing</p>
Code for: Comparison and interpretability of machine learning models to predict severity of chest injury
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective:</b> Trauma quality improvement programs and registries improve care and outcomes for injured patients. Designated trauma centers calculate injury scores using dedicated trauma registrars; however, many injuries arrive at non-trauma centers, leaving a substantial amount of data uncaptured. We propose automated methods to identify severe chest injury using machine learning (ML) and natural language processing (NLP) methods from the electronic health record (EHR) for quality reporting.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Materials and Methods:</b> A level I trauma center was queried for patients presenting after injury between 2014 and 2018. Prediction modeling was performed to classify severe chest injury using a reference dataset labeled by certified registrars. Clinical documents from trauma encounters were processed into concept unique identifiers for inputs to ML models: logistic regression with elastic net regularization (EN), extreme gradient boosted machines (XGB), and convolutional neural networks (CNN). The optimal model was identified by examining predictive and face validity metrics using global explanations.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Results:</b> Of 8,952 encounters, 542 (6.1%) had a severe chest injury. CNN and EN had the highest discrimination, with an area under the receiver operating characteristic curve of 0.93 and calibration slopes between 0.88 and 0.97. CNN had better performance across risk thresholds with fewer discordant cases. Examination of global explanations demonstrated the CNN model had better face validity, with top features including "contusion of lung" and "hemopneumothorax." </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Discussion: </b>The CNN model featured optimal discrimination, calibration, and clinically relevant features selected. </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Conclusion:</b> NLP and ML methods to populate trauma registries for quality analyses are feasible.</span></span></span></span></span></span></span></span></span></span></span></p>
Data for Aloe vera for Ischemic-Reperfusion Injury after Tourniquet Application
<p>Raw data for Aloe vera for Ischemic-Reperfusion Injury after Tourniquet Application</p> <p>Arrive checklist for Aloe vera for Ischemic-Reperfusion Injury after Tourniquet Application</p>
"Early COVID-related Acute Kidney Injury Recovery May Course with Hydroelectrolytic Disorders in Patients With High Risk of Insensible Fluid Loss" dataset
<p>The dataset used and analyzed during the study "<strong>Early COVID-related Acute Kidney Injury Recovery May Course with Hydroelectrolytic Disorders in Patients With High Risk of Insensible Fluid Loss"</strong></p>
Fibroblast Growth Factor receptor signaling in cardiomyocytes is protective in the acute phase following ischemia-reperfusion injury
<p>Suplemental echocardiographic images</p>
Urinary Sodium Excretion is Low Prior to Acute Kidney Injury in Intensive Care Unit Patients
<p>Dataset corresponding to the submitted manuscript "Urinary Sodium Excretion is Low Prior to Acute Kidney Injury in Intensive Care Unit Patients"</p> <p>doi: 10.3389/fneph.2022.929743</p>
Data from: A short peptide exerts neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKKβ/NF-κB axis
<p><strong><span>Background</span></strong></p> <p><span>Despite considerable efforts, ischemic stroke (IS) remains a challenging clinical problem. Therefore, the discovery of effective therapeutic and targeted drugs based on the underlying molecular mechanism is crucial for effective IS treatment.</span></p> <p><strong><span>Methods</span></strong></p> <p><span>A cDNA-encoding peptide was extracted and identified from RNA extracted from <em>Rana limnocharis</em> skin, and its neuroprotective properties were evaluated using a middle cerebral artery occlusion/reperfusion (MCAO/R) model in rats and an oxygen-glucose deprivation/reperfusion (OGD/R) model in neuron-like PC12 cells. The underlying molecular mechanisms were explored using microRNA (miRNA) sequencing, quantitative real-time polymerase chain reaction</span><span>, dual-luciferase reporter gene assay, and western blotting.</span></p> <p><strong><span>Results</span></strong></p> <p><span>A new peptide (NP1) with an amino acid sequence of '</span><span>FLPAAICLVIKTC</span><span>' was identified. NP1 showed no obvious toxicities <em>in vivo</em> and <em>in vitro</em>. I</span><span>ntraperitoneal administration of NP1 (10 nmol/kg) effectively reduced the volume of cerebral infarction and relieved neurological dysfunction in MCAO/R model rats. Moreover, NP1 significantly alleviated the decrease in viability of PC12 cells induced by OGD/R. NP1 effectively suppressed inflammation by reducing interleukin-1β (</span><span>IL-1β) and </span><span>tumor necrosis factor-</span><span>α (</span><span>TNF-α) levels </span><em><span>in vitro</span></em><span> and <em>in vivo</em>. Furthermore, NP1 up-regulated the expression of miRNA-6328, which targeted down-regulation of the inflammation-related factor inhibitor kappa B kinase β (</span><span>IKKβ),</span><span> thereby reducing nuclear factor-kappa B p65</span><span> (NF-κB</span><span> p65) and inhibitor of </span><span>NF-κB</span><span> (I-</span><span>κ</span><span>B) phosphorylation and inhibiting the </span><span>NF-κB</span><span> pathway.</span></p> <p><strong><span>Conclusions</span></strong></p> <p><span>NP1 exerted neuroprotective effects by reducing inflammation via the miRNA-6328/IKKβ/NF-κB axis. This study highlights the importance of peptides in the development of new drugs, elucidation of </span><span>pathological mechanisms, and discovery of new drug targets.</span></p>
Lipidomic profiling indicate protection of hypoxic-ischemic brain injury on neonatal rats ingesting Acer truncatum Bunge oil
<p>Hypoxic ischemic encephalopathy (HIE) has a serious effect on newborn growth and development, and there are currently no effective interventions. In this study, we discovered administering <em>Acer truncatum Bunge seed </em>oil (ASO) for 30 days reduces the damage caused by HIE and improves the learning and memory ability. Using lipidomics approaches to compare metabolite changes in HIE and sham rats, we discovered that glycerophospholipids, plasmalogen, unsaturated fatty acids decreased and lysophospholipids increased in HIE rats' brain. After 30 days of ASO treatment, glycerophospholipids, plasmalogen, and unsaturated fatty acids increased in serum and brain, while lysophospholipids and oxidized glycerophospholipids decreased. Based on cluster, correlation and attribution analysis, we find changes of glycerophospholipids, plasmalogen, w3/6/9 fatty acid, oxidized GP and lysophospholipids contributes to improvement of cognitive ability, indicated by eliminating the oxidative injury by HIE. Our findings suggest that ASO may be a potential special medical food for ischemic hypoxic newborns.</p>
Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients
<p>Dataset for article entitled: </p> <p><span>Effectiveness of Mannitol Use on Clinical Outcomes of Severe Traumatic Brain Injury Patients</span></p>
Data from: Icing-related injuries in polar bears (Ursus maritimus) at high latitudes
<p>Climate change has broad ecological implications for wildlife, especially for species that rely on temperature-sensitive habitats. For polar bears (<em>Ursus maritimus</em>), loss of Arctic sea ice reduces access to prey and lengthens seasonal fasting periods leading to behavioral, nutritional, and reproductive impacts that may result in population declines. Secondary factors, such as disease and contaminants can exacerbate primary stressors and new health-related conditions are likely to emerge. For example, once unusual but now increasingly frequent warming cycles are creating unprecedented icing conditions that have demographic consequences for cold-adapted mammals.</p> <p>We report on icing-related lesions observed in wild polar bears during live-capture research in two high-latitude subpopulations, Kane Basin (KB) and East Greenland (EG), between 2012 and 2022. We observed ice build-up, hair loss (alopecia), and skin ulcerations primarily affecting the feet of adult bears as well as other parts of the body. The most severely affected individuals had blocks of ice up to 30 cm in diameter adhered to the foot pads, deep, bleeding ulcerations of foot pads and exhibited lameness. These injuries have not been observed during previous research in these areas or reported in the scientific literature, suggesting this may be a new phenomenon. To provide context for our observations, we conducted interviews with Indigenous polar bear subsistence hunters in West and East Greenland and Nunavut to document Indigenous knowledge about the potential causes and frequency of these injuries.</p>
Seurat objects for "Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state" (https://doi.org/10.1038/s41467-023-42762-w)
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