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602
datasets available to search
ShareScore release 0.9.0
Dataset results
602 results for “natural killer cell”
Natural killer cells regulate pulmonary macrophages polarization in host defense chlamydial lung infection
GEO Series GSE183577. synthetic construct; Mus musculus. 6 samples. Type: Non-coding RNA profiling by array.
Enhancement of the anticancer ability of natural killer cells through allogeneic mitochondrial transfer
GEO Series GSE224187. Homo sapiens. 6 samples. Type: Expression profiling by array.
Selective modulation of inflammatory Natural Killer (NK) cell phenotypes following histone H3K27 demethylase inhibition [ATAC-Seq and ChIP-Seq]
GEO Series GSE89668. Homo sapiens. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Gene expression profile of canine Chimeric Antigen Receptor (CAR) Engineered invariant Natural Killer T (iNKT) cells
GEO Series GSE229458. Canis lupus familiaris. 6 samples. Type: Expression profiling by array.
Molecular signatures in natural-killer (NK) cell lymphoma
GEO Series GSE19067. Homo sapiens. 44 samples. Type: Expression profiling by array.
CALHM6 is an immunological synapse ion channel required for macrophage-natural killer cell communication upon bacterial infection
GEO Series GSE223008. Mus musculus. 41 samples. Type: Expression profiling by high throughput sequencing.
Natural killer cells are required for the recruitment of CD8+ T cells and the efficacy of immune checkpoint blockade in melanoma brain metastases
GEO Series GSE264376. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Harnessing STING Signaling and Natural Killer Cells to overcome PARP Inhibitor Resistance in Homologous Recombination Repair altered Breast Cancer [RNA-seq]
GEO Series GSE290828. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Natural killer cells suppress T cell tumor immune evasion
GEO Series GSE134265. Mus musculus. 35 samples. Type: Expression profiling by high throughput sequencing; Other.
Experimental Malaria Infection Triggers Early Expansion of Natural Killer Cells - NK cell response
GEO Series GSE12727. Mus musculus. 10 samples. Type: Expression profiling by array.
In vivo G-CSF Treatment Activates GR-SOCS1 Axis Suppressing IFN-γ Secretion by Natural Killer Cells [CUT&TAG]
GEO Series GSE205824. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expression profiling of Natural killer B cells
GEO Series GSE80063. Mus musculus. 3 samples. Type: Expression profiling by array.
Multi-omics: In vivo G-CSF Treatment Activates GR-SOCS1 Axis Suppressing IFN-γ Secretion by Natural Killer Cells
GEO Series GSE205825. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics [ChIP-seq]
GEO Series GSE197572. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression of Natural Killer cell-primed monocytes and their subsequent derived dendritic cells
GEO Series GSE116487. Homo sapiens. 30 samples. Type: Expression profiling by array.
The transcription program of Runx3 in natural killer cells and CD8+ T cells
GEO Series GSE50131. Mus musculus. 48 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Targeting SUMOylation triggers interferon-beta-dependent activation of patient and allogenic Natural Killer cells in preclinical models of Acute Myeloid Leukemia [ATAC-seq I]
GEO Series GSE263923. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Selective modulation of inflammatory Natural Killer (NK) cell phenotypes following histone H3K27 demethylase inhibition
GEO Series GSE89669. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
ATAC-seq and RNA-seq of hematopoietic progenitor cells (HPC) and Natural Killer (NK) cells transduced with transcription factors T-BET or EOMES
GEO Series GSE166439. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Diabetic peripheral neuropathy is associated with changes in the frequency and function of circulating Natural Killer cells: results of a pilot study in patients with diabetic foot.
<p><strong><span>Background: </span></strong><span>Diabetic critical limb-threatening ischemia (CLTI) is a severe vascular disease with a high incidence of amputation and death. Circulating inflammatory markers may represent early diagnostic and prognostic tools. We previously showed that patients with diabetes mellitus and CLTI bear low abundance and impaired functionality of pro-angiogenic CD34<sup>+</sup> hematopoietic stem and progenitor cells (HSPCs) and high frequency of natural killer cells (NKs). However, no study assessed the frequency, phenotype, and function of NKs in the early stage of CLTI characterized by neuropathy.<strong> Methods: </strong>We enrolled 177 subjects sorted into 5 groups reflecting CLTI progression: 1) non-diabetic healthy controls (n=25), diabetic patients 2) without neurovascular complications (n=27), 3) with peripheral neuropathy (n=39), 4) with peripheral neuropathy and foot lesions (n=42), 5) with peripheral neuroischemia and foot lesions (n=44). We assessed the frequency of circulating B-, CD4<sup>+,</sup> and CD8<sup>+</sup> T-cells, NKs, and CD34<sup>+</sup>HSPCs, by a flow cytometry (FC)-based diagnostic kit. We investigated by FC the frequency of circulating NK subpopulations in donors with diabetic neuropathy (n=16) and controls (n=16). We characterized FACS-sorted circulating NKs secretome by antibody membrane arrays and we tested its pro-angiogenic potential<em> in vitro</em> and <em>in vivo</em> in <em>Hirudo verbana</em>.<strong> Results: </strong>Using age and sex-adjusted logistic multivariate models, we observed a decrease in CD34<sup>+</sup>HSPCs in all diabetic groups compared to control. Interestingly, NK frequency was increased in diabetic patients with neuropathy. Although the frequency of angiogenic NKs was similar in all groups, functionally, NKs from patients with diabetic neuropathy showed impaired degranulation <em>in vitro</em>, and reduced angiogenic ability <em>in vitro </em>and <em>in vivo</em>. Neuropathic NKs showed downregulation of angiogenic factors (IL-8, PDGF-B) and upregulation of factors related to monocyte/macrophage migration, effectively recruiting macrophages <em>in vivo</em>.<strong> Conclusion:</strong> By a routine laboratory test, we identified a specific cellular signature for patients with diabetes mellitus and peripheral neuropathy that includes low CD34<sup>+</sup>HSPCs and high NK frequency. Moreover, we show for the first time a functional impairment of NKs in neuropathic patients. If confirmed in larger cohorts, FACS detection of the circulating anti-angiogenic NK cell populations could be used for the early diagnosis of diabetic CLTI, a still unmet clinical need.</span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.