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543
datasets available to search
ShareScore release 0.9.0
Dataset results
543 results for “roles and responsibilities”
Integration of metabolomics and transcriptomic expression profiling discloses pivotal role of arachidonic acid metabolism pathway in response to acute hypoxia exposure
GEO Series GSE103940. Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Role of microRNAs in regulating the DNA damage response to ionizing radiation in Caenorhabditis elegans
GEO Series GSE124606. Caenorhabditis elegans. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Batf3-Dependent Orchestration of the Robust Th1 Responses and Fungal Control during Cryptococcal Infection, the role of cDC1.
GEO Series GSE253846. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Exploring the role of potato Pti5 in hypersensitive response-conferred resistance to Potato virus Y using short hairpin RNA-mediated gene silencing
GEO Series GSE136877. Solanum tuberosum. 12 samples. Type: Expression profiling by high throughput sequencing.
Altered microRNAs expression and gene expression in allicin-treated ileal tissues revealed their potential roles in regulating host responses to antimicrobials
GEO Series GSE74503. Bos taurus. 90 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Identification of the PhoB regulon and role of PhoU in the phosphate-starvation response of Caulobacter crescentus (expression)
GEO Series GSE71857. Caulobacter vibrioides NA1000. 10 samples. Type: Expression profiling by array.
Role of BHLHE40 in shaping macrophage inflammatory response
GEO Series GSE176174. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Refinement of BMYB function in response to androgenic stimulation reveals genomic and non-genomic roles involving possible fluid-phase transitions
GEO Series GSE124957. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Role of Macrophages in the Foreign Body Response to Poly(ethylene glycol) Hydrogels
GEO Series GSE185761. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
CCSER1 transcriptomic analysis reveals a role in neurodevelopmental phenotypes and alcohol response.
GEO Series GSE282155. Danio rerio. 29 samples. Type: Expression profiling by high throughput sequencing.
Dual role of the unfolded protein response in the therapeutic effect of AZD1775 on TP53 mutant high grade serous ovarian cancer
GEO Series GSE166417. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Identification of the PhoB regulon and role of PhoU in the phosphate-starvation response of Caulobacter crescentus
GEO Series GSE71961. Caulobacter vibrioides NA1000. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array.
Potential role of miRNA in acute hypoxic response of largemouth bass (Micropterus salmoides)
GEO Series GSE143641. Micropterus salmoides. 45 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Dataset related to article "Predictive and Prognostic Role of Metabolic Response in Patients With Stage III NSCLC Treated With Neoadjuvant Chemotherapy."
<p>INTRODUCTION:</p> <p>The purpose of this study was to assess the predictive and prognostic role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in candidates with stage III non-small-cell lung cancer (NSCLC) to neoadjuvant chemotherapy.</p> <p>PATIENTS AND METHODS:</p> <p>Sixty-six patients with stage III NSCLC treated with induction chemotherapy from March 2013 to December 2017 were retrospectively identified. Response assessment were evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and European Organisation for Research and Treatment of Cancer (EORTC) criteria. 18F-FDG PET/CT metabolic parameters were analyzed as absolute values as well as percentage changes (Δ) between 2 consecutive scans, for primary tumor (T) and for regional lymph nodes (N). All clinical variables and metabolic parameters were compared with treatment response and correlated with progression-free survival (PFS) and overall survival (OS), based on a median follow-up of 9.4 months.</p> <p>RESULTS:</p> <p>Post-induction therapy standardized uptake value (SUV)max_T, SUVmean_T, metabolic tumor volume (MTV_T), and total lesion glycolysis of the tumor (TLG_T) varied significantly between responders and non-responders (6.6 vs. 13.8; P = .001; 4.2 vs. 8.1; P < .001; 6 vs. 17.9; P = .002; and 24.1 vs. 136.3; P < .001, respectively). Likewise, percentage changes (Δ_T) were significantly different between the 2 groups (P < .001). Along with primary tumor, also post-SUVmax_N, post-SUVmean_N, and post-TLG_N (P = .024, P = .015, and P = .024, respectively), as well as all percentage changes (Δ_N) were different between responders and non-responders. RECIST 1.1 and EORTC response classifications were discordant in 27 patients (40.9%; κ = 0.265; P = .003). On multivariate analysis, post-TLG_N was an independent predictor for both PFS and OS, whereas RECIST 1.1 was a predictor only for OS.</p> <p>CONCLUSIONS:</p> <p>Several metabolic parameters may differentiate responders from non-responders following neoadjuvant chemotherapy in stage III NSCLC. As compared with RECIST 1.1, EORTC seems to be more appropriate for evaluation therapeutic response. Finally, post-TLG_N has significant prognostic information.</p>
Dataset related to article " PTX3 Regulation of Inflammation, Hemostatic Response, Tissue Repair, and Resolution of Fibrosis Favors a Role in Limiting Idiopathic Pulmonary Fibrosis."
<p>This record contains data related to article "PTX3 Regulation of Inflammation, Hemostatic Response, Tissue Repair, and Resolution of Fibrosis Favors a Role in Limiting Idiopathic Pulmonary Fibrosis."</p> <p>PTX3 is a soluble pattern recognition molecule (PRM) belonging to the humoral innate immune system, rapidly produced at inflammatory sites by phagocytes and stromal cells in response to infection or tissue injury. PTX3 interacts with microbial moieties and selected pathogens, with molecules of the complement and hemostatic systems, and with extracellular matrix (ECM) components. In wound sites, PTX3 interacts with fibrin and plasminogen and favors a timely removal of fibrin-rich ECM for an efficient tissue repair. Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive interstitial lung disease of unknown origin, associated with excessive ECM deposition affecting tissue architecture, with irreversible loss of lung function and impact on the patient's life quality. Maccarinelli et al. recently demonstrated a protective role of PTX3 using the bleomycin (BLM)-induced experimental model of lung fibrosis, in line with the reported role of PTX3 in tissue repair. However, the mechanisms and therapeutic potential of PTX3 in IPF remained to be investigated. Herein, we provide new insights on the possible role of PTX3 in the development of IPF and BLM-induced lung fibrosis. In mice, PTX3-deficiency was associated with worsening of the disease and with impaired fibrin removal and subsequently increased collagen deposition. In IPF patients, microarray data indicated a down-regulation of PTX3 expression, thus suggesting a potential rational underlying the development of disease. Therefore, we provide new insights for considering PTX3 as a possible target molecule underlying therapeutic intervention in IPF.</p>
A systems immunology approach reveals distinct roles of genetic and non-genetic factors in shaping variation of immune responses in cattle
<p>The VCF file contains 11486822 SNPs from 246 Belgian blue bulls utilized in a genome-wide association study focusing on immunophenotypes.</p>
Ecophysiological and molecular basis of drought responses in forest trees: the modulating role of canopy structure and light environment
GEO Series GSE208073. Abies pinsapo. 12 samples. Type: Expression profiling by high throughput sequencing.
The role of MiRNAs in the golden pompano’s (Trachinotus blochii) response to different reoxygenation rates after hypoxic stress
GEO Series GSE222797. Trachinotus blochii. 22 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Role of REDD1 in mouse skin response to proinflammatory 12-(O)-tetra-decanoyl-acetate (TPA) and anti-inflammatory glucocorticoid fluocinolone acetonide (FA)
GEO Series GSE183091. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Age Dependent Decrease in Vascular Remodeling Response in LDLr-/- mice unveils a role of Quaking in Vascular Homeostasis
GEO Series GSE9310. Mus musculus. 8 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.