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649 results for “brain gene expression”
Gene expression profiling for spaceflight induced-neuroinflammation in the mouse brain
The health risk from spaceflight-induced neuronal damage and potential adverse neurovascular effects is a chief concern. More recently, it has been proposed that neuroinflammatory response plays an important role in the neurovascular remodeling in the brain after stress. The goal of the present study was to characterize changes in the gene expression of neuroinflammation panel for inflammation, neuronal function, metabolism and stress in mouse brain tissue. Ten-week old male C57BL/6 mice were launched to the International Space Station (ISS) on Space-X 12 for a 35-day mission. Within 38+4 hours of splashdown, mice were returned to Earth alive. Brain tissues were collected for analysis. Habitat ground control (GC) mice were maintained on Earth in flight hardware cages. A novel digital color-coded barcode counting technology (NanoStringTM) was used to evaluate gene expression profiles in the spaceflight mouse brain. The Neuroinflammation panel includes 757 genes covering the core pathways and processes that define neuroimmune interactions. A set of 54 differently expressed genes (p less than 0.05) significantly segregates the GC group from flight (FLT) group. Many pathways associated with cellular stress, inflammation, apoptosis, and metabolism were significantly altered by flight conditions. Genes supporting neuronal synaptic signaling and migration were significantly downregulated in FLT compared to the GC mice. A decrease in the expression of genes important for oligodendrocyte differentiation and myelin sheath maintenance was observed. Moreover, mRNA expression of many genes related to antiviral signaling, reactive oxygen species (ROS) generation, and bacterial immune response were significantly downregulated. These data indicate that neuroinflammation and altered immune reactions may be closely associate with spaceflight-induced stress response and have an impact on the neuronal function that may result in chronic neuroinflammation and late neurodegeneration. A total of 12 frozen right caudal half hemispheres containing mid- and hindbrain from GC and FLT mice (n equals 6 per group), were used for analysis
Spaceflight-Induced Gene Expression Profiles in the Mouse Brain Are Attenuated by Treatment with the Antioxidant BuOE - Dentate Gyrus
The demands of deep space pose a health risk to the central nervous system that has long been a concern when sending humans to space. While little is known about how spaceflight affects transcription spatially in the brain, a greater understanding of this process has the potential to aid strategies that mitigate the effects of spaceflight on the brain. Therefore, we performed GeoMx Digital Spatial Profiling of mouse brains subjected to either spaceflight or grounded controls. Four brain regions were selected: Cortex, Frontal Cortex, Corunu Ammonis I, and Dentate Gyrus. Antioxidants have emerged as a potential means of attenuating the effects of spaceflight, so we treated a subset of the mice with a superoxide dismutase mimic, MnTnBuOE-2-PyP 5+ (BuOE). Our analysis revealed hundreds of differentially expressed genes due to spaceflight in each of the four brain regions. Both common and region-specific transcriptomic responses were observed. Metabolic pathways and pathways sensitive to oxidative stress were enriched in the four brain regions due to spaceflight. These findings enhance our understanding of brain regional variation in susceptibility to spaceflight conditions. BuOE reduced the transcriptomic effects of spaceflight at a large number of genes, suggesting that this compound may attenuate oxidative stress-induced brain damage caused by the spaceflight environment. This study contains data of dentate gyrus region. The data of other brain regions are deposited in OSD-682 (cornu ammonis 1), OSD-698 (frontal cortex), and OSD-699 (cerebral cortex).
Effect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes associated with microgravity and fluid shift a large-scale analysis of mRNA expression levels was performed in the brains of 2 weeks control and hindlimb-unloaded (HU) mice using cDNA microarrays. Although to different extent all functional categories displayed significantly regulated genes indicating that considerable transcriptomic alterations are induced by HU. Interestingly the TIC class (transport of small molecules and ions into the cells) had the highest percentage of up-regulated genes while the most down-regulated genes were those of the JAE class (Cell junction Adhesion Extracellular Matrix). TIC genes comprised 16% of those whose expression was altered including sodium channel nonvoltage-gated 1 beta (Scnn1b) glutamate receptor (Grin1) voltage-dependent anion channel 1 (Vdac1) calcium channel beta 3 subunit (Cacnb3) and others. The analysis performed by GeneMAPP revealed several altered protein classes and functional pathways such as blood coagulation and immune response learning and memory ion channels and cell junction. In particular data indicate that HU causes an alteration in hemostasis which resolves in a shift toward a more hyper-coagulative state with an increased risk of venous thrombosis. Furthermore HU treatment seems to impact on key steps of synaptic plasticity and learning processes. We used brains of four control (C1 C2 C3 C4) and four tail-suspended hindlimb-unloaded (E1 E2 E3 E4) mice to ensure statistical relevance of the study. 60 ug of total RNA extracted in TRIzol from each brain was reversed transcribed into labeled cDNAs using fluorescent Cy5 or Cy3-dUTP (Amersham Biosciences NJ). Differently labeled cDNAs obtained from a pair of biological replicas were co-hybridized overnight at 50C with a microscope slide spotted with ~ 27,000 mouse cDNA sequences produced by the Microarray Core Facility of the Albert Einstein College of Medicine in the xef xbf xbdmultiple yellow xef xbf xbd design (i.e.: C1C2 C3C4 E1E2 E3E4) described in Iacobas DA Fan C Iacobas S et al. Transcriptomic changes in developing kidney exposed to chronic hypoxia. Biochem Biophys Res Commun. 2006 349(1):329-38).
5-hydroxymethylcytosine is linked with expression of brain-specific protein-coding genes but not brain-specific microRNA host genes (RNA-Seq)
GEO Series GSE35235. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Gene co-expression networks in human brain predict chromatin modifications in alcohol abusers
GEO Series GSE29555. Homo sapiens. 128 samples. Type: Expression profiling by array.
Single-cell RNA sequencing analysis of the effect of 4-octyl itaconate administration on gene expression in immune cells isolated from traumatic brain injury mice brain
GEO Series GSE272808. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of cells from the dura mater and brain of mice subjected middle cerebral artery occlusion (MCAO) or Sham treatment.
GEO Series GSE229619. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Time-dependent gene expression patterns in injured brains of WT and LRRK2 G2019S mice.
GEO Series GSE215277. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Haldane’s rule in the developing brain: X-linked and imprinted genes contribute to male-biased transgressive expression in hybrid mice
GEO Series GSE311072. Mus spretus; Mus musculus domesticus x Mus spretus; Mus musculus domesticus. 89 samples. Type: Expression profiling by high throughput sequencing.
Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing
GEO Series GSE168599. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
differentially expressed genes in NDV infected chicken brains
GEO Series GSE121368. Gallus gallus. 3 samples. Type: Expression profiling by array.
Chronic hypercapnia-induced gene expression profiles in the brain
GEO Series GSE231308. Capra hircus. 72 samples. Type: Expression profiling by high throughput sequencing.
Gene expression file at single cell level of nerve cells in damaged areas of the cerebral cortex in mice with traumatic brain injury
GEO Series GSE276065. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Spatio-molecular gene expression reflects dorsal anterior cingulate cortex structure and function in the human brain [spatial transcriptomics]
GEO Series GSE296789. Homo sapiens. 21 samples. Type: Other.
Effect of STIM1 Knockout on gene expression in the Drosophila larval brain
GEO Series GSE202098. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in mice brain after ciguatoxin exposure
GEO Series GSE20949. Mus musculus. 9 samples. Type: Expression profiling by array.
Impact of Ketogenic diet on aging associated gene expression in the brain.
GEO Series GSE230324. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
A chronological expression profile of gene activity during embryonic mouse brain development
GEO Series GSE44932. Mus musculus. 24 samples. Type: Expression profiling by array.
Lead (Pb+2) effects in global gene expression in the larval brain of Drosophila melanogaster
GEO Series GSE77417. Drosophila melanogaster. 4 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of human brain metastasis samples
GEO Series GSE254379. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.