Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
568
datasets available to search
ShareScore release 0.9.0
Dataset results
568 results for “Glucose metabolism”
PXR-dependant dysregulation of glucose metabolism induced by chronic exposure to NOAEL-level pesticide mixture in mice
GEO Series GSE297527. Mus musculus. 15 samples. Type: Expression profiling by array.
Dataset related to article "Metabolome of Pancreatic Juice Delineates Distinct Clinical Profiles of Pancreatic Cancer and Reveals a Link between Glucose Metabolism and PD-1+ Cells"
<p>This record contains data related to the article "Metabolome of Pancreatic Juice Delineates Distinct Clinical Profiles of Pancreatic Cancer and Reveals a Link between Glucose Metabolism and PD-1+ Cells".</p> <p>Better understanding of pancreatic diseases, including pancreatic ductal adenocarcinoma (PDAC), is an urgent medical need, with little advances in preoperative differential diagnosis, preventing rational selection of therapeutic strategies. The clinical management of pancreatic cancer patients would benefit from the identification of variables distinctively associated with the multiplicity of pancre- atic disorders. We investigated, by 1H nuclear magnetic resonance, the metabolomic fingerprint of pancreatic juice (the biofluid that collects pancreatic products) in 40 patients with different pancreatic diseases. Metabolic variables discriminated PDAC from other less aggressive pancreatic diseases and identified metabolic clusters of patients with distinct clinical behaviors. PDAC specimens were overtly glycolytic, with significant accumulation of lactate, which was probed as a disease-specific variable in pancreatic juice from a larger cohort of 106 patients. In human PDAC sections, high expression of the glucose transporter GLUT-1 correlated with tumor grade and a higher density of PD-1+ T cells, suggesting their accumulation in glycolytic tumors. In a preclinical model, PD-1+ CD8 tumor–infiltrating lymphocytes differentially infiltrat- ed PDAC tumors obtained from cell lines with different metabolic consumption, and tumors metabolically rewired by knocking down the phosphofructokinase (Pfkm) gene displayed a decrease in PD-1+ cell infiltration. Collectively, we introduced pancreatic juice as a valuable source of metabolic variables that could contri- bute to differential diagnosis. The correlation of metabolic markers with immune infiltration suggests that upfront evaluation of the metabolic profile of PDAC patients could foster the introduction of immunotherapeutic approaches for pancreatic cancer.</p> <p> </p>
Long-Term Study of Cerebral Glucose Metabolism in Huntington's Disease
ClinicalTrials.gov study NCT00004753. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats [human]
GEO Series GSE261149. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Deacetylation of Sirt2 regulates PKM2 ubiquitination and its effect on liver glucose metabolism
GEO Series GSE229161. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
FGFR inhibition blocks NF-ĸB-dependent glucose metabolism and confers metabolic vulnerabilities in cholangiocarcinoma
GEO Series GSE241735. Homo sapiens. 30 samples. Type: Expression profiling by high throughput sequencing.
Ginsenoside compound K plays an anti-inflammatory effect without inducing glucose metabolism disorder in adjuvant-induced arthritis rats
GEO Series GSE261056. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
Glucose metabolism regulates human cortical cell diversification and maturation
GEO Series GSE309759. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Golden Pompano (Trachinotus blochii) improves tolerance to acute hypoxic stress by changing the mode of glucose and lipid metabolism
GEO Series GSE163685. Trachinotus blochii. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional and metabolic effects of glucose on S. pneumoniae sugar metabolism
GEO Series GSE70648. Streptococcus pneumoniae D39. 14 samples. Type: Expression profiling by array.
Oxidative stress, altered glucose metabolism and inflammation contribute to the retinal phenotype in the choroideremia zebrafish
GEO Series GSE254948. Danio rerio. 14 samples. Type: Expression profiling by high throughput sequencing.
Extracellular matrix remodeling regulates glucose metabolism through TXNIP destabilization
GEO Series GSE105034. Homo sapiens. 9 samples. Type: Expression profiling by array.
Glucose PTS modulates pyruvate metabolism, bacterial fitness, and microbial ecology in oral biofilm
GEO Series GSE209672. Streptococcus sanguinis SK36. 6 samples. Type: Expression profiling by high throughput sequencing.
Liver-specific knockdown of class IIa HDACs has limited efficacy on glucose metabolism but entails severe organ side effects in mice
GEO Series GSE154554. Homo sapiens. 16 samples. Type: Expression profiling by array.
The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression
GEO Series GSE291591. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
FBXW7 coordinates postprandial muscle glucose metabolism and maintenance of skeletal muscle mass
GEO Series GSE140503. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Sleep apnea and glucose metabolism
GEO Series GSE480. Mus musculus. 20 samples. Type: Expression profiling by array.
Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis
GEO Series GSE106855. Homo sapiens. 4 samples. Type: Expression profiling by array.
Altered adipose lipid mobilization predicts long-term weight gain and impaired glucose metabolism
GEO Series GSE113080. Homo sapiens. 38 samples. Type: Expression profiling by array.
A low meal frequency improves 24h metabolic and gene expression profiles in subjects with impaired glucose tolerance (PBMC)
GEO Series GSE52026. Homo sapiens. 61 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.