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Dataset results
565 results for “Metabolic response;”
Morphological differentiation and secondary metabolism responses of Streptomyces coelicolor A3(2) to simulated microgravity based on comparative transcriptomics.
GEO Series GSE53748. Streptomyces coelicolor A3(2). 6 samples. Type: Expression profiling by array.
The intestinal clock controls host’s metabolic response to diet by driving intestinal metabolic functions and the fiber-dependent microbiome
GEO Series GSE229963. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Predictive and Prognostic Role of Metabolic Response in Patients With Stage III NSCLC Treated With Neoadjuvant Chemotherapy."
<p>INTRODUCTION:</p> <p>The purpose of this study was to assess the predictive and prognostic role of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in candidates with stage III non-small-cell lung cancer (NSCLC) to neoadjuvant chemotherapy.</p> <p>PATIENTS AND METHODS:</p> <p>Sixty-six patients with stage III NSCLC treated with induction chemotherapy from March 2013 to December 2017 were retrospectively identified. Response assessment were evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 and European Organisation for Research and Treatment of Cancer (EORTC) criteria. 18F-FDG PET/CT metabolic parameters were analyzed as absolute values as well as percentage changes (Δ) between 2 consecutive scans, for primary tumor (T) and for regional lymph nodes (N). All clinical variables and metabolic parameters were compared with treatment response and correlated with progression-free survival (PFS) and overall survival (OS), based on a median follow-up of 9.4 months.</p> <p>RESULTS:</p> <p>Post-induction therapy standardized uptake value (SUV)max_T, SUVmean_T, metabolic tumor volume (MTV_T), and total lesion glycolysis of the tumor (TLG_T) varied significantly between responders and non-responders (6.6 vs. 13.8; P = .001; 4.2 vs. 8.1; P < .001; 6 vs. 17.9; P = .002; and 24.1 vs. 136.3; P < .001, respectively). Likewise, percentage changes (Δ_T) were significantly different between the 2 groups (P < .001). Along with primary tumor, also post-SUVmax_N, post-SUVmean_N, and post-TLG_N (P = .024, P = .015, and P = .024, respectively), as well as all percentage changes (Δ_N) were different between responders and non-responders. RECIST 1.1 and EORTC response classifications were discordant in 27 patients (40.9%; κ = 0.265; P = .003). On multivariate analysis, post-TLG_N was an independent predictor for both PFS and OS, whereas RECIST 1.1 was a predictor only for OS.</p> <p>CONCLUSIONS:</p> <p>Several metabolic parameters may differentiate responders from non-responders following neoadjuvant chemotherapy in stage III NSCLC. As compared with RECIST 1.1, EORTC seems to be more appropriate for evaluation therapeutic response. Finally, post-TLG_N has significant prognostic information.</p>
Data for: The gut microbiome and the genetic predisposition are driving factors of the metabolic response to a dietary intervention – an integrative multi-omics analysis of a randomized trial in obese adults
<p><span>A</span><span> plant-based</span><span> diet </span><span>may contribute to </span><span>reducing</span><span> cardiometabolic risk. We conducted a 6-week</span><span>, randomized,</span><span> </span><span>dietary intervention trial</span><span> comparing </span><span>the </span><span>effect</span><span>s</span><span> of </span><span>two plant-based diets on </span><span>lipid </span><span>metabolism and the gut-brain axis. <span>120 obese adults (</span>59 ± 1 years, 70 females) consumed an isoenergetic Nordic (ND) or a vegetarian diet (VD) or maintained their habitual diet (control group). At baseline and after six weeks, deep metabolic characterization was performed, including measurement of glucagon-like peptide 1 (GLP-1), postprandial lipid metabolism, genetic make-up, gut microbiome and peripheral immune system composition. <span>ND</span>, but not VD beneficially altered lipid metabolism, mainly in participants with a specific gut microbiome signature and a high genetic predisposition for hyperlipidemia. <span>T</span>he special microbial signatures and the individual genetic risk have a strong impact on metabolic response to a dietary change, pointing towards a personalized nutritional approach in preventing cardiometabolic diseases.<br></span></p>
Histone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
GEO Series GSE54642. Mus musculus. 20 samples. Type: Expression profiling by array.
Post-COVID impairment of memory T cell responses to community-acquired pathogens can be rectified by activating cellular metabolism
GEO Series GSE312633. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Global Analysis of the Transcriptional Response of Chinese cabbage (Brassica rapa ssp. pekinensis) to Methyl Jasmonate Reveals JA Signaling on Enhancement of Secondary Metabolism Pathways
GEO Series GSE51363. Brassica rapa subsp. pekinensis. 2 samples. Type: Expression profiling by high throughput sequencing.
ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma [PDX RNA-seq]
GEO Series GSE275636. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Aging-linked deterioration of RNA metabolism destabilizes the stress response of neurons [RNASeq, RiboSeq]
GEO Series GSE277082. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells
GEO Series GSE65722. Homo sapiens. 9 samples. Type: Expression profiling by array.
Metabolic and transcriptional response to the induction of a heterologous poly-3-hydroxybutyrate pathway in Phaeodactylum tricornutum
GEO Series GSE224880. Phaeodactylum tricornutum CCAP 1055/1. 24 samples. Type: Expression profiling by high throughput sequencing.
TheArf‐GAPProteins AoAge1 and AoAge2 are Required for Mycelial Growth, Conidiation, Stress Responses, Trap Formation, and the Secondary Metabolism inthe Nematode-Trapping Fungus Arthrobotrys oligospor
GEO Series GSE253759. Orbilia oligospora. 24 samples. Type: Expression profiling by high throughput sequencing.
Activation of the Integrated Stress Response by a Jumonji Histone Demethylase Inhibitor Induces Pro-Apoptotic Metabolic Reprogramming in Multiple Myeloma
GEO Series GSE60626. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ATF4-Mediated Metabolic Stress Response as a Therapeutic Vulnerability in Chordoma
GEO Series GSE275637. Homo sapiens. 50 samples. Type: Expression profiling by high throughput sequencing.
The Arf‐GAP Proteins AoAge1 and AoAge2 are Required for Mycelial Growth, Conidiation, Stress Responses, Trap Formation, and the Secondary Metabolism in the Nematode-Trapping Fungus Arthrobotrys oligos
GEO Series GSE215079. Orbilia oligospora. 24 samples. Type: Expression profiling by high throughput sequencing.
Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor
GEO Series GSE248283. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Dynamic transcriptional and metabolic responses in yeast adapting to temperature stress.
GEO Series GSE15352. Saccharomyces cerevisiae; Schizosaccharomyces pombe. 24 samples. Type: Expression profiling by array.
Disruption of Pre-Bötzinger Complex neuropeptidergic tonality controls fear and metabolic response
GEO Series GSE307852. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
MYB24 orchestrates terpene and flavonol metabolisms as light responses to anthocyanin depletion in grape variegated berries
GEO Series GSE198702. Vitis vinifera. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Chronic stress-induced cholesterol metabolism abnormalities promote ESCC tumorigenesis and predict neoadjuvant therapy response
GEO Series GSE286200. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.