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548 results for “cardiac function”
The microRNA expression profile in donation after cardiac death (DCD) livers and its ability to identify primary non function
GEO Series GSE67689. Homo sapiens; synthetic construct. 23 samples. Type: Non-coding RNA profiling by array.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells
GEO Series GSE253058. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Smilax glabra Roxb exerts protective effect on cardiac and mitochondrial function in heart failure rats induced by doxorubicin
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Ten-year follow-up of cardiac function and neural regulation in a group of amateur half-marathon runners
<p>Dataset from De Maria B, de Oliveira Gois M, Catai AM, Marra C, Lucini D, Porta A, Pagani M, Dalla Vecchia LA. Ten-year follow-up of cardiac function and neural regulation in a group of amateur half-marathon runners. Open Heart. 2021 Feb;8(1):e001561. doi: 10.1136/openhrt-2020-001561. PMID: 33563778; PMCID: PMC7875294.</p> <p>Abstract</p> <p><strong>Objective: </strong>In the last years, a debate exists about type, intensity and frequency of physical exercise that is really indicated to protect healthy subjects from cardiovascular disease. Regular physical training has been associated with an improved cardiovascular risk profile, but it has also been demonstrated that strenuous and uncontrolled physical exercise could be dangerous, in terms of increased cardiovascular morbidity and mortality. In the present study, we evaluated a group of 35 amateur half-marathon runners, who were likewise studied 10 years before (B). The results of B suggested that an increased cardiac sympathetic modulation could potentially represent a negative prognostic factor. The aim of this follow-up was to assess the medium-long-term effects of moderate to vigorous physical training on the cardiovascular neural control, cardiac function and occurrence of cardiovascular diseases.</p> <p><strong>Methods: </strong>Each enrolled subject underwent: (1) an interview and physical examination to ascertain the presence of cardiovascular disease; (2) standing test to evaluate the cardiovascular neural control by means of heart rate variability (HRV), arterial blood pressure (AP) variability and baroreflex sensitivity (BRS); (3) transthoracic echocardiography to evaluate cardiac function.</p> <p><strong>Results: </strong>At 10-year follow-up (FU), in this group of middle-aged athletes the occurrence of cardiovascular diseases was low, not unlike that of the overall population. The results of HRV analysis showed a decreased sympathetic and increased vagal modulation directed to the heart, compared with B. In addition, HRV, AP variability and BRS indices showed a physiological response to active standing. Finally, athletes had normal echocardiographic measures.</p> <p><strong>Conclusion: </strong>We conclude that in our group of athletes a regular moderate-vigorous physical training through the 10 years was quite beneficial as the prevalence of sympathetic cardiac modulation observed at B was not accompanied by increased cardiovascular risk, on the contrary a slight prevalence of vagal indices was observed at FU.</p>
Data set related to the article: "The longevity-associated BPIFB4 gene supports cardiac function and vascularization in ageing cardiomyopathy"
<p><strong>Aims</strong></p> <p>The ageing heart naturally incurs a progressive decline in function and perfusion that available treatments cannot halt. However,</p> <p>some exceptional individuals maintain good health until the very late stage of their life due to favourable gene–environment inter-</p> <p>action. We have previously shown that carriers of a longevity-associated variant (LAV) of the BPIFB4 gene enjoy prolonged health</p> <p>spans and lesser cardiovascular complications. Moreover, supplementation of LAV-BPIFB4 via an adeno-associated viral vector im-</p> <p>proves cardiovascular performance in limb ischaemia, atherosclerosis, and diabetes models. Here, we asked whether the LAV-</p> <p>BPIFB4 gene could address the unmet therapeutic need to delay the heart’s spontaneous ageing. </p> <p><strong>Methods and results</strong></p> <p>Immunohistological studies showed a remarkable reduction in vessel coverage by pericytes in failing hearts explanted from elderly patients. This defect was attenuated in patients carrying the homozygous LAV-BPIFB4 genotype. Moreover, pericytes isolated from older hearts showed low levels of BPIFB4, depressed pro-angiogenic activity, and loss of ribosome biogenesis. LAV-BPIFB4 supple- mentation restored pericyte function and pericyte-endothelial cell interactions through a mechanism involving the nucleolar protein nucleolin. Conversely, BPIFB4 silencing in normal pericytes mimed the heart failure pericytes. Finally, gene therapy with LAV-BPIFB4 prevented cardiac deterioration in middle-aged mice and rescued cardiac function and myocardial perfusion in older</p> <p>mice by improving microvasculature density and pericyte coverage.</p> <p><strong>Conclusions</strong></p> <p>We report the success of the LAV-BPIFB4 gene/protein in improving homeostatic processes in the heart’s ageing. These findings open to using LAV-BPIFB4 to reverse the decline of heart performance in older people.</p>
The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
GEO Series GSE235522. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells [Cut & Tag]
GEO Series GSE253057. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Defining cardiac functional recovery in end-stage heart failure at single cell resolution
GEO Series GSE226314. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.