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573
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ShareScore release 0.7.1
Dataset results
573 results for “immune function”
Comprehensive transcriptome profiling and functional analysis of the meagre (Argyrosomus regius) immune system
GEO Series GSE247868. Argyrosomus regius. 12 samples. Type: Expression profiling by high throughput sequencing.
Immune function of the serosa in a hemimetabolous insect egg
GEO Series GSE100429. Oncopeltus fasciatus. 9 samples. Type: Expression profiling by high throughput sequencing.
Study on the Mechanism of Codonopsis pilosula Enhancing Immune Function of Aging Mice Based on lncRNA-mRNA Network
GEO Series GSE150773. Mus musculus. 9 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Engineered Nanobodies Targeting Endogenous Digoxin-like Substances Function as Novel Immune Checkpoints Inhibitors and Enhance Immunotherapy against Cancer Metastasis
GEO Series GSE308027. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Function of Arabidopsis PUB2 and PUB4 in plant immunity
GEO Series GSE158238. Arabidopsis thaliana. 6 samples. Type: Expression profiling by high throughput sequencing.
Developmental programming by maternal obesity alters offspring lifespan and immune function in a diet- and sex-specific manner
GEO Series GSE284632. Drosophila melanogaster. 102 samples. Type: Expression profiling by high throughput sequencing.
PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer
GEO Series GSE167469. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the functional impact of Alzheimer’s Disease-associated variants in resting and proinflammatory immune cells [MPRA]
GEO Series GSE273887. Homo sapiens. 76 samples. Type: Other.
Cancer-associated SF3B1-K700E mutation controls immune responses by regulating Treg function via aberrant Anapc13 splicing
GEO Series GSE267436. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases
GEO Series GSE317904. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer."
<p>Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy. In this context, Vδ2<sup>pos</sup> T cells represent the preferential target of several immunotherapy protocols against solid tumors. However, the impact of both aging and chemotherapy (CHT) on Vδ2<sup>pos</sup> T cells is still unknown. The present study evaluates with multi-parametric flow cytometry the frequencies, terminal differentiation, senescence and effector-functions of peripheral blood and tumor infiltrating Vδ2<sup>pos</sup> T cells purified from liver metastases (CLM) of patients affected by colorectal cancer (CRC) compared to those of sex- and age-matched healthy donors. The peripheral blood of CLM patients underwent CHT is characterized by decreased amounts of Vδ2<sup>pos</sup> T cells showing a relative increase of terminally-differentiated CD27<sup>neg</sup>/CD45RA<sup>pos</sup> (T<sub>EMRA</sub>) cells. The enrichment of this latter subset is associated with an increased expression of the senescent marker CD57. The acquisition of CD57 on T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells is also coupled with impairments in cytotoxicity and production of TNF-α and IFN-γ. These features resemble the acquisition of an immune-senescent profile by Vδ2<sup>pos</sup> T cells from CLM patients that received CHT, a phenomenon that is also associated with the loss of the co-stimulatory marker CD28 and with the induced expression of CD16. The group of CLM patients underwent CHT and older than 60 years old showed higher frequencies of CD57<sup>pos</sup> and T<sub>EMRA</sub> Vδ2<sup>pos</sup> T cells. Similar results were found for tumor infiltrating Vδ2<sup>pos</sup> T cell subset purified from CLM specimens of patients treated with CHT. The toxicity of CHT regimens also affects the homeostasis of Vδ2<sup>pos</sup> T cells by inducing higher frequencies of circulating CD57<sup>pos</sup> T<sub>EMRA</sub> subset in CLM underwent CHT and younger than 60 years old. Taken together, our data demonstrate that the enrichment of senescent Vδ2<sup>pos</sup> T cells in CLM patients is not only induced by patients' aging but also by the toxicity of CHT that further accelerates the accumulation of CD57<sup>pos</sup> T<sub>EMRA</sub> cells highly dysfunctional in their anti-tumor activities. These results are important to both predict the clinical outcome of CLM and to optimize those protocols of cell cancer immunotherapy employing unconventional Vδ2<sup>pos</sup> T cells.</p>
The Effct of Chitooligosaccharide on Immune Function in Healthy Adults
ClinicalTrials.gov study NCT00468962. IPD Sharing: Not stated. Countries: 0. Publications: 0.
HVEM in Acute Lymphocytic Leukemia Facilitates Tumor Immune Escape by Inhibiting CD8+ T Cell Function
GEO Series GSE261710. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart
GEO Series GSE236358. Mus musculus. 6 samples. Type: Expression profiling by array.
An Engineered IL-15 Cytokine Mutein Fused to an Anti-PD-1 Antibody Improves Intratumoral T Cell Function and Anti-tumor Immunity
GEO Series GSE160579. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Advancing the fathead minnow (Pimephales promelas) as a model for immunotoxicity testing/Consequences of early life stage thyroid suppression on long term immune function in the fathead minnow (Pimeph
GEO Series GSE146105. Pimephales promelas. 16 samples. Type: Expression profiling by high throughput sequencing.
Functional division of insect blood cells in immunity by single-cell RNA sequencing
GEO Series GSE308201. Spodoptera exigua. 2 samples. Type: Expression profiling by high throughput sequencing.
Specific oncogenic drivers differently shaped the composition and functional diversity of immune cells in the microenvironment of experimental gliomas
GEO Series GSE269545. Mus musculus. 4 samples. Type: Other.
Two unequally redundant 'helper' immune receptor families mediate Arabidopsis intracellular 'sensor' immune receptor functions
GEO Series GSE151885. Arabidopsis thaliana. 305 samples. Type: Expression profiling by high throughput sequencing.
Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade
GEO Series GSE132036. Mus musculus. 9 samples. Type: Other; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.