Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,189
datasets available to search
ShareScore release 0.9.0
Dataset results
1,189 results for “randomized clinical trial”
EFFECT OF FRENCH MARITIME PINE BARK EXTRACT ON ATTENTION-DEFICIT HYPERACTIVITY DISORDER: A RANDOMIZED CLINICAL TRIAL.
<p>This is a dataset from a phase III, randomised, double-blind, placebo and active product controlled, multicentre clinical trial with three parallel treatment arms to compare effects on ADHD and ADD behaviour between Pycnogenol®, MPH (Medikinet® Retard) and placebo, using the ADHDRating Scale (ADHD-RS/ARS) as a primary outcome measure.</p> <p>Evaluations were performed in weeks 5 and 10, as compared to baseline. Two visits with similar evaluations were conducted: at baseline and after 10 weeks. Next to baseline and final evaluations, an extra evaluation of behaviour and physical symptoms was conducted in week 5 by means of questionnaires. The trial population will consists of ADHD and ADD patients recruited at the University Hospitals of Antwerp (UZA) and Ghent (UZ Ghent) and the Hospital Network Antwerp (ZNA), Belgium. Participants were randomised, stratified by trial centre, to one of the three treatment arms (placebo, Pycnogenol®, or Medikinet® Retard) by randomization.com randomisation software. Published protocol: Verlaet AAJ, Ceulemans B, Verhelst H, Van West D, De Bruyne T, Pieters L, Savelkoul HFJ, Hermans N. Effect of Pycnogenol® on attention-deficit hyperactivity disorder (ADHD): study protocol for a randomised controlled trial. Trials (2017), 18(1).</p> <p>As the primary objective is to assess the efficacy of Pycnogenol® for improving ADHD and ADD behaviour as rated by teachers compared to placebo and Medikinet® Retard, the primary outcome is the summed ADHD score of the ADHD-RS as rated by teachers. Teachers filled out this questionnaire before the start of the intervention and after 5 and 10 weeks. Secondary outcomes ADHD/ADD behaviour Secondary outcomes related to ADHD/ADD behaviour are:</p> <p>Summed ADHD score of the ADHD-RS, rated by parents</p> <p>Summed ADHD score of the Social-emotional Questionnaire (SEQ), rated by parents and teachers</p> <p>Scores on ADHD subscales of the ADHD-RS and SEQ, rated by parents and teachers (hyperactivity, impulsivity and inattention)</p> <p>Percentage of responders rated by parents and teachers, defined as participants with a reduction of at least 20% of their baseline summed ADHD-RS s</p> <p>Social behaviour problems subscale of the SEQ, rated by parents and teachers, to evaluate to what extent symptoms of ODD and CD are displayed</p> <p>Anxiety subscale of the SEQ, rated by parents and teachers, to evaluate symptoms of general anxiety, social anxiety and anxiety-depression</p> <p>Physical and sleep complaints, including various potential side effects, measured by the Physical Complaints Questionnaire (PCQ)</p> <p>Dietary habits of participants were assessed by a Food Frequency Questionnaire (FFQ).</p> <p>The ADHD-RS (ARS) is a validated, internationally accepted questionnaire. Its 9 inattention (IA) and 9 hyperactivity and impulsivity (HI) items, rated on a four-point rating scale (never/seldom 0, sometimes 1, often 2, or very often 3), are based on the DSM. The ADHD-RS was used in previous trials as well. </p> <p>Besides ADHD, the Social-Emotional Questionnaire (SEQ) assesses core symptoms of other social-emotional problems (social behaviour problems, anxiety and autism). Its 72 questions are based on the DSM and rated on a five-point scale (never 0, less than once a month 1, every month 2, every week 3, or (almost) every day 4). The ADHD score can be subdivided into an hyperactivity (H) score, impulsivity (I) score and inattention (IA) score, each based on 6 questions.</p> <p>The PCQ enquires physical and sleep complaints, for instance related to pain, unusual thirst/perspiration, asthma or rhinitis, skin problems, tiredness, gastrointestinal problems and sleep problems. Questions include potential adverse effects and are rated on a five-point scale. In addition to several stand-alone questions, various questions can be combined (e.g. total pain: headache, stomach ache and growing pains). Each item is rated on a five-point scale (never 0, less than once a month 1, every month 2, every week 3, or (almost) every day 4). </p> <p>The FFQ consisted of 50 questions on different food groups to be rated on a nine-point scale (never 0, less than once a month 1, 1-3 times a month 2, once a week 3, 2-4 times a week 4, 5-6 times a week 5, once a day 6, 2-3 times a day 7, more than 3 times a day 8) to assess global dietary habits (e.g. how often a participant consumes fresh fruits or vegetables).</p> <p>Researchers involved in digitalizing questionnaire answers and statistics were blind for the participant groups. In case of >2 missing answers regarding a (sub)score within a patient, this (sub)score was set to missing. Participants were excluded from analyses only for those outcomes without any data available. Several teacher questionnaires were missing due to teachers never responding/not responding anymore, starting/ending the study during the summer holiday, covid-19 (homeschooling), or a combination of these.</p> <p>Data in SPSS were directly used for statistics. Data in excel are raw data.</p>
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers
ClinicalTrials.gov study NCT02312596. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomized, Double-blind, Multi-center, Active-controlled, Phase 3 Clinical Trial to Evaluate the Efficacy and Safety of Combination Therapy of THP-00101, THP-00102, and THP-00103 in Subjects With T
ClinicalTrials.gov study NCT06647745. IPD Sharing: UNDECIDED. Countries: 2. Publications: 0.
Clinical Trial of The Boosting Effect of Transcranial Random Noise Stimulation (tRNS) in Cognitive Rehabilitation of Patients With Traumatic Brain Injury
ClinicalTrials.gov study NCT03696381. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy
ClinicalTrials.gov study NCT06702657. IPD Sharing: YES. Countries: 0. Publications: 0.
A Randomized, Double-blinded, Active Controlled Crossover Clinical Trial to Investigate PK, PD and Safety of GBPD002
ClinicalTrials.gov study NCT05585658. IPD Sharing: NO. Countries: 1. Publications: 0.
DIROXIMEL FUMARATE TO REDUCE PERIHAEMATOMAL OEDEMA IN INTRACEREBRAL HAEMORRHAGE: DOUBLE BLIND RANDOMIZED CLINICAL TRIAL
ClinicalTrials.gov study NCT07275515. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
GlutN : Randomized, Double-blind, Crossover Clinical Trial to Confirm the Role of Gluten in Non-celiac Gluten Sensitivity
ClinicalTrials.gov study NCT06347341. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Mechanism of High-Dose Vitamin D Supplementation in Pediatric OAB-Dry: A Randomized Clinical Trial Integrating Urinary Myelin Basic Protein as a Theranostic Biomarker
ClinicalTrials.gov study NCT06489951. IPD Sharing: NO. Countries: 1. Publications: 0.
A Randomized Clinical Trial to Prevent Recurrent CA-MRSA Infection
ClinicalTrials.gov study NCT00560599. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized Trial of Clinical Decision Making in Asymptomatic Carotid Stenosis
ClinicalTrials.gov study NCT01315288. IPD Sharing: Not stated. Countries: 1. Publications: 0.
MFERG Study of HCQ Retinopathy in Lupus Nephritis Patients: A Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT05111158. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Clinical Trial to Assess the Efficacy and Safety of Concomitant Use of Rifampicin and Efavirenz 600 X 800mg
ClinicalTrials.gov study NCT00533390. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Directly Observed Therapy Study to Interpret Clinical Trials of Doxy-PEP
ClinicalTrials.gov study NCT06414408. IPD Sharing: NO. Countries: 1. Publications: 0.
NanoMn®_COVID-19 A Prospective, Multicenter, Randomized, Placebo-controlled, Parallel-group, Double-blind Trial to Evaluate the Clinical Efficacy of NanoManganese® on Top of Standard of Care, in Adult
ClinicalTrials.gov study NCT05451654. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized, Open-label, Single-dose, Crossover Clinical Trial to Evaluate the Food Effect on the Pharmacokinetics of Dilatrend SR 64mg Capsule After Oral Administration in Healthy Male Volunteers
ClinicalTrials.gov study NCT01340248. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of Cinnamomum Verum for Induction of Labor. Double Blind Randomized Clinical Trial
ClinicalTrials.gov study NCT06164613. IPD Sharing: YES. Countries: 1. Publications: 0.
Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Drug Resistant Epilepsy Single Center, Non-randomized, Phase I Clinical Trial
ClinicalTrials.gov study NCT06638970. IPD Sharing: YES. Countries: 1. Publications: 0.
Medication Adherence in Kidney Transplant Patients: SystemCHANGE™ Results of the Turkish MAGIC Randomized Clinical Trial
ClinicalTrials.gov study NCT06106854. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Randomized Clinical Trial Aimed at Comparing Unclamped Robotic Partial Nephrectomy With or Without Renorrhaphy
ClinicalTrials.gov study NCT06846112. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.