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1,237 results for “treatment outcome”
The induction of core pluripotency master regulators in cancers defines poor clinical outcomes and treatment resistance
GEO Series GSE117193. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Profile of Breast Tissue of Premenopausal Women Following Treatment with Progesterone Receptor Modulator: Secondary Outcomes of a Randomized Controlled Trial
GEO Series GSE252145. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Data from: Mobile phone reminders and peer counseling improve adherence and treatment outcomes of patients on ART in Malaysia: a randomized clinical trial
Background: Adherence to treatment remains the cornerstone of long term viral suppression and successful treatment outcomes among patients receiving Antiretroviral Therapy (ART). Objective(s): Evaluate the effectiveness of mobile phone reminders and peer counseling in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. Methods: A single-blind, parallel group RCT conducted in Hospital Sungai Buloh, Malaysia in which 242 adult Malaysian patients were randomized to intervention or control groups. Intervention consisted of a reminder module delivered through SMS and telephone call reminders by trained research assistants for 24 consecutive weeks (starting from date of ART initiation), in addition to adherence counseling at every clinic visit. The length of intended follow up for each patient was 6 months. Data on adherence behavior of patients was collected using specialized, pre-validated Adult AIDS Clinical Trial Group (AACTG) adherence questionnaires. Data on weight, clinical symptoms, CD4 count and viral load tests were also collected. Data was analyzed using SPSS version 22 and R software. Repeated measures ANOVA, Friedman's ANOVA and Multivariate regression models were used to evaluate efficacy of the intervention. Results: The response rate after 6 months follow up was 93%. There were no significant differences at baseline in gender, employment status, income distribution and residential location of respondents between the intervention and control group. After 6 months follow up, the mean adherence was significantly higher in the intervention group (95.7; 95% CI: 94.39–96.97) as compared to the control group (87.5; 95% CI: 86.14–88.81). The proportion of respondents who had Good (>95%) adherence was significantly higher in the intervention group (92.2%) compared to the control group (54.6%). A significantly lower frequency in missed appointments (14.0% vs 35.5%) (p = 0.001), lower viral load (p = 0.001), higher rise in CD4 count (p = 0.017), lower incidence of tuberculosis (p = 0.001) and OIs (p = 0.001) at 6 months follow up, was observed among patients in the intervention group. Conclusion: Mobile phone reminders (SMS and telephone call reminders) and peer counseling are effective in improving adherence and treatment outcomes among HIV positive patients on ART in Malaysia. These findings may be of potential benefit for collaborative adherence planning between patients and health care providers at ART commencement.
Data from: Sporadic late-onset nemaline myopathy: clinical spectrum, survival and treatment outcomes
OBJECTIVES: To describe the clinical phenotype, long-term treatment outcome and overall survival of sporadic late onset nemaline myopathy (SLONM) with or without a monoclonal protein (MP). METHODS: we conducted a retrospective chart review of patients seen between September 2000 and June 2017 and collected clinical, laboratory and survival data. Treatment response was classified as mild, moderate, or marked as adjudged by predefined criteria. RESULTS: We identified 28 patients with SLONM, 17 (61%) had an associated MP. Median age at symptom onset was 62 years. Diagnosis was often delayed by a median of 35 months from symptom onset. There was no difference in clinical or laboratory features between patients with or without MP. Although the majority of patients had proximal or axial weakness at onset, about 18% of patients had atypical presentations. 7/9 (78%) patients receiving intravenous immunoglobulin (IVIG), 6/8 (75%) receiving hematologic therapy as either autologous stem cell transplant (ASCT), or chemotherapy and 1/8 (13%) receiving immunosuppressive therapies responded to treatment (p=0.001). All 3 patients with marked response were treated with IVIG, 2 of them had a MP. The 5-year and 10-year overall survivals from symptom onset were 92% and 68% respectively, with no difference between patients with or without MP. CONCLUSIONS: SLONM has a wide spectrum of clinical presentations. In this contemporary case series, overall survival of patients did not seem to be affected by the presence of a MP. Initial treatment with IVIG is reasonable in all patients, followed by ASCT or chemotherapy as second-line therapy in patients with an associated MP.
The impact of obesity on orthodontic treatment outcome in adolescents: a prospective clinical cohort study
<p>Dataset for all analyses of the paper</p>
One-Year Outcome After Endovascular Treatment for Acute Basilar Artery Occlusion
<p><b>Objective: </b>To report the results of clinical follow-up at one year among patients in the BASILAR registry, a prospective registry that consecutively enrolled stroke patients with acute basilar artery occlusion from 47 comprehensive stroke centers in China between January 2014 and May 2019.</p> <p><b>Methods:</b> Patients in the BASILAR study received either conventional treatment or endovascular treatment. We assessed clinical outcomes in patients one year after enrolment into the BASILAR registry.<b> </b>The primary outcome was the modified Rankin scale score at one year, assessed as a common odds ratio using ordinal logistic regression shift analysis adjusted for pre-specified prognostic factors. Secondary outcomes included the modified Rankin scale-based outcome group at one year (0 to 1 [excellent outcome], 0 to 2 [good outcome], or 0 to 3 [favorable outcome]) and death from any cause.</p> <p><b>Results: </b>Of the 829 patients enrolled in the original BASILAR study, one-year data were available for 785 patients (94.7%). The distribution of outcomes on the modified Rankin scale favored endovascular treatment over conventional treatment (adjusted common odds ratio, 4.50; 95% confidence interval, 2.81 to 7.29; P < 0.001). The cumulative one-year mortality rate was 54.6% in the endovascular treatment group versus 83.5% in the conventional treatment group (adjusted hazard ratio, 4.36; 95% confidence interval, 2.69 to 7.29; P < 0.001).</p> <p><b>Conclusions: </b>The beneficial effect of endovascular treatment on functional outcome at one year in patients with acute basilar artery occlusion is similar to that reported at 90 days in the original study.</p> <p><b>Clinical trial identifiers Numbers</b>: ChiCTR-180001475</p>
A Study of Treatment Patterns and Clinical Outcomes in First Line Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck (1L R/M SCCHN) Participants in Europe
ClinicalTrials.gov study NCT05123950. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating Treatment Outcomes Using Darolutamide and Androgen Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer.
ClinicalTrials.gov study NCT06660862. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)
ClinicalTrials.gov study NCT04457674. IPD Sharing: YES. Countries: 1. Publications: 0.
Treatment Outcomes After Receiving Conventional Clasp or Precision Attachment Removable Partial Dentures.
ClinicalTrials.gov study NCT02924142. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Hypertensive Urgency Treatment and Outcomes in a Northeast Thai Population
ClinicalTrials.gov study NCT03484312. IPD Sharing: YES. Countries: 1. Publications: 0.
Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia
ClinicalTrials.gov study NCT04432285. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Clinical and Radiographic Outcomes of Meniscal Lesion Treatment Using Collagen Scaffolds (CMI)
ClinicalTrials.gov study NCT06597357. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Patients With Lower-Risk Myelodysplastic Syndromes Treated With Luspatercept
ClinicalTrials.gov study NCT07075406. IPD Sharing: NO. Countries: 1. Publications: 0.
Patient-Centered Outcomes in the Surgical Treatment of Uterovaginal Prolapse
ClinicalTrials.gov study NCT05063331. IPD Sharing: YES. Countries: 1. Publications: 0.
Longterm Functional Outcomes in Patients Undergoing Organ Preserving Treatment for Rectal Cancer With or Without Local Excision After Chemoradiotherapy
ClinicalTrials.gov study NCT06249672. IPD Sharing: NO. Countries: 1. Publications: 0.
Role of Surgery in Treatment of Recurrent Brian Glioma:Prognostic Factors and Outcome
ClinicalTrials.gov study NCT04562077. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes
ClinicalTrials.gov study NCT04698226. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Investigation on the Outcome of Episealer Talus Post-operation for Treatment of Focal Osteochondral Defects
ClinicalTrials.gov study NCT06225674. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Oncological and Perioperative Outcomes of Laparoscopic Versus Robotic Partial Nephrectomy for Treatment of Renal Tumors.
ClinicalTrials.gov study NCT06424080. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.