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592
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ShareScore release 0.9.0
Dataset results
592 results for “tendon”
Epigenetic Analysis of Wild Type and Mkx-/- Tendon by Next Generation Sequencing
GEO Series GSE102925. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mechanical shear effects on flexor tendon cells
GEO Series GSE4096. Mus musculus. 2 samples. Type: Expression profiling by array.
RNA-seq analysis of Scx-lineage cell depletion to investigate tendon cell functions during flexor tendon healing
GEO Series GSE156157. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Platelet-derived growth factor receptor signaling is required for postnatal tendon growth
GEO Series GSE95794. Mus musculus. 10 samples. Type: Expression profiling by array.
Expression data from mouse limb tendon cells during development.
GEO Series GSE54207. Mus musculus. 9 samples. Type: Expression profiling by array.
Effects of 32 Days Aboard the ISS on Gastrocnemius Tendon Nanomechanics (Gastrocnemius tendon, RR-1 and Atomic Force Microscopy)
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to internal stimuli have been extensively researched, the impact of environmental factors (such as microgravity) on its structure and function at the nanoscopic scale (i.e., fibril level) remains largely unexplored. The purpose of this study was to determine the effects of 32 days (d) aboard the International Space Station (ISS) on murine tendon collagen fibril morphology and nanomechanics (Young’s Modulus, YM). Gastronemius tendon samples from 16wk old female C57BL/6J mice aboard NASA Rodent Research-1 underwent chemical processing and mechanical isolation. Subsequently, collagen fibrils (n equals 17) were studied via atomic force microscopy (AFM, JPK NanoWizard 4a) to compare the morphology (diameter, height) and nanomechanics (average YM) between spaceflight (SF) and ground control (GC) mouse tendon samples. The qp-BioAC-CB1 cantilever (spring constant: 0.3 N/m, tip radius: 10µm) was used under quantitative imaging mode (Qi) for all force and morphological measurements. The data from 17 micrographs (SF n equals 5; GC n equals 12) was processed via the JPK Data Processing Software (Version 6.4.5.), and finally analyzed via Gwyddion (Version 2.62). To our knowledge, this is the first investigation to use AFM QI-mode on tendon collagen fibrils after spaceflight. Mean fibril size and YM were similar between Space Flight (SF) and Ground Control (GC) mouse tendon fibrils after 32 days of space flight; these results suggest that collagen fibrils may require more time to adapt to changes in their environment, and/or more rapid changes may take place at different levels of the collagen hierarchy. This data provides valuable insights into mammalian tissue adaptations during spaceflight, and future research should continue these investigations with longer-duration missions to build a time-course of tendon adaptations to microgravity. This dataset includes results from atomic force microscopy using gastronemius tendon tissue.
Effects of 32 Days Aboard the ISS on Quadricep Tendon Nanomechanics (Quadricep femoris tendon, RR-1 and Atomic Force Microscopy)
Collagen is an essential component of connective tissue and plays a crucial role in elasticity, stability, and force distribution. While the adaptations of tendon to internal stimuli have been extensively researched, the impact of environmental factors (such as microgravity) on its structure and function at the nanoscopic scale (i.e., fibril level) remains largely unexplored. The purpose of this study was to determine the effects of 32 days (d) aboard the International Space Station (ISS) on murine tendon collagen fibril morphology and nanomechanics (Young’s Modulus, YM). Quadriceps tendon samples from 16wk old female C57BL/6J mice aboard NASA Rodent Research-1 underwent chemical processing and mechanical isolation. Subsequently, collagen fibrils (n equals 38) were studied via atomic force microscopy (AFM, JPK NanoWizard 4a) to compare the morphology (diameter, height) and nanomechanics (average YM) between spaceflight (SF) and ground control (GC) mouse tendon samples. The qp-BioAC-CB1 cantilever (spring constant: 0.3 N/m, tip radius: 10µm) was used under quantitative imaging mode (Qi) for all force and morphological measurements. The data from 17 micrographs (SF n equals 23; GC n equals 15) was processed via the JPK Data Processing Software (Version 6.4.5.), and finally analyzed via Gwyddion (Version 2.62). To our knowledge, this is the first investigation to use AFM QI-mode on tendon collagen fibrils after spaceflight. Mean fibril size and YM were similar between SF and GC mouse tendon fibrils after 32 days of space flight; these results suggest that collagen fibrils may require more time to adapt to changes in their environment, and/or more rapid changes may take place at different levels of the collagen hierarchy. This data provides valuable insights into mammalian tissue adaptations during spaceflight, and future research should continue these investigations with longer-duration missions to build a time-course of tendon adaptations to microgravity. All results derived are from atomic force microscopy using quadriceps femoris tendon tissue.
Humanoid robot upregulates cellular stress pathways in tendon tissue engineering
GEO Series GSE273566. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
N-Acetyl-L-cysteine facilitates tendon repair and promotes the tenogenic differentiation of tendon stem/progenitor cells by enhancing the integrin α5/β1/PI3K/AKT signaling
GEO Series GSE218038. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of optogenetic-induced muscle loading on the transcriptomics of murine Achilles tendon and calcaneus
GEO Series GSE226742. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Angiopoietin-like 4 enhances the ability of tendon fibroblasts to undergo proliferation and migration
GEO Series GSE80356. Homo sapiens. 9 samples. Type: Expression profiling by array.
Spatial Gene Expression in the Adult Rat Patellar Tendon
GEO Series GSE248646. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing; Other.
RNA-sequencing of human tendon after injury
GEO Series GSE108933. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Nonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects
GEO Series GSE190685. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Electrospun scaffold micro-architecture induces an activated transcriptional phenotype within tendon fibroblasts. Bulk RNA-seq data.
GEO Series GSE190085. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing of sheep infraspinatus muscle after two weeks of tendon release
GEO Series GSE144394. Ovis aries. 6 samples. Type: Expression profiling by high throughput sequencing.
Depletion of Scleraxis-lineage cells during tendon healing transiently impairs multi-scale restoration of tendon structure during early healing
GEO Series GSE213033. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
CTRP3 exacerbates tendinopathy by dysregulating tendon stem cell differentiation and altering extracellular matrix composition [array]
GEO Series GSE180368. Mus musculus. 10 samples. Type: Expression profiling by array.
Single-cell RNA-seq of the tendon enthesis cells
GEO Series GSE182997. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Rapamycin limits peritendinous fibrosis but does not affect intratendinous healing in a rodent Achilles tendon injury model
GEO Series GSE293831. Rattus norvegicus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.