Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
5,826
datasets available to search
ShareScore release 0.9.0
Dataset results
5,826 results for “Randomized trial”
Occlusal outcome of fixed appliance orthodontic treatment: a systematic review with meta-analyses of randomized trials
<p>Dataset for all analyses.<br>Dataset will be initially made available to editor and peer-reviewers during the journal peer-review stage.<br>Upon publication this will be made available to all without any restrictions.</p>
The ACTonHEART Study: a Randomized Controlled Clinical Trial of a short intervention based on Acceptance and Commitment Therapy vs. usual care for cardiac rehabilitation patients with coronary heart disease.
<p>The ACTonHEART study evaluates the effectiveness of adding an ACT-based intervention to usual secondary prevention care of coronary heart disease, in order to promote healthy lifestyle changes and improve psychological wellbeing and quality of life among CR patients; psychological flexibility was a hypothesized mechanism of change.</p> <p>Ninety-two patients were enrolled and randomized, following an unbalanced randomization ratio of 2:1, to the ACT group (N= 59) and the control group (N= 33). The control group completed standard CR (Usual Care; UC) and the experimental subjects participated in the ACTonHEART group intervention in addition to standard CR. The ACTonHEART intervention consisted of three, two-hour, group sessions, focused on integrating acceptance and mindfulness skills into educational topics on heart-healthy behaviors. The primary study hypothesis is that the ACTonHEART group is superior to the UC group in the following primary outcome measures: LDL-cholesterol, resting systolic blood pressure, body mass index, and psychological wellbeing.</p> <p>Participants were assessed at baseline and at the end of the rehabilitation period. Linear mixed models analyses were used to detect the group x time interaction. Across all outcome variables, no time x treatment effect was found. The results of this study may inform the future implementations of ACT in the cardiac rehabilitation context.</p> <p>Corresponding author: Chiara Spatola (chiara.spatola@unime.it)</p>
Data for: The gut microbiome and the genetic predisposition are driving factors of the metabolic response to a dietary intervention – an integrative multi-omics analysis of a randomized trial in obese adults
<p><span>A</span><span> plant-based</span><span> diet </span><span>may contribute to </span><span>reducing</span><span> cardiometabolic risk. We conducted a 6-week</span><span>, randomized,</span><span> </span><span>dietary intervention trial</span><span> comparing </span><span>the </span><span>effect</span><span>s</span><span> of </span><span>two plant-based diets on </span><span>lipid </span><span>metabolism and the gut-brain axis. <span>120 obese adults (</span>59 ± 1 years, 70 females) consumed an isoenergetic Nordic (ND) or a vegetarian diet (VD) or maintained their habitual diet (control group). At baseline and after six weeks, deep metabolic characterization was performed, including measurement of glucagon-like peptide 1 (GLP-1), postprandial lipid metabolism, genetic make-up, gut microbiome and peripheral immune system composition. <span>ND</span>, but not VD beneficially altered lipid metabolism, mainly in participants with a specific gut microbiome signature and a high genetic predisposition for hyperlipidemia. <span>T</span>he special microbial signatures and the individual genetic risk have a strong impact on metabolic response to a dietary change, pointing towards a personalized nutritional approach in preventing cardiometabolic diseases.<br></span></p>
Effects of Dualsite Anodic tDCS on Lower Limbs Function in Patients After Stroke: Randomized, Double-blind, Placebo-controlled, Crossover Trial
<p>https://docs.google.com/spreadsheets/d/1gyZvGAK0t3D83jHWWULAdhNmDYWvHa8nvzGJeLP4oVk/edit#gid=1006784133</p>
Dataset related to: "Home-based exercises with teleconsultation following hospitalization for COVID-19 pneumonia: a randomized controlled trial"
<p>We provide the raw data used for the following article:</p> <p>Paneroni M, Scalvini S, Perger E, Zampogna E, Govetto S, Oliva FM, Matrone A, Bernocchi P, Rosa D, Vitacca M. <strong>Home-based exercise program for people with residual disability following hospitalization for COVID-19: Randomized control trial. </strong>Ann Phys Rehabil Med. 2024 Mar;67(2):101815. doi: 10.1016/j.rehab.2023.101815. </p> <p><strong>ABSTRACT</strong></p> <p><em><span>Background</span></em><span>: In post-COVID-19 individuals with effort intolerance or hypoxia at rest and/ or during exercise, the best exercise program after in-hospital rehabilitation remains unknown.</span></p> <p><em><span>Objective:</span></em><span> We aimed to evaluate the efficacy of a Home-based Exercise Program with teleconsultation (Intervention group) to improve effort tolerance. </span></p> <p><em><span>Methods</span></em><span>: This is a multicenter randomized controlled trial. We included COVID-19 individuals after rehabilitation attempts with a) less than 70% of the predicted distance during the Six-Minute Walking test (6MWT) and/or b) oxygen desaturation all day long or during effort.</span><span> Effort tolerance was evaluated by 6MWT (primary outcome). Secondary outcomes were dyspnea, fatigue, spirometry, respiratory muscle evaluations, and oxygenation. The</span><span> Intervention group performed one month of a self-administered exercise program and bi-weekly physiotherapist video calls; the Control group was free to conduct physical activity as usual. Exercise intensity was set into 4 levels according to disability and oxygen desaturation, and progressively increased ranging from low (walking, free-body exercise, sit-to-stand, balance exercises), to higher (speed walking with a pedometer, cycle ergometer, strengthening exercises) intensity. </span></p> <p><em><span>Results</span></em><span>: We included 79 participants, 40 in the Intervention and 39 in the Control group [mean (SD) 67.1(10.3) years old, 72% male]. No difference in effort tolerance was found after the intervention between groups [Intervention 77.6 (75.4) vs Control 49.5 (73.3) m, p= 0.109]. Participants with 6MWT below the Lower Limit of Normality experienced a better improvement in effort tolerance [Intervention: mean (SD) 120.1 (75.8) vs Control 59.1 (75.6) m, p= 0.035]. After two months, the 6MWT distance in the two groups was similar (Intervention mean (SD) 475.9 (82.4) vs Control 469.2 (118.9) m, p= 0.807). </span></p> <p><em><span>Conclusions</span></em><span>: In post-COVID-19 individuals with a residual disability after a rehabilitation attempt, a home-based exercise program with teleconsultation</span><span> </span><span>leads to a significant benefit on effort tolerance only in participants with severe effort intolerance at baseline. </span></p> <p><span> </span><em><span>Database Registration</span></em><span>: ClinicalTrials.gov number, NCT04821934</span></p> <p><span> </span><em><span>Keywords</span></em><span>: COVID-19; exercise; teleconsultation, healthcare providers</span></p>
Short-term Ketogenic Diet as Compared With Conventional Long-term Trial in Refractory Infantile Spasms: A Randomized, Controlled Study
ClinicalTrials.gov study NCT00968136. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Prospective Evaluation in a Randomized Trial of TAXUS in the Treatment of De Novo Coronary Artey Lesions
ClinicalTrials.gov study NCT00693979. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Application of Computer-assisted Navigation in Total Knee Arthroplasty: A Randomized Pair-matched Double-blind Trial
ClinicalTrials.gov study NCT00982956. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Randomized Phase II Trial of Dose Dense Docetaxel in N+ Breast Cancer
ClinicalTrials.gov study NCT00189670. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Insulin Dependent Gestational Diabetes Mellitus: Randomized Trial of Induction of Labour at 38 and 40 Weeks of Gestation
ClinicalTrials.gov study NCT01256892. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Management of Hyperglycemia in the ER: A Randomized Clinical Trial of a Subcutaneous Insulin Aspart Protocol Coupled With Rapid Initiation of Basal Bolus Insulin Prior to Hospital Admission Versus Usu
ClinicalTrials.gov study NCT00663624. IPD Sharing: Not stated. Countries: 0. Publications: 0.
A Randomized, Open Label, Single Dose, 2-Way Cross-over Clinical Trial to Compare the Safety and Pharmacokinetic Characteristics of Exforge® and G-0081 in Healthy Male Volunteers
ClinicalTrials.gov study NCT01776047. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Neoadjuvant and adjuvant pembrolizumab for advanced high-grade serous carcinoma (NeoPembrOV): A randomized phase II GINECO clinical trial
GEO Series GSE227666. Homo sapiens. 109 samples. Type: Expression profiling by high throughput sequencing.
The infusion of ex vivo, interleukin-15 and -21-activated donor NK cells after haploidentical HCT in high-risk AML and MDS patients—a randomized trial
GEO Series GSE154392. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome Analysis in Human Breast Milk and Blood in a Randomized Trial after Inactivated or Attenuated Influenza Immunization
GEO Series GSE281592. Homo sapiens. 69 samples. Type: Expression profiling by high throughput sequencing.
Alanyl-glutamine in peritoneal dialysis fluids - a randomized controlled phase I/II trial
GEO Series GSE57070. Homo sapiens. 6 samples. Type: Expression profiling by array.
Gene expression analysis of vastus medialis cells after tourniquet-induced ischemia during Total Knee Arthroplasty: A randomized clinical trial
GEO Series GSE124595. Homo sapiens. 20 samples. Type: Expression profiling by array.
Dataset related to article "Cost-effectiveness of second-line diagnostic investigations in patients included in the DANTE trial: a randomized controlled trial of lung cancer screening with low-dose computed tomography."
<p>AIM:</p> <p>The aim of this study was to analyze the economic efficiency of second-line diagnostic investigations in patients with undetermined lung nodules.</p> <p>PARTICIPANTS AND METHODS:</p> <p>A retrospective review of all surgical cases included in the DANTE trial from 2001 to 2006 for lung cancer screening was performed. Overall, 217 patients and 261 lung nodules were analyzed. The cohort was divided into patients investigated with PET and/or computed tomography (CT)-guided biopsy (PET-CTB protocol; N=100), compared with those assessed with serial low-dose CT scans (standard protocol; N=161). Outpatient's and inpatient's costs were expressed in euros and derived from the Italian National Health Service. Ineffective costs were defined as the cost of procedures that lead to avoidable surgical intervention.</p> <p>RESULTS:</p> <p>The diagnostic accuracy of the two protocols was 91% for the standard (sensitivity 100%, specificity 91%, positive predictive value 26%, and negative predictive value 100%) and 90% for the PET-CTB protocol (sensitivity 98%, specificity 81%, positive predictive value 85%, and negative predictive value 97%). Average costs for outpatient's diagnostics were 694 and 1.462 euros, respectively, for the standard and PET-CTB protocol. Average inpatient's costs for both protocols were 12.121 euros. The two protocols showed comparable effectiveness in terms of outpatient's costs (94 and 90%, respectively; P=0.252). Inpatient's costs were effective in 36% of cases monitored according to the standard protocol compared with 85% of patients investigated with PET-CTB protocol. Ineffective costs corresponded to 64 and 15%, respectively (P<0.0001).</p> <p>CONCLUSION:</p> <p>Despite a higher average cost for outpatient's diagnostics, the implementation of PET imaging with or without CT-guided needle biopsy in the workup of suspicious lung nodules results in reduced unnecessary harm and costs related to inpatient's procedures.</p>
Procalcitonin and lung ultrasonography point-ofcare testing to decide on antibiotic prescription in patients with lower respiratory tract infection at primary care level: pragmatic cluster randomized trial
<p>Dataset of the ULTRAPRO cluster-randomized clinical trial. </p>
Loss to follow-up in a randomized controlled trial study for pediatric weight management (EPOC)
<p>This is the data set as supporting information, provided as .sav file.</p> <p>Further information is available on request.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.