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5,946 results for “diabetes type 2”
Vitamin C supplementation reduces expression of circulating miR-451a in poorly controlled type 2 diabetes mellitus
GEO Series GSE154647. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by array.
Single-cell RNA-seq uncovers the early alterations of retina in type 2 diabetes mice
GEO Series GSE205123. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
The role of BAF60C in type 2 diabetes——RNAseq
GEO Series GSE317978. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Distinct hippocampal expression profiles of lncRNAs in obese type 2 diabetes mice exhibiting cognitive impairment
GEO Series GSE151294. Mus musculus. 6 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Micro RNA array analysis in OLETF, a type 2 diabetic rats, and LETO, a non-diabetic control rats
GEO Series GSE99410. Mus musculus; Rattus norvegicus. 6 samples. Type: Expression profiling by RT-PCR.
Gene expression analysis in OLETF, a type 2 diabetic rats, and LETO, a non-diabetic control rats
GEO Series GSE99411. Mus musculus; Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing; Expression profiling by RT-PCR.
Functional interrogation of twenty Type 2 Diabetes-associated genes using isogenic hESC-derived β-like cells
GEO Series GSE228665. Homo sapiens. 139 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; SNP genotyping by SNP array.
Mitochondrial DNA atlas reveals physiopathology of type 2 diabetes
GEO Series GSE136892. Homo sapiens. 40 samples. Type: Genome variation profiling by high throughput sequencing.
Gene Expression Profiles in Skeletal Muscle and Liver of Type 2 Diabetes Rats
GEO Series GSE41832. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
Functional interrogation of twenty Type 2 Diabetes-associated genes using isogenic hESC-derived β-like cells [RNA-Seq]
GEO Series GSE228662. Homo sapiens. 67 samples. Type: Expression profiling by high throughput sequencing.
Long non-coding RNA screening for type 2 diabetes
GEO Series GSE163980. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by array.
Pancreatic β-cell specific Ets-1 inhibition treats type 2 diabetes via revitalized insulin production
GEO Series GSE214924. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene expression profile at single cell level of PBMC from HFD/STZ-induced type 2 diabetic mice
GEO Series GSE274561. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Deciphering the Transcriptomic Landscape of Type 2 Diabetes: Insights from Bulk RNA Sequencing and Single-Cell Analysis [scRNA-seq]
GEO Series GSE280401. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Identification of cross-species preserved cis-regulatory elements containing type 2 diabetes GWAS variants
GEO Series GSE210138. Mus musculus. 386 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hyperglycemia-triggered lipid peroxidation destabilizes STAT4 and impairs anti-viral Th1 responses in type 2 diabetes
GEO Series GSE274826. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Functional interrogation of twenty Type 2 Diabetes-associated genes using isogenic hESC-derived β-like cells [WGS]
GEO Series GSE239329. Homo sapiens. 4 samples. Type: Other.
Dataset related to the article : "The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus"
<p>This record contains raw data related to the article: The Burden of Impaired Serum Albumin Antioxidant Properties and Glyco-Oxidation in Coronary Heart Disease Patients with and without Type 2 Diabetes Mellitus</p> <p>Abstract</p> <p>Human serum albumin (HSA) has an important antioxidant activity due to the presence of the reduced cysteine at position 34, which represents the most abundant free thiol in the plasma. In oxidative-based diseases, HSA undergoes S-thiolation (THIO-HSA) with changes in the antioxidant function of albumin that could contribute to the progression of the disease. The aim of this study was to verify, for the first time, the different burdens of THIO-HSA, glycated HSA (GLY-HSA), and advanced glycation end products (AGE) accumulation both in type 2 diabetes mellitus (T2DM) patients and in non-diabetic patients, with or without coronary heart disease (CHD). In this study, we assessed the presence of modified forms of HSA, THIO-HSA, and GLY-HSA by means of mass spectrometry in 33 patients with both T2DM and CHD, in 31 patients with T2DM and without CHD, in 30 patients without diabetes with a history of CHD, and 27 subjects without diabetes and CHD. All the patients' anthropometric and clinical data were recorded including age, sex, duration of diabetes, body mass index (BMI), blood pressure, and history of CHD defined with anamnestic data. Metabolic parameters, such as fasting plasma glucose (FPG), glycated hemoglobin (HbA1c), lipids, pentosidine, AGE, receptor for advanced glycation end-products (RAGE) and its soluble form (sRAGE), were measured. AGE and pentosidine are significantly higher in T2DM patients with and without CHD with respect to non-diabetic patients with CHD and control subjects. RAGE levels are significantly higher in T2DM patients with respect to non-diabetic patients, and among T2DM patients, the group with CHD showed significantly higher RAGE levels than those without CHD (217 ± 171 pg/mL and 140 ± 61 pg/mL, respectively). Albumin isoforms discriminate between non-diabetic patients with CHD and T2DM patients with and without CHD and control subjects, with GLY-HSA levels higher in T2DM with and without CHD, and THIO-HSA higher in CHD patients without T2DM. Finally, we demonstrated that the oxidized forms of HSA can increase the expression of the inflammatory cytokine Tumor Necrosis Factor-alpha (TNFα) in monocytic cells. In patients with CHD, GLY-HSA and THIO-HSA have a different prevalent distribution, the first one prevailing in patients with T2DM and the second one in patients without T2DM. These findings suggest that albumin quality and homeostasis balance between glyco-oxidation and thiolation might have an impact on the antioxidant defense system in cardiovascular diseases.</p>
: Dataset related to the article "Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study"
<p>This record contains raw data related to the article “Circulating levels of AGEs and soluble RAGE isoforms are associated with all-cause mortality and development of cardiovascular complications in type 2 diabetes: a retrospective cohort study”.</p> <p><em><strong>Abstract</strong></em></p> <p><strong>Background: </strong>Advanced glycation end-products (AGEs) and their interaction with the receptor for advanced glycation end-products (RAGE) play a pivotal role in the development and progression of type 2 diabetes. In this retrospective cohort study, we explored the association of circulating levels of soluble RAGE (sRAGE) isoforms, i.e., endogenous secretory esRAGE and cleaved cRAGE, AGEs and their respective ratios with 15-year all-cause mortality in type 2 diabetes. <strong>Methods: </strong>Baseline AGEs and sRAGE isoforms concentration were measured by ELISA in 362 patients with type 2 diabetes and in 125 age- and gender-matched healthy control subjects (CTR). Independent predictors of mortality were determined using Cox proportional-hazards models and used to build and validate a nomogram for all-cause mortality prediction in type 2 diabetes. <strong>Results: </strong>AGEs, total sRAGE, cRAGE and the AGEs/sRAGE and AGEs/esRAGE ratios were significantly increased in patients with type 2 diabetes compared to CTR (p < 0.001). In CTR subjects, but not in type 2 diabetes patients, a significant negative correlation between cRAGE and age was confirmed (p = 0.003), whereas the AGEs/sRAGE (p = 0.032) and AGEs/cRAGE (p = 0.006) ratios were positively associated with age. At an average follow-up of 15 years (4,982 person-years), 130 deaths were observed. The increase in the AGEs/cRAGE ratio was accompanied by a higher risk of all-cause mortality in patients with type 2 diabetes (HR per each SD increment = 1.30, 95% CI 1.15-1.47; p < 0.001). Moreover, sRAGE was associated with the development of major adverse cardiovascular events (MACE) in type 2 diabetes patients without previous MACE (OR for each SD increase: 1.48, 95% CI 1.11-1.89). A nomogram based on age, sex, HbA1c, systolic blood pressure, and the AGEs/cRAGE ratio was built to predict 5-, 10- and 15-year survival in type 2 diabetes. Patients were categorized into quartiles of the monogram scores and Kaplan-Meier survival curves confirmed the prognostic accuracy of the model (log-rank p = 6.5 × 10<sup>- 13</sup>). <strong>Conclusions: </strong>The ratio between AGEs and the cRAGE isoform is predictive of 15-year survival in patients with type 2 diabetes. Our data support the assessment of circulating AGEs and soluble RAGE isoforms in patients with type 2 diabetes as predictors of MACE and all-cause mortality.</p> Enable Ginger<em>Cannot connect to Ginger</em> Check your internet connection<br> or reload the browserDisable in this text fieldRephraseRephrase current sentence<span class="ginger-floatingG-bar-tool-mistakes-count">26</span>Log in to edit with Ginger×
Duodenal Exclusion for the Treatment of Type 2 Diabetes
ClinicalTrials.gov study NCT00534547. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.