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1,315 results for “Aberrations”
Example plate with chromatic aberration pixel shift
<p>An example dataset of a full 384-well plate with 3 channels.<br> red and blue are aligned, green is somewhat misaligned.</p>
Data for: Breeding pairs with color aberrations in Oriental reed warblers
<p>One pair of Oriental red warblers was found with color aberrations. Two videos (ESM Video S1 and Video S2) were provided as supplementary material showing Breeding pairs with color aberrations in Oriental reed warblers. Our study shows that the breeding pair breed normally and further egg experiments indicated they can reject foreign eggs as other breeding pairs.</p>
Data from: Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
Using an ORF kinome screen in MCF-7 cells treated with the CDK4/6 inhibitor ribociclib plus fulvestrant, we identified FGFR1 as a mechanism of drug resistance. FGFR1-amplified/ER+ breast cancer cells and MCF-7 cells transduced with FGFR1 were resistant to fulvestrant ± ribociclib or palbociclib. This resistance was abrogated by treatment with the FGFR tyrosine kinase inhibitor (TKI) lucitanib. Addition of the FGFR TKI erdafitinib to palbociclib/fulvestrant induced complete responses of FGFR1-amplified/ER+ patient-derived-xenografts. Next generation sequencing of circulating tumor DNA (ctDNA) in 34 patients after progression on CDK4/6 inhibitors identified FGFR1/2 amplification or activating mutations in 14/34 (41%) post-progression specimens. Finally, ctDNA from patients enrolled in MONALEESA-2, the registration trial of ribociclib, showed that patients with FGFR1 amplification exhibited a shorter progression-free survival compared to patients with wild type FGFR1. Thus, we propose breast cancers with FGFR pathway alterations should be considered for trials using combinations of ER, CDK4/6 and FGFR antagonists.
A new remarkable cimicoid genus and species (Hemiptera, Heteroptera, Cimicomorpha) from mid-Cretaceous Burmese amber, with implications for its aberrant male genitalia
<p>Figure files of three different versions: published ver., without scale bars and captions ver., and the original figures.</p> <p> </p> <p>Original reference:</p> <p>Yamada, K., Yamamoto, S., Takahashi, Y. (2023) A new remarkable cimicoid genus and species (Hemiptera, Heteroptera, Cimicomorpha) from mid-Cretaceous Burmese amber, with implications for its aberrant male genitalia. <em><strong>Fossil Record</strong></em>, 26(1): 27–38. (doi: <a href="https://fr.pensoft.net/article/86784/">10.3897/fr.26.e86784</a>).</p> <p> </p> <p>Abstract.</p> <p>A new genus and species of cimicoid true bug, <em>Ecpaglocoris ditomeus</em> Yamada & Yamamoto, <strong>gen. et sp. nov.</strong>, is described and illustrated from mid-Cretaceous (Cenomanian–Albian) amber in the Kachin State of northern Myanmar (Burma). This new fossil genus and species is reminiscent of members of Anthocoridae by the strongly flattened and elongated body, four-segmented labium, distinct costal fracture and presence of fossula spongiosa on fore tibiae, but should not be ascribed to this family. The new taxon cannot be placed in any extant cimicoid families, based upon hemelytral, male genital and other morphological structures. Based on the hemelytral membrane venation and presence of dorsal laterotergites on abdominal segments I to VIII, it can be assumed that this new genus belongs to the extinct family Vetanthocoridae. <em>Ecpaglocoris ditomeus</em> <strong>gen. et sp. nov.</strong> has aberrant male genitalia characterised by sickle-shaped left and right parameres and grooves running throughout the paramere. This characteristic indicates that traumatic insemination occurred in this genus. The peculiar combination of male genital characteristics seen in <em>Ecpaglocoris</em> <strong>gen. nov.</strong> prevents its placement in any of the extant cimicoid families.</p>
Immediate Effects of Lipid-Based and Non-Lipid Artificial Tears on Corneal Aberrations
ClinicalTrials.gov study NCT06784661. IPD Sharing: NO. Countries: 1. Publications: 8.
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations
ClinicalTrials.gov study NCT03390504. IPD Sharing: Not stated. Countries: 27. Publications: 1.
Efficacy of Aripiprazole Versus Placebo in the Reduction of Aggressive and Aberrant Behavior in Autistic Children
ClinicalTrials.gov study NCT00468130. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Cequa Treatment on Accuracy of Pre-operative Biometry & Higher Order Aberrations in Dry Eye Patients Undergoing Cataract Surgery
ClinicalTrials.gov study NCT04342988. IPD Sharing: NO. Countries: 1. Publications: 2.
Data From: Contrasting physiological traits of shade tolerance in Pinus and Podocarpaceae native to a tropical Vietnamese forest: Insight from an aberrant flat-leaved pine
Open the record for dataset details and reuse information.
Data from: Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer
Open the record for dataset details and reuse information.
Data for: Breeding pairs with color aberrations in Oriental reed warblers
Open the record for dataset details and reuse information.
A genetic method to infer ploidy and aberrant inheritance in triploid organisms
Open the record for dataset details and reuse information.
Pan-cancer Aberrant Pathway Activity Analysis (PAPAA)
<p>Information about the dataset files:</p> <p>1) pancan_rnaseq_freeze.tsv.gz: Publicly available gene expression data for the TCGA Pan-cancer dataset. File: PanCanAtlas EBPlusPlusAdjustPANCAN_IlluminaHiSeq_RNASeqV2.geneExp.tsv was processed using script process_sample_freeze.py by Gregory Way et al as described in https://github.com/greenelab/pancancer/ data processing and initialization steps. [http://api.gdc.cancer.gov/data/3586c0da-64d0-4b74-a449-5ff4d9136611] [<a href="https://doi.org/10.1016/j.celrep.2018.03.046">https://doi.org/10.1016/j.celrep.2018.03.046</a>]</p> <p>2) pancan_mutation_freeze.tsv.gz: Publicly available Mutational information for TCGA Pan-cancer dataset. File: mc3.v0.2.8.PUBLIC.maf.gz was processed using script process_sample_freeze.py by Gregory Way et al as described in https://github.com/greenelab/pancancer/ data processing and initialization steps. [http://api.gdc.cancer.gov/data/1c8cfe5f-e52d-41ba-94da-f15ea1337efc] [https://doi.org/10.1016/j.celrep.2018.03.046] </p> <p>3) pancan_GISTIC_threshold.tsv.gz: Publicly available Gene- level copy number information of the TCGA Pan-cancer dataset. This file is processed using script process_copynumber.py by Gregory Way et al as described in https://github.com/greenelab/pancancer/ data processing and initialization steps. The files copy_number_loss_status.tsv.gz and copy_number_gain_status.tsv.gz generated from this data are used as inputs in our Galaxy pipeline. [https://xenabrowser.net/datapages/?cohort=TCGA%20Pan-Cancer%20(PANCAN)&removeHub=https%3A%2F%2Fxena.treehouse.gi.ucsc.edu%3A443] [<a href="https://doi.org/10.1016/j.celrep.2018.03.046">https://doi.org/10.1016/j.celrep.2018.03.046</a>]</p> <p>4) mutation_burden_freeze.tsv.gz: Publicly available Mutational information for TCGA Pan-cancer dataset mc3.v0.2.8.PUBLIC.maf.gz was processed using script process_sample_freeze.py by Gregory Way et al as described in https://github.com/greenelab/pancancer/ data processing and initialization steps. [https://github.com/greenelab/pancancer/][http://api.gdc.cancer.gov/data/1c8cfe5f-e52d-41ba-94da-f15ea1337efc] [https://doi.org/10.1016/j.celrep.2018.03.046]</p> <p>5) sample_freeze.tsv or sample_freeze_version4_modify.tsv: The file lists the frozen samples as determined by TCGA PanCancer Atlas consortium along with raw RNAseq and mutation data. These were previously determined and included for all downstream analysis All other datasets were processed and subset according to the frozen samples.[https://github.com/greenelab/pancancer/]</p> <p>6) cosmic_cancer_classification.tsv: Compendium of OG and TSG used for the analysis. Added additional genes from the cosmic database to volgelstein_cancer_classification.tsv [https://github.com/greenelab/pancancer/]</p> <p>7) CCLE_DepMap_18Q1_maf_20180207.txt.gz Publicly available Mutational data for CCLE cell lines from Broad Institute Cancer Cell Line Encyclopedia (CCLE) / DepMap Portal. [https://depmap.org/portal/download/api/download/external?file_name=ccle%2FCCLE_DepMap_18Q1_maf_20180207.txt]</p> <p>8) ccle_rnaseq_genes_rpkm_20180929_mod.tsv.gz: Publicly available Expression data for 1019 cell lines (RPKM) from Broad Institute Cancer Cell Line Encyclopedia (CCLE) / DepMap Portal. [https://depmap.org/portal/download/api/download/external?file_name=ccle%2Fccle_2019%2FCCLE_RNAseq_genes_rpkm_20180929.gct.gz]</p> <p>9) CCLE_MUT_CNA_AMP_DEL_binary_Revealer.tsv: Publicly available merged Mutational and copy number alterations that include gene amplifications and deletions for the CCLE cell lines. This data is represented in the binary format and provided by the Broad Institute Cancer Cell Line Encyclopedia (CCLE) / DepMap Portal. [https://data.broadinstitute.org/ccle_legacy_data/binary_calls_for_copy_number_and_mutation_data/CCLE_MUT_CNA_AMP_DEL_binary_Revealer.gct]</p> <p>10) GDSC_cell_lines_EXP_CCLE_names.tsv.gz Publicly available RMA normalized expression data for Genomics of Drug Sensitivity in Cancer(GDSC) cell-lines. File gdsc_cell_line_RMA_proc_basalExp.csv was downloaded. This data was subsetted to 389 cell lines that are common among CCLE and GDSC. All the GDSC cell line names were replaced with CCLE cell line names for further processing. [https://www.cancerrxgene.org/gdsc1000/GDSC1000_WebResources//Data/preprocessed/Cell_line_RMA_proc_basalExp.txt.zip]</p> <p>11) GDSC_CCLE_common_mut_cnv_binary.tsv.gz: A subset of merged Mutational and copy number alterations that include gene amplifications and deletions for common cell lines between GDSC and CCLE. This file is generated using CCLE_MUT_CNA_AMP_DEL_binary_Revealer.tsv and a list of common cell lines. </p> <p>12) gdsc1_ccle_pharm_fitted_dose_data.txt.gz: Pharmacological data for GDSC1 cell lines. [ftp://ftp.sanger.ac.uk/pub/project/cancerrxgene/releases/current_release/GDSC1_fitted_dose_response_15Oct19.xlsx]</p> <p>13) gdsc2_ccle_pharm_fitted_dose_data.txt.gz: Pharmacological data for GDSC2 cell lines. [ftp://ftp.sanger.ac.uk/pub/project/cancerrxgene/releases/current_release/GDSC2_fitted_dose_response_15Oct19.xlsx]</p> <p>14) compounds_of_interest.txt: list of pharmacological compounds tested for our analysis, taken from ftp://ftp.sanger.ac.uk/pub4/cancerrxgene/releases/release-8.1/screened_compounds_rel_8.1.csv. </p> <p>15) tcga_dictonary.tsv: list of cancer types used in the analysis. </p> <p>16) seg_based_scores.tsv: Measurement of total copy number burden, Percent of genome altered by copy number alterations. This file was used as part of the Pancancer analysis by Gregory Way et al as described in https://github.com/greenelab/pancancer/ data processing and initialization steps. [https://github.com/greenelab/pancancer/]</p> <p>17) GSE69822_pi3k_sign.txt: File with values assigned for tumor [1] or normal [-1] in given external samples (GSE69822)</p> <p>18) vlog_trans.csv: Variant stabilized log-transformed expression values in given external samples (GSE69822)</p> <p>19) path_rtk_ras_pi3k_genes.txt: File with the list of ERK/RAS/PI3K pathway genes used in the analysis. </p> <p>20) path_myc_genes.txt: File with the list of Myc pathway genes used in the analysis. (Sanchez-Vega, Francisco et al.)</p> <p>21) path_ras_genes.txt: File with the list of RAS pathway genes used in the analysis. (Sanchez-Vega, Francisco et al.)</p> <p>22) path_cell_cycle_genes.txt: File with the list of cell cycle pathway genes used in the analysis. (Sanchez-Vega, Francisco et al.)</p> <p>23) path_wnt_genes.txt: File with the list of WNT pathway genes used in the analysis. (Sanchez-Vega, Francisco et al.)</p> <p>24) GSE94937_rpkm_kras.csv: Expression values in given external samples (GSE94937)</p> <p>25) GSE94937_kras_sign.txt: File with values assigned for KRAS Mutant [1] or WT [-1] in given external samples (GSE94937)</p>
Supplementary Data for "Convergent organization of aberrant MYB complexes controls oncogenic gene expression in acute myeloid leukemia"
<p>These files contain the computational analysis of sequencing data and mass spectrometry data for "Convergent organization of aberrant MYB complexes controls oncogenic gene expression in acute myeloid leukemia" by Takao, Forbes, Uni, and Kentsis et al.</p>
FIGURE 23 in Review of the aberrant spider wasp genus Irenangelus Schulz (Pompilidae Ceropalinae) from the Indian subcontinent with the description of a new species
FIGURE 23. Distribution map of Irenangelus species occurring in the Indian subcontinent (with extralimital I. pernix (Bingham)).
FIGURES 15–22. Irenangelus punctipleuris Wahis, 2007 in Review of the aberrant spider wasp genus Irenangelus Schulz (Pompilidae Ceropalinae) from the Indian subcontinent with the description of a new species
FIGURES 15–22. Irenangelus punctipleuris Wahis, 2007. ♀. 15. Habitus, lateral view; 16. Habitus, dorsal view; 17. Head, frontal view; 18. Antenna; 19. Head and mesosoma, dorsal view; 20. Head and mesosoma, lateral view; 21. Fore wing and hind wing; 22. Metasoma, lateral view. Scale bar: Figs 15, 16– 5 mm; Figs 17, 18, 19– 1 mm; Figs 20, 21, 22– 2 mm.
FIGURES 9–12 in Review of the aberrant spider wasp genus Irenangelus Schulz (Pompilidae Ceropalinae) from the Indian subcontinent with the description of a new species
FIGURES 9–12. Irenangelus acuminatus Binoy & Girish Kumar, sp. nov. Holotype, ♂. 9. Head and mesosoma, lateral view; 10. Fore wing and hind wing; 11. Metasoma, lateral view; 12. Gastral sternites and hypopygium, ventral view.. Scale bar: Figs 9, 10, 11–500 µm; Fig. 12– 200 µm.
FIGURES 13–14. Irenangelus punctipleuris Wahis, 2007 in Review of the aberrant spider wasp genus Irenangelus Schulz (Pompilidae Ceropalinae) from the Indian subcontinent with the description of a new species
FIGURES 13–14. Irenangelus punctipleuris Wahis, 2007. Holotype, ♀. 13. Habitus, lateral view; 15. Data on label with part of fore wing.
FIGURES 1–8 in Review of the aberrant spider wasp genus Irenangelus Schulz (Pompilidae Ceropalinae) from the Indian subcontinent with the description of a new species
FIGURES 1–8. Irenangelus acuminatus Binoy & Girish Kumar, sp. nov. Holotype, ♂. 1. Habitus, lateral view; 2. Habitus, dorsal view; 3. Head and antenna, lateral view; 4. Head, dorsal view; 5. Head, frontal view; 6. Clypeus in part and labrum; 7. Mesosoma, dorsal view; 8. Scutellum, metanotum, metapostnotum, and propodeum, dorsal view. Scale bar: Figs 1, 2– 2 mm; Figs 3, 5, 7– 500 µm; Figs 4, 8– 200 µm; Fig. 6– 100 µm.
FIGURES 31–37 in Chimaerocyon gen. nov., a morphologically aberrant myrmecophilous genus of water scavenger beetle (Coleoptera: Hydrophilidae: Sphaeridiinae)
FIGURES 31–37. Phylogenetic position of Chimaerocyon. 31—Bayesian tree based on four genes concatenated (branches with posterior probability values). 32—mapping of relevant tribal-level characters on the tree (full circle = gain, crossed circle = loss). 33–37—diagnostic tribal-level characters illustrated on selected representatives of the Sphaeridiinae. Abbreviations (numbers refer to characters in Fig. 32): angr—antennal groove, comcl—compact antennal club, curt—curved metatibia, elpr—elevated median portion of prosternum, excly—excised lateral portion of clypeus (exposed antennal bases), llob—lateral lobes of clypeus, msuc—male sucker on maxilla, pgr—grooves for reception of procoxae, pros—well-developed prosternum, wepi—wide epipleuron posteriorly.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.