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Text-fig. 5. Platanaceae 1–3. Macginitiea nobilis (NEWBERRY) comb. nov. 1. This specimen is labeled as corresponding to Newberry 1898, pl. 50, fig. 1 although it does not match the published drawing exactly. From near Fort Clark, North Dakota, USNM 6964. 2. Lectotype from Newberry (1898, pl. 34), from near Fort Clark, North Dakota; composite picture assembled from images of both counterparts. USNM 1070. 3. Trilobed leaf from Seven Mile Creek, Montana (orig. figured as Platanus nobilis NEWBERRY by Ward 1886, pl. 41, fig. 1). USNM 4093. 4. Platananthus speirsae PIGG et STOCKEY axis with at least 9 attached pedunculate staminate inflorescences (arrows), Seven Mile Creek, Montana (orig. Ward 1885b, pl. 32, fig. 7), USNM 4225. Scale bars 5 cm. in Revisions To Roland Brown'S North American Paleocene Flora
Text-fig. 5. Platanaceae 1–3. Macginitiea nobilis (NEWBERRY) comb. nov. 1. This specimen is labeled as corresponding to Newberry 1898, pl. 50, fig. 1 although it does not match the published drawing exactly. From near Fort Clark, North Dakota, USNM 6964. 2. Lectotype from Newberry (1898, pl. 34), from near Fort Clark, North Dakota; composite picture assembled from images of both counterparts. USNM 1070. 3. Trilobed leaf from Seven Mile Creek, Montana (orig. figured as Platanus nobilis NEWBERRY by Ward 1886, pl. 41, fig. 1). USNM 4093. 4. Platananthus speirsae PIGG et STOCKEY axis with at least 9 attached pedunculate staminate inflorescences (arrows), Seven Mile Creek, Montana (orig. Ward 1885b, pl. 32, fig. 7), USNM 4225. Scale bars 5 cm.
Text-fig. 7. Cercidiphyllaceae 1–3. Trochodendroides genetrix (NEWBERRY) comb. nov. and associated reproductive structures (4, 5) from Killpecker Cr., Rock Springs, Wyoming (UF loc. 18126). 1. Twig with three attached leaves, showing variation in leaf shape and serration; composite figure assembled from images of both counterparts, UF 35427. 2. Complete leaf including petiole, UF 13243. 3. Same as 2, detail of venation. 4. Nyssidium arcticum (HEER) ILJINSKAYA fruits on an incomplete axis, UF 35454. 5. Dispersed winged seed, UF 35479. Scale = 3 cm in 1, 2; 1 cm in 3, 4; 0.5 cm in 5. in Revisions To Roland Brown'S North American Paleocene Flora
Text-fig. 7. Cercidiphyllaceae 1–3. Trochodendroides genetrix (NEWBERRY) comb. nov. and associated reproductive structures (4, 5) from Killpecker Cr., Rock Springs, Wyoming (UF loc. 18126). 1. Twig with three attached leaves, showing variation in leaf shape and serration; composite figure assembled from images of both counterparts, UF 35427. 2. Complete leaf including petiole, UF 13243. 3. Same as 2, detail of venation. 4. Nyssidium arcticum (HEER) ILJINSKAYA fruits on an incomplete axis, UF 35454. 5. Dispersed winged seed, UF 35479. Scale = 3 cm in 1, 2; 1 cm in 3, 4; 0.5 cm in 5.
Figure. Constrained ordination plot as produced from canonical correspondence analysis (CCA). The variability of environmental variables is summarized on Axis 1 and Axis 2 of the constrained biplot, explaining the variability of the trophic groups included in the red fox's diet. Trophic groups are shown with black line (unfilled) pyramids, whereas environmental variables are shown with black filled pyramids. Proximity and distance of response centroids to predictor centroids indicate positive and negative correlations between them, respectively. in Factors affecting the diet of the red fox (Vulpes vulpes) in a heterogeneous Mediterranean landscape
Figure. Constrained ordination plot as produced from canonical correspondence analysis (CCA). The variability of environmental variables is summarized on Axis 1 and Axis 2 of the constrained biplot, explaining the variability of the trophic groups included in the red fox's diet. Trophic groups are shown with black line (unfilled) pyramids, whereas environmental variables are shown with black filled pyramids. Proximity and distance of response centroids to predictor centroids indicate positive and negative correlations between them, respectively.
Fig. 7 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 7. Photograph (A) and outline drawing (B) of the axis of BP/1/5678, a putative specimen of Elliotsmithia longiceps Broom, 1937, Tapinocephalus Assemblage Zone, Abrahamskraal Formation, Middle Permian, Western Cape Province, South Africa (Modesto et al. 2001) or Heleosaurus scholtzi Broom, 1907, Tapinocephalus Assemblage Zone, Abrahamskraal Formation, Middle Permian (Botha−Brink and Modesto 2009).
Fig. 6 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 6. Bivariate plots and regression analyses of the atlas−axis complex in varanopids and other non−therapsid synapsids. A. Spine height relative to centrum height. B. Spine length relative to centrum height. C. Residual plot of spine height. D. Residual plot of spine length. The regressions results and statistics are presented in the table below A and B.
Fig. 5 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 5. Atlas−axis complexes of varanopid outgroups used in recent phylogenetic analyses (Botha−Brink and Modesto 2009; Campione and Reisz 2010). A. Atlas−axis complex of Archaeovenator hamiltonensis Reisz and Dilkes, 2003, Virgilian Series, Upper Pennsylvanian, Hamilton Quarry, Greenwood County, Kansas (modified from Reisz and Dilkes 2003). B. Cotylorhynchus romeri Stovall, 1937, Hennessey Formation, Permian, Logan County, Oklahoma (after Stovall et al. 1966). C. Ophiacodon retroversus Romer and Price, 1940, Admiral Formation, Wichita Group, Lower Permian, Wichita County, Texas (after Romer and Price 1940).
Fig. 4 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 4. Axis of an indeterminate mycterosaurine from Richards Spur, Oklahoma, USA, Lower Permian, OMNH 53514, identical to the undescribed mycterosaurine skull, OMNH 73500. This specimen has an anteroposteriorly elongate spine and a flat dorsal margin in lateral view. Specimen in right lateral (A) anterior (B), dorsal (C), left lateral (D), posterior (E), and ventral (F) views.
Fig. 1 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 1. Outline reconstructions of the skull of varanopids. A. Mesenosaurus romeri Efremov, 1938 (modified from Reisz and Berman 2001). B. Varanodon agilis Olson, 1965 (modified from Reisz and Laurin 2004). These taxa show the characteristic differences in the occiput of varanopids. Not to scale.
Fig. 2 in Morphology and evolutionary significance of the atlas-axis complex in varanopid synapsids
Fig. 2. Atlas−axis complex of varanodontines. A. Aerosaurus wellesi Langston and Reisz, 1981, Abo/Cutler Formation, Cutler Group, Upper Pennsylvanian–Lower Permian; El Cobre Canyon, Rio Arriba County, New Mexico, UCMP 40096, in right lateral view, drawing (A1) and reconstruction (A2). B. Varanodon agilis Olson, 1965, Chickasha Formation, Permian, Blaine County, Oklahoma, FMNH UR 986 in left lateral view, drawing (B1) and reconstruction (B2). C. Varanops brevirostris (Williston, 1911), Arroyo Formation, Clear Fork Group, Lower Permian; Indian Creek, Baylor County, Texas, FMNH UR 2423, drawing in left lateral view (C1), reconstruction in ventral view (C2), and reconstruction in left lateral view (C3).
Fig. 13. Axis complex and cervical vertebrae 3–4 in Osteology and relationships of Olorotitan arharensis, a hollow-crested hadrosaurid dinosaur from the latest Cretaceous of Far Eastern Russia
Fig. 13. Axis complex and cervical vertebrae 3–4 of hadrosaurid dinosaur Olorotitan arharensis Godefroit, Bolotsky, and Alifanov 2003 (AEHM 2/845, holotype), from the Upper Cretaceous of Kundur (Russia), in right lateral (A) and dorsal (B) views. Abbreviatons: ax, axis; cv, cervical vertebra.
A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin-1 axis
<p><span>Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. The majority of <a>patients p</a></span><span>resent with early-stage disease, but a substantial proportion progress to myelofibrosis and/or secondary leukemia, advanced cancers with a poor prognosis and high symptom burden. Currently, it remains difficult to predict progression, and therapies that reliably prevent or reverse fibrosis are lacking. A major bottleneck to the discovery of disease-modifying therapies has been an incomplete understanding of the interplay between perturbed cellular and molecular states. </span><span>Several cell types have individually been implicated, but a comprehensive analysis of myelofibrotic bone marrow is lacking. We therefore mapped the crosstalk between bone marrow cell types in myelofibrotic bone marrow. We found that inflammation and fibrosis are orchestrated by a ‘quartet’ of immune and stromal cell lineages – with basophils and mast cells creating a TNF signaling hub, communicating with megakaryocytes, mesenchymal stromal cells and pro-inflammatory fibroblasts. We identified the </span><span>b</span><span>-galactoside binding protein galectin-1 as a striking biomarker of progression to myelofibrosis and poor survival in multiple patient cohorts, and as a promising therapeutic target, with reduced myeloproliferation and fibrosis </span><a><span>in vitro</span></a><span> and </span><span>in vivo </span><span>and improved survival following galectin-1 inhibition. In human bone marrow organoids, TNF increased galectin-1 expression, suggesting a feedback loop wherein the pro-inflammatory MPN clone creates a self-reinforcing niche, fueling progression to advanced disease. This study pr</span><span>ovides a valuable resource for studying hematopoietic cell-niche interactions, with broad relevance for cancer-associated inflammation and disorders of tissue fibrosis. </span></p>
Figure 15. Cletocamptus axi Mielke, 2000 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 15. Cletocamptus axi Mielke, 2000. (A) Female anal somite and caudal rami, dorsal; (B) male P1. Scale bar: 75 Mm.
Figure 13. Cletocamptus axi Mielke, 2000 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 13. Cletocamptus axi Mielke, 2000. Male. (A) Anal somite and caudal rami, dorsal; (B) urosome, ventral (P5-bearing somite omitted); (C) urosome, dorsal (P5-bearing somite omitted). Scale bar: 100 Mm (A); 240 Mm (B, C).
Figure 14. Cletocamptus axi Mielke, 2000 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 14. Cletocamptus axi Mielke, 2000. Female. (A) P6; (B) anal somite and caudal rami, dorsal; (C) anal operculum; (D) left caudal ramus, dorsal; (E) P1; (F) aberrant P3 ENP. Scale bar: 100 Mm (A); 200 Mm (B); 70 Mm (C); 100 Mm (D); 117 Mm (E); 115 Mm (F).
Figure 10 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 10. Cletocamptus cecsurirensis sp. nov. Male. (A) P1; (B) dimorphic inner projection of basis of P1; (C) P2. Scale bar: 100 Mm (A); 143 Mm (B); 100 Mm (C).
Figure 11 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 11. Cletocamptus cecsurirensis sp. nov. Male. (A) P3; (B) endopod of P3; (C) P4. Scale bar: 100 Mm (A); 143 Mm (B); 100 Mm (C).
Figure 4 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 4. Cletocamptus cecsurirensis sp. nov. Female. (A) Antenna; (B) antennal exopod; (C) distal part of antennal endopod; (D) mandible; (E) maxillule; (F) maxilla. Scale bar: 86 Mm (A); 51 Mm (B–F).
Figure 9 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 9. Cletocamptus cecsurirensis sp. nov. Male. (A) Rostrum, and first and second antennular segments; (B) antennule; (C) last antennular segment; (D) P5. Scale bar: 100 Mm (A, B); 143 Mm (C); 100 Mm (D).
Figure 1 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 1. Cletocamptus cecsurirensis sp. nov. Female. (A) Habitus, dorsal; (B) habitus, lateral. Scale bar: 427 Mm.
Figure 8 in A new species of Cletocamptus (Copepoda: Harpacticoida) from Chile and some notes on Cletocamptus axi Mielke, 2000
Figure 8. Cletocamptus cecsurirensis sp. nov. Male. (A) Urosome, dorsal (P5-bearing somite omitted); (B) urosome, ventral (P5-bearing somite omitted). Scale bar: 100 Mm.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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