Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
606
datasets available to search
ShareScore release 0.7.1
Dataset results
606 results for “Bioactivation”
Data from: Identification of anti-fungal bioactive terpenoids from the bioenergy crop switchgrass (Panicum virgatum)
<p>Plant derived bioactive small molecules have attracted attention of scientists across fundamental and applied scientific disciplines. We seek to understand the influence of these phytochemicals on functional phytobiomes. Increased knowledge of specialized metabolite bioactivities could inform strategies for sustainable crop production. We hypothesized that – consistent with accumulating evidence that switchgrass genotype impacts microbiome assembly – differential terpenoid accumulation contributes to switchgrass ecotype-specific microbiome composition. An initial in vitro plate-based disc diffusion screen of 18 switchgrass root derived fungal isolates revealed differential responses to upland- and lowland-isolated metabolites. To identify specific fungal growth-modulating metabolites, we tested fractions from root extracts on three ecologically important fungal isolates – <em>Linnemania elongata</em>, <em>Trichoderma</em> sp. and <em>Fusarium</em> sp. Saponins and diterpenoids were identified as the most prominent antifungal metabolites. Finally, analysis of liquid chromatography-purified terpenoids revealed fungal inhibition structure – activity relationships (SAR). Saponin antifungal activity was primarily determined by the number of sugar moieties – saponins glycosylated at a single core position were inhibitory whereas saponins glycosylated at two core positions were inactive. Saponin core hydroxylation and acetylation were also associated with reduced activity. Diterpenoid activity required the presence of an intact furan ring for strong fungal growth inhibition.</p>
Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components
ClinicalTrials.gov study NCT05318183. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intranasal Inhalations of Bioactive Factors Produced by M2 Macrophages in Patients With Organic Brain Syndrome
ClinicalTrials.gov study NCT02957123. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety and Potential Bioactivity of CLBS16 in Patients With Coronary Microvascular Dysfunction and Without Obstructive Coronary Artery Disease
ClinicalTrials.gov study NCT03508609. IPD Sharing: NO. Countries: 1. Publications: 2.
Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans
ClinicalTrials.gov study NCT03194620. IPD Sharing: YES. Countries: 1. Publications: 7.
Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction
ClinicalTrials.gov study NCT01878084. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Safety and Bioactivity of Ipilimumab and Nivolumab Combination Prior to Liver Resection in Hepatocellular Carcinoma
ClinicalTrials.gov study NCT03682276. IPD Sharing: NO. Countries: 1. Publications: 1.
Effectiveness of Bioactive Resin Varnish and Fluoride Containing Xylitol Varnish in Management of Teeth Hypersensitivity
ClinicalTrials.gov study NCT04568473. IPD Sharing: NO. Countries: 1. Publications: 1.
Umbrella review data of colour-associated bioactive pigments found in fruit and vegetables, compared to placebo or low intakes, on human health outcomes relevant to public health
Open the record for dataset details and reuse information.
Reduction and modification of graphene derivatives with bioactive compounds
Open the record for dataset details and reuse information.
An advancement in developmental and reproductive toxicity (DART) risk assessment: evaluation of a bioactivity and exposure-based NAM toolbox
Open the record for dataset details and reuse information.
Data from: Identification of anti-fungal bioactive terpenoids from the bioenergy crop switchgrass (Panicum virgatum)
Open the record for dataset details and reuse information.
Data from: Long read reference genome-free reconstruction of a full-length transcriptome from Astragalus membranaceus reveals transcript variants involved in bioactive compound biosynthesis
Astragalus membranaceus, also known as Huangqi in China, is one of the most widely used medicinal herbs in Traditional Chinese Medicine. Traditional Chinese Medicine formulations from Astragalus membranaceus have been used to treat a wide range of illnesses, such as cardiovascular disease, type 2 diabetes, nephritis and cancers. Pharmacological studies have shown that immunomodulating, anti-hyperglycemic, anti-inflammatory, antioxidant and antiviral activities exist in the extract of Astragalus membranaceus. Therefore, characterising the biosynthesis of bioactive compounds in Astragalus membranaceus, such as Astragalosides, Calycosin and Calycosin-7-O-β-D-glucoside, is of particular importance for further genetic studies of Astragalus membranaceus. In this study, we reconstructed the Astragalus membranaceus full-length transcriptomes from leaf and root tissues using PacBio Iso-Seq long reads. We identified 27 975 and 22 343 full-length unique transcript models in each tissue respectively. Compared with previous studies that used short read sequencing, our reconstructed transcripts are longer, and are more likely to be full-length and include numerous transcript variants. Moreover, we also re-characterised and identified potential transcript variants of genes involved in Astragalosides, Calycosin and Calycosin-7-O-β-D-glucoside biosynthesis. In conclusion, our study provides a practical pipeline to characterise the full-length transcriptome for species without a reference genome and a useful genomic resource for exploring the biosynthesis of active compounds in Astragalus membranaceus.
Anticancer bioactive peptide combined with oxaliplatin against gastric cancer by regulation of PI3K/AKT signaling via inhibition of TPX2
Open the record for dataset details and reuse information.
Machine Learning Tools for Peptide Bioactivity Evaluation Implications for Cell Culture Media Optimization and the Broader Cultivated Meat Industry
Open the record for dataset details and reuse information.
Towards the Use of Lichens as a Source of Bioactive Substances for Topical Applications
Open the record for dataset details and reuse information.
Bioactive compounds, antioxidant activity, and sensory profile of sorghum tisane
<p>This dataset provides the result of bioactive compounds, antioxidant activity, sensory acceptance, and sensory profile measurements towards sorghum tisane with different pericarp colors.</p>
Bioactive Catalytic Nanocompartments Integrated into Cell Physiology and Their Amplification of a Native Signaling Cascade
<p>Data underlying the figures in the publication “Bioactive Catalytic Nanocompartments Integrated into Cell Physiology and Their Amplification of a Native Signaling Cascade”, published in <em>ACS Nano,</em> <strong>2020</strong>, 14, 9, 12101–12112.</p> <p><a href="https://pubs.acs.org/doi/10.1021/acsnano.0c05574">https://pubs.acs.org/doi/10.1021/acsnano.0c05574</a></p> <p>Table of contents:</p> <p><strong>1. Figure 1</strong>; Zip file containing the TEM micrographs, and numerical data for <em>Figure 1</em>.</p> <p><strong>2. Figure 2</strong>; Zip file containing the numerical data for the activity studies of <em>Figure 2</em>.</p> <p><strong>3. Figure 3</strong>; Zip file containing the numerical data for the activity studies of <em>Figure 3</em>.</p> <p><strong>4. Figure 4</strong>; Zip file containing the numerical data for <em>Figure 4</em>.</p> <p><strong>5. Figure 6</strong>; Zip file containing the numerical data for <em>Figure 6</em>.</p> <p> </p>
Characterisation and Bioactivity Analysis of Peridinin-Chlorophyll a-Protein (PCP) Isolated form Symbiodinium tridacnidorum CS-73
<p>Peridinin-Chlorophyll <em>a</em>-Proteins (PCPs) are the major light harvesting proteins in photosynthetic dinoflagellates. PCP shows great variation in protein length, pigment ratio, sequence and spectroscopic properties. PCP conjugates (PerCP) are widely used as fluorescent-probes for cellular and tissue analysis in the biomedical field. PCP consists of a peridinin carotenoid, thereby it can potentially be used as a bioactive compound in pharmaceutical applications. However, biological activities of PCPs are yet to be explored. In this study, we extracted, purified and partially characterised the PCP from<em> Symbiodinium tridacnidorum </em>(CS-73) and explored its antioxidant, anti-cancer and anti-inflammation bioactivities. The PCP was purified using an ÄKTA™ PURE system and predicted to be of 17.3 kDa molecular weight (confirmed as a single band on SDS-PAGE) with an isoelectric point (pI) 5.6. LC-MS/MS and bioinformatic analysis of purified PCP digested with trypsin indicated it was 164 amino acids long with >90% sequence similarity to PCP of SymA3.s6014_g3 (belonging to clade A of <em>Symbiodinium </em>sp.) confirmed with 59 peptide combinations matched across its protein sequence. The spectroscopic properties of purified PCP showed a slight shift in absorption and emission spectra to previously documented analysis in <em>Symbiodinium</em> species. Purified PCP consisted of a 19 amino acid long signal peptide at its N terminal and 9 helixes in its secondary structure with several protein binding sites and no DNA/RNA binding sites. Further, purified PCP at a concentration of 0.1 - 0.8 mg/mL exhibited moderate to high antioxidant, anti-cancer and anti-inflammation bioactivities against tumor macrophage (RAW 264.7), human metastatic breast adenocarcinoma (MDA-MB-231) and human colorectal (HTC-15) cancer cell lines. Together, all these findings present PCP as a promising candidate for continued investigations for pharmaceutical applications to cure chronic diseases, apart from its existing application as a fluorescent-probe.</p>
Statistics "Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis"
<p>Details to the statistics for the "Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis"</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.