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143 results for “Btk”
Figure 9 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 9 Metaphire posthuma (Vaillant, 1868) A Male region, ventral view B spermathecal region, ventral view C right spermatheca D left prostatic gland E intestinal caecum. Scale bar: 1mm.
Figure 7 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 7 Metaphire peguana (Rosa, 1890) A Male region, ventral view B spermathecal region, ventral view C left spermathecae D left prostatic gland E intestinal caecum. Scale bar: 1mm.
Figure 6 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 6 Metaphire houlleti (Perrier, 1872) A Male region, ventral view B spermathecal region, lateral view C left spermatheca D left prostatic gland E intestinal caecum. Scale bar: 1mm.
Figure 5 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 5 Metaphire doiphamon Bantaowong & Panha, 2016 A1, A2, A3 Male region (concave form – A2 and convex form – A3) ventral view B1, B2 left spermatheca C spermathecal region, ventral view D1, D2 right prostatic gland E testis sacs and vessciles F1, F2 intestinal caecum G transection via male porophore H transection via genital markings. Scale bar: 1mm.
Figure 4 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 4 Metaphire californica (Kinberg, 1867) A Male region, ventral view B right spermatheca C right prostatic gland D spermathecal region E intestinal caecum F transection via copulatory pouch. Scale bar: 1mm.
Figure 11 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 11 Amynthas catenatus sp. nov. Holotype CTU–EW.184.h01 A1, A2 Male region, ventral view B1, B2 left prostatic gland C spermathecal region, ventral view D1, D2 left spermathecae D testis sacs and vesicles F1, F2 intestinal caecum G transection via male porophore H transection via genital marking. Scale bar: 1mm.
Figure 2 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 2 Lampito mauritii Kinberg, 1867 A Clitellum, ventral view B spermathecal region, ventral view C left spermatheca D Prostatic glands. Scale bar: 1mm.
Figure 13 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 13 A. phuquocsensis sp. nov. Holotype (CTU–EW.190.h01) A1, A2 Male region, ventral view B1, B2 right spermathecae C1, C2 spermathecal region, ventral view D testis sacs and vesicles E intestinal caecum F1, F2 right prostatic gland G transection via male porophore H transection via genital marking. Scale bar: 1mm.
Figure 3 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 3 Metaphire bahli (Gates, 1945) A Male region, ventral view B spermathecal region, ventral view C left spermatheca D right prostatic gland E intestinal caecum; Scale bar: 1mm.
Figure 14 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 14 Amynthas poropapillatus sp. nov. Holotype (CTU–EW.190.h01) A1, A2 male region, ventral view B1, B2 right prostatic gland C1, C2 spermathecal region, ventral view D testis sacs and vesicles E intestinal caecum F1, F2 right spermathecae G male pore, ventral view H longitudinal transection via male porophore I transverse transection via male porophore. Scale bar: 1mm.
Figure 10 from: Nguyen TT, Lam DH, Trinh BTK, Nguyen AD (2020) The megascolecid earthworms (Annelida, Oligochaeta, Megascolecidae) in the Phu Quoc island, Vietnam, with descriptions of three new species. ZooKeys 932: 1-25. https://doi.org/10.3897/zookeys.932.50314
Figure 10 Metaphire dorsobitheca (Thai et Huynh, 1992) (CTU–EW.191.h01) A1, A2 Male region, ventral view B1, B2 right spermathecae C spermathecal region, dorsal view D1, D2 intestinal caecum E Testis sacs and vesicles F1, F2 left prostatic gland G transection via copulatory pouch. Scale bar: 1mm.
Data from: Inhibition of BTK and ITK with ibrutinib is effective in the prevention of chronic graft-versus-host disease in mice
Bruton's Tyrosine Kinase (BTK) and IL-2 Inducible T-cell Kinase (ITK) are enzymes responsible for the phosphorylation and activation of downstream effectors in the B-cell receptor (BCR) signaling and T cell receptor (TCR) signaling pathways, respectively. Ibrutinib is an FDA-approved potent inhibitor of both BTK and ITK that impairs B-cell and T-cell function. CD4 T cells and B cells are essential for the induction of chronic graft-versus-host disease (cGVHD). We evaluated these targets by testing the ability of Ibrutinib to prevent or ameliorate cGVHD, which is one of the major complications for patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). We found that Ibrutinib significantly alleviated cGVHD across four different mouse models, accompanied by increased long-term survival and reduced clinical score. The clinical improvements in Ibrutinib-treated recipients were associated with decreased serum-autoantibodies, costimulatory molecule activation, B-cell proliferation, and glomerulonephritis compared to vehicle controls. Ibrutinib was also able to alleviate the clinical manifestations in acute GVHD (aGVHD), where the recipients were given grafts with or without B cells, suggesting that an inhibitory effect of Ibrutinib on T cells contributes to a reduction in both aGVHD and cGVHD pathogenesis. An effective prophylactic regimen is still lacking to both reduce the incidence and severity of human cGVHD following allo-HSCT. Our study shows that Ibrutinib is an effective prophylaxis against several mouse models of cGVHD with minimal toxicity and could be a promising strategy to combat human cGVHD clinically.
Belgian-Italian Trial to Evaluate the Efficacy and Safety of Below The Knee (BTK) Treatment With the Luminor 14 Paclitaxel Coated Percutaneous Transluminal Angioplasty Balloon Catheter of iVascular
ClinicalTrials.gov study NCT03845543. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Lutonix DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries
ClinicalTrials.gov study NCT01870401. IPD Sharing: Not stated. Countries: 8. Publications: 0.
LIFE-BTK PK Sub-study
ClinicalTrials.gov study NCT05208905. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Acalabrutinib (ACP-196), a Btk Inhibitor, for Treatment of de Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT02112526. IPD Sharing: YES. Countries: 2. Publications: 0.
A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cel
ClinicalTrials.gov study NCT06846671. IPD Sharing: YES. Countries: 12. Publications: 0.
A Study of INCB050465 in Relapsed or Refractory Mantle Cell Lymphoma Previously Treated With or Without a Bruton's Tyrosine Kinase (BTK) Inhibitor
ClinicalTrials.gov study NCT03235544. IPD Sharing: YES. Countries: 11. Publications: 0.
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)
ClinicalTrials.gov study NCT04458051. IPD Sharing: YES. Countries: 42. Publications: 0.
Serologic Response to SHINGRIX Vaccine in Patients With CLL and WM Treated With BTK Inhibitors
ClinicalTrials.gov study NCT03771157. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.