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438 results for “Caenorhabditis elegans”
Data from: The Red Death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans
Understanding the genetic basis of susceptibility to pathogens is an important goal of medicine and of evolutionary biology. A key first step toward understanding the genetics and evolution of any phenotypic trait is characterizing the role of mutation. However, the rate at which mutation introduces genetic variance for pathogen susceptibility in any organism is essentially unknown. Here we quantify the per-generation input of genetic variance by mutation (VM) for susceptibility of Caenorhabditis elegans to the pathogenic bacterium Pseudomonas aeruginosa (defined as the median time of death, LT50). VM for LT50 is slightly less than VM for a variety of life-history and morphological traits in this strain of C. elegans, but is well within the range of reported values in a variety of organisms. Mean LT50 did not change significantly over 250 generations of mutation accumulation. Comparison of VM to the standing genetic variance (VG) implies a strength of selection against new mutations of a few tenths of a percent. These results suggest that the substantial standing genetic variation for susceptibility of C. elegans to P. aeruginosa can be explained by polygenic mutation coupled with purifying selection.
FIGURE 3 in Comparison of the cryptic nematode species Caenorhabditis brenneri sp. n. and C. remanei (Nematoda: Rhabditidae) with the stem species pattern of the Caenorhabditis Elegans group
FIGURE 3. Caenorhabditis brenneri sp. n. male. A: posterior end ventral showing bursa, spicules, gubernaculum; note the striped pattern of the cuticle in the posterior part of the tail; B: posterior end lateral; C: spicules and gubernaculum subventral; arrow points to the conspicuous lateral projections on the gubernaculum ("ears"); D: series demonstrating the bending of the gubernaculum when the spicules are extruded, lateral view, also showing the hook; E–F: aberrant right (E) and normal left spicule (F) of the same specimen lateral; G–I: aberrant positions of genital papillae: both GP1 positioned anterior of the bursa (G, H), right GP1shifted to the anterior margin of the bursa (I).
FIGURE 2 in Comparison of the cryptic nematode species Caenorhabditis brenneri sp. n. and C. remanei (Nematoda: Rhabditidae) with the stem species pattern of the Caenorhabditis Elegans group
FIGURE 2. Caenorhabditis brenneri sp. n. female. A: anterior end subventral, with anterior end of lateral canal; B: anterior end ventral; C: pharynx region with lateral field and deirid; D: secretory-excretory system at the level of the deirid ventral; E: anus region lateral, with posterior end of lateral canal and phasmid.
FIGURE 1 in Comparison of the cryptic nematode species Caenorhabditis brenneri sp. n. and C. remanei (Nematoda: Rhabditidae) with the stem species pattern of the Caenorhabditis Elegans group
FIGURE 1. Distribution map for three Caenorhabditis species. Records from west to east: for C. brenneri sp. n. (circles): Costa Rica, Trinidad, Guadeloupe, (? Bukawu), Bangalore, Penang, Sumatra, Bali; for C. remanei (squares) North America (Washington, Ohio, Indiana, New York, Connecticut, Massachusetts), Europe (North-France, Switzerland, Germany, Hungary), East Asia (Shanghai, Kyushu, Honshu); for the recently discovered gonochoristic C. sp. n. 5 in China (triangles): Sanjiang, Guangxi Province (JU727); Guangzhou, Guangdong Province (SB378). Details in text.
FIGURE 5 in Comparison of the cryptic nematode species Caenorhabditis brenneri sp. n. and C. remanei (Nematoda: Rhabditidae) with the stem species pattern of the Caenorhabditis Elegans group
FIGURE 5. Phylogenetic tree (after Kiontke & Sudhaus 2006) and geographic distribution of the Elegans group and related species. With the exception of C. craspedocerca (Völk) and C. perrieri (Maupas), all species were found in Asia. Species highlighted in red are so far only known from Asia. *C. clavopapillata (Kreis & Faust) was isolated from captive dogs and monkeys in the USA. Its natural range is unknown.
FIGURE 4 in Comparison of the cryptic nematode species Caenorhabditis brenneri sp. n. and C. remanei (Nematoda: Rhabditidae) with the stem species pattern of the Caenorhabditis Elegans group
FIGURE 4. Aspects of male copulatory structures in C. brenneri sp. n. (A–D) and C. remanei (E–G). A and E: bursa in ventral view showing precloacal hook, distal part of gubernaculum and genital papillae (GP). In A the GPs are numbered (v = ventral GPs, ad = anterior dorsal GP, pd = posterior dorsal GP slightly out of focus). The differences in size and shape of the bursa in A and E are individual differences and do not mark differences between the species. B: male tail in lateral view. Arrow points to precloacal hook, arrowhead points to distal part of gubernaculum which is bent dorsally in living animals. C and F: cloacal region with precloacal hook and distal part of gubernaculum in situ. D and G: isolated gubernaculum in ventral view and spicules (G). Note that the two lateral processes (ears) are larger and more strongly refractive in C. brenneri sp. n. than in C. remanei. Scale is the same in Figs. A, B, E; and in Figs. C, D, F, G, respectively.
Deep Learning for Microfluidic Assisted Caenorhabditis elegans Multi-parameter Identification Using YOLOv7
<p>The effectiveness of deep learning model relies on a large number of labeled image datasets. We have collected a dataset of 3373 worm images from microfluidic devices in various studies as datasets. Then, the datasets were labeled for training methods. The acquired videos were continuously intercepted at 10-frame intervals to capture cropped worm images. Totally 3931 images were extract. Worms in each image were manually annotated using LabelImg. This VOC-format annotation tool generated Extensible Markup Language (XML) files for the model. There were 2426 labels for the WT category and 1505 for the GFP category.</p>
Tocchini and Mango_An adapted MS2-MCP system to visualize endogenous cytoplasmic mRNA with live imaging in Caenorhabditis elegans_Table S1_Raw data
<p><strong>Table S1. Raw data.</strong> List of quantitation of GFP intensities of heads (<em>spc-1</em>) or pharynges (<em>dlg-1</em>) in the different figures.</p>
Pre-exposed gut bacteria of Caenorhabditis elegans in Martian conditions
<p>Student project on experimental evolution of C. elegans gut microbes under conditions simulating the atmosphere of Mars. </p>
Data from: Genetic or toxicant-induced disruption of vesicular monoamine storage and global metabolic profiling in Caenorhabditis elegans
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Data from: The mutational structure of metabolism in Caenorhabditis elegans
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Data from: The Red Death meets the abdominal bristle: polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans
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Data from: Maximally informative foraging by Caenorhabditis elegans
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Data from: Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans
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Data from: Dauer life stage of Caenorhabditis elegans induces elevated levels of defense against the parasite Serratia marcescens
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Data from: Fitness decline under osmotic stress in Caenorhabditis elegans populations subjected to spontaneous mutation accumulation at varying population sizes
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Impact of the POLRMT inhibitor IMT1B on mitochondrial genome copy number in Caenorhabditis elegans
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Data from: The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans
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Developmental exposures to three mammalian teratogens produces dysmorphic phenotypes in adult Caenorhabditis elegans.
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Data from: Mutation is a sufficient and robust predictor of genetic variation for mitotic spindle traits in Caenorhabditis elegans
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.