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1,088
datasets available to search
ShareScore release 0.9.0
Dataset results
1,088 results for “Cardiomyopathy”
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Diastolic Cardiomyopathy (Aim3)
ClinicalTrials.gov study NCT02058095. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Stem Cell Treatment for Adults With Ischemic Cardiomyopathy (The FOCUS Study)
ClinicalTrials.gov study NCT00824005. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy
ClinicalTrials.gov study NCT03470545. IPD Sharing: Not stated. Countries: 13. Publications: 14.
A Phase 2 Open-label Pilot Study Evaluating MYK-461 in Subjects With Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
ClinicalTrials.gov study NCT02842242. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Rollover Study of ARRY-371797 in Patients With LMNA-Related Dilated Cardiomyopathy
ClinicalTrials.gov study NCT02351856. IPD Sharing: YES. Countries: 1. Publications: 3.
APOLLO-B: A Study to Evaluate Patisiran in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
ClinicalTrials.gov study NCT03997383. IPD Sharing: YES. Countries: 22. Publications: 2.
A Study of ARRY-371797 (PF-07265803) in Patients With Symptomatic Dilated Cardiomyopathy Due to a Lamin A/C Gene Mutation
ClinicalTrials.gov study NCT03439514. IPD Sharing: YES. Countries: 10. Publications: 4.
Novel Cardiac Magnetic Resonance Imaging to Define a Unique Restrictive Cardiomyopathy in Sickle Cell Disease
ClinicalTrials.gov study NCT02410811. IPD Sharing: NO. Countries: 1. Publications: 5.
Extension Study of Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy Previously Enrolled in PIONEER
ClinicalTrials.gov study NCT03496168. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Multi-omic, histopathologic, and clinicopathologic effects of once-weekly oral rapamycin in a naturally occurring feline model of hypertrophic cardiomyopathy: A pilot study
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Novel DMD mouse model carrying a multi-exonic Dmd deletion exhibit progressive muscular dystrophy and early-onset cardiomyopathy
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Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling
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Data from: Robotic manipulation of cardiomyocytes to identify gap junction modifiers for arrhythmogenic cardiomyopathy
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Unraveling the genetics of feline hypertrophic cardiomyopathy: A multiomics study of 138 cats
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A specific IL6 polymorphic genotype modulates the risk of T. cruzi parasitemia while IL18, IL17A and IL1B variant profiles and HIV infection protect against cardiomyopathy in Chagas disease
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Optical Trapping Data for the manuscript "Myosin with hypertrophic cardiomyopathy mutation R712L has a reduced working stroke which is rescued by omecamtiv mecarbil"
<p>Optical Trapping Data for the manuscript "Myosin with hypertrophic cardiomyopathy mutation R712L has a reduced working stroke which is rescued by omecamtiv mecarbil"</p>
Data from: The demanding grey zone: sport indices by cardiac magnetic resonance imaging differentiate hypertrophic cardiomyopathy from athlete's heart
Background: We aimed to characterize gender specific left ventricular hypertrophy using a novel, accurate and less time demanding cardiac magnetic resonance (CMR) quantification method to differentiate physiological hypertrophy and hypertrophic cardiomyopathy based on a large population of highly trained athletes and hypertrophic cardiomyopathy patients. Methods and Results: Elite athletes (n=150,>18 training hours/week), HCM patients (n=194) and athletes with hypertrophic cardiomyopathy (n=10) were examined by CMR. CMR based sport indices such as maximal end-diastolic wall thickness to left ventricular end-diastolic volume index ratio (EDWT/LVEDVi) and left ventricular mass to left ventricular end-diastolic volume ratio (LVM/LVEDV) were calculated, established using both conventional and threshold-based quantification method. Whereas 47.5% of male athletes, only 4.1% of female athletes were in the grey zone of hypertrophy (EDWT 13-16mm). EDWT/LVEDVi discriminated between physiological and pathological left ventricular hypertrophy with excellent diagnostic accuracy (AUCCQ:0.998, AUCTQ:0.999). Cut-off value for LVM/LVEDVCQ<0.82 mm×m2/ml and for EDWT/LVEDViTQ<1.27 discriminated between physiological and pathological left ventricular hypertrophy with a sensitivity of 77.8% and 89.2%, a specificity of 86.7% and 91.3%, respectively. LVM/LVEDV evaluated using threshold-based quantification performed significantly better than conventional quantification even in the male subgroup with EDWT between 13-16mm (p<0.001). Conclusions: Almost 50% of male highly trained athletes can reach EDWT of 13 mm. CMR based sport indices provide an important tool to distinguish hypertrophic cardiomyopathy from athlete's heart, especially in highly trained athletes in the grey zone of hypertrophy.
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
<p>Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy</p> <p>(ACM) convey high risks for the development of heart failure through unknown mechanisms. Using</p> <p>single-nucleus RNA sequencing, we characterized the transcriptome of 880,000 nuclei from 18 control and</p> <p>61 failing, nonischemic human hearts with pathogenic variants in DCM and ACM genes or idiopathic</p> <p>disease. We performed genotype-stratified analyses of the ventricular cell lineages and transcriptional</p> <p>states. The resultant DCM and ACM ventricular cell atlas demonstrated distinct right and left ventricular</p> <p>responses, highlighting genotype-associated pathways, intercellular interactions, and differential gene</p> <p>expression at single-cell resolution. Together, these data illuminate both shared and distinct cellular and</p> <p>molecular architectures of human heart failure and suggest candidate therapeutic targets.</p> <p> </p> <p>Link to article: https://www.science.org/doi/10.1126/science.abo1984</p> <p>To match Clinical information (supplementary information) with Sample IDs on Zenodo, please access the Excel table "Additional_note_samples.xlsx" on the github repository: https://github.com/heiniglab/DCM_heart_cell_atlas</p>
Prediction of Delayed Toxic Cardiomyopathy in Children
ClinicalTrials.gov study NCT05781672. IPD Sharing: YES. Countries: 1. Publications: 1.
The Perceived Impact of Children s Risk Status for Hypertrophic Cardiomyopathy on Families: an Exploratory Study
ClinicalTrials.gov study NCT01160536. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.