Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
315
datasets available to search
ShareScore release 0.9.0
Dataset results
315 results for “Cortisol”
Data from: Hair and plasma cortisol throughout the first three years of development in infant rhesus macaques, Macaca mulatta
Open the record for dataset details and reuse information.
HRV and salivary cortisol data in pregnant women
Open the record for dataset details and reuse information.
Data from: Stressed connections: cortisol levels following acute psychosocial stress disrupt affiliative mimicry in humans
Mimicry, and especially spontaneous facial mimicry, is a rudimentary element of social–emotional experience that is well-conserved across numerous species. Although such mimicry is thought to be a relatively automatic process, research indicates that contextual factors can influence mimicry, especially in humans. Here, we extend this work by investigating the effect of acute psychosocial stress on spontaneous facial mimicry. Participants performed a spontaneous facial mimicry task with facial electromyography (fEMG) at baseline and approximately one month later, following an acute psychosocial stressor (Trier Social Stress Test). Results show that the magnitude of the endocrine stress response reduced zygomaticus major reactivity, and specifically spontaneous facial mimicry for positive social stimuli (i.e. smiles). Individuals with higher levels of the stress hormone cortisol showed a more blunted fEMG response to smiles, but not to frowns. Conversely, stress had no effect on corrugator supercilii activation (i.e. frowning to frowns). These findings highlight the importance of the biological stress response system in this basic element of social–emotional experience.
Data from: Circulating cortisol and cognitive and structural brain measures in a middle-aged cohort: the Framingham Heart Study
Objective: To assess the association of early morning serum cortisol with cognitive performance and brain structural integrity in community-dwelling young and middle-aged adults without dementia. Methods: We evaluated dementia-free Framingham Study (Generation 3) participants (mean age 48.5 years; 46.8% men), who underwent cognitive testing for memory, abstract reasoning, visual perception, attention, and executive function (n= 2231), and brain MRI (n=2018) to assess total white matter, lobar gray matter, and white matter hyperintensity volumes and fractional anisotropy (FA) measures. We used linear and logistic regression to assess the relations of cortisol (categorized in tertiles, with the middle tertile as referent) to measures of cognition, MRI volumes, presence of covert brain infarcts (CBI) and cerebral microbleeds (CMB), and voxel-based microstructural white matter integrity and gray matter density, adjusting for age, sex, APOE and vascular risk factors. Results: Higher cortisol (highest tertile vs. middle tertile) was associated with worse memory and visual perception, as well as lower total cerebral brain, occipital and frontal lobar gray matter volumes. Higher cortisol was associated with multiple areas of microstructural changes (decreased regional FA), especially in the splenium of corpus callosum and the posterior corona radiata. The association of cortisol with total cerebral brain volume varied by sex (p interaction=0.048); higher cortisol was inversely associated with cerebral brain volume in women [p=0.001] but not in men [p=0.717]). There was no effect modification by the apoE4 genotype of the relations of cortisol and cognition or imaging traits. Conclusions: Higher serum cortisol was associated with lower brain volumes and impaired memory in asymptomatic younger to middle-aged adults, with the association being evident particularly in women.
Data from: Cortisol advantage of neighbouring the opposite sex in utero
Population sex ratios naturally fluctuate around equality. It is argued that the production of an equal number of male and female offspring by individual parents should be favoured by selection, if all costs and benefits are equal. Theoretically, an even-sex ratio should yield the highest probability for a fetus to be adjacent to a fetus of the opposite sex in utero. This may cause developmental costs or benefits that have been overlooked. We examined the physiological and developmental parameters associated with in utero sex ratios in the nutria (Myocastor coypus), an invasive wildlife species with a strong reproductive output. Using hair-testing, we found that litters with even-sex ratios had the highest average cortisol levels. Fetuses neighbouring the opposite sex exhibited longer trunks than those neighbouring the same sex, which might imply better lung development. Our results are the first to link intra-utero sex ratios and fetal cortisol and suggest that fetal cortisol might be a mechanism by which even-sex ratios are maintained via developmental advantages.
Data from: Tryptophan and Cortisol modulate the Kynurenine and Serotonin transcriptional pathway in the kidney of Oncorhynchus kisutch
<p>Aquaculture fish are kept for long-periods in sea cages or tanks. Consequently, accumulated stress causes the fish to present serious problems with critical economic losses. Fish food has been supplemented to reduce the stress, using many compoment as amino acids such as tryptophan. This study aims to determine the transcriptional effect of tryptophan and cortisol on primary cell cultures of salmon head and posterior kidney. Our results indicate activation of the kynurenine pathway and serotonin activity when stimulated with tryptophan and cortisol. 95% of tryptophan is degraded by the kynurenine pathway, indicating the relevance of knowing how this pathway is activated and if stress levels associated with fish culture trigger its activation. Additionally, it is essential to know the consequence of increasing kynurenic acid "KYNA" levels in the short and long term, and even during the fish ontogeny.</p>
Severe hypoxia exposure inhibits larval brain development but does not affect the capacity to mount a cortisol stress response in zebrafish
<p>Fish nursery habitats are increasingly hypoxic and the brain is recognized as highly hypoxia-sensitive, yet there is a lack of information on the effects of hypoxia on the development and function of the larval fish brain. Here, we tested the hypothesis that by inhibiting brain development, larval exposure to severe hypoxia has persistent functional effects on the cortisol stress response in zebrafish (<i>Danio rerio</i>). Exposing 5 days post-fertilization (dpf) larvae to 10% dissolved O<sub>2</sub> (DO) for 16 h only marginally reduced survival, but it decreased forebrain neural proliferation by 55%, and reduced the expression of <i>neurod1</i>, <i>gfap,</i> and <i>mbpa, </i>markers of determined neurons, glia, and oligodendrocytes, respectively. The 5 dpf hypoxic exposure also elicited transient increases in whole body cortisol and in <i>crf</i>, <i>uts1</i>, and <i>hsd20b2</i> expression, key regulators of the endocrine stress response. Hypoxia exposure at 5 dpf also inhibited the cortisol stress response to hypoxia in 10 dpf larvae and increased hypoxia tolerance. However, 10% DO exposure at 5 dpf for 16h did not affect the cortisol stress response to a novel stressor in 10 dpf larvae or the cortisol stress response to hypoxia in adult fish. Therefore, while larval exposure to severe hypoxia can inhibit brain development, it also increases hypoxia tolerance. These effects may transiently reduce the impact of hypoxia on the cortisol stress response but not its functional capacity to respond to novel stressors. We conclude that the larval cortisol stress response in zebrafish has a high capacity to cope with severe hypoxia-induced neurogenic impairment.</p>
Cortisol assay readings
<p>Cortisol assay readings </p>
Hair Cortisol and the Risk of Stroke
ClinicalTrials.gov study NCT02090270. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hair Cortisol in Asthma or Allergic Rhinitis Treated With Topical Corticosteroids
ClinicalTrials.gov study NCT01839851. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Adrenal IncidenTalomas and Possible Autonomous Cortisol Secretion on Cardiovascular and Metabolic Alterations
ClinicalTrials.gov study NCT04127552. IPD Sharing: NO. Countries: 1. Publications: 1.
Cortisol in the Treatment of Phobias
ClinicalTrials.gov study NCT00451750. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17
ClinicalTrials.gov study NCT03558971. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of Isometric Neck Exercises on Cervicogenic Headache, Cortisol, and BDNF in Adolescents With Smartphone Addiction
ClinicalTrials.gov study NCT07354776. IPD Sharing: YES. Countries: 1. Publications: 4.
Performances on Cognitive Functions and Brain Function and Follow-up After Different Treatments in Patients With Autonomous Cortisol Secretion: a Single-center, Prospective, Observational Study
ClinicalTrials.gov study NCT05357456. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Association Between Low Cortisol Levels and Whiplash Syndrome
ClinicalTrials.gov study NCT02090309. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Isturisa Treatment in Mild Autonomous Cortisol Secretion( MACS)
ClinicalTrials.gov study NCT07247058. IPD Sharing: NO. Countries: 1. Publications: 14.
Ghrelin, Growth Hormone and Cortisol Interaction in Growth Hormone Deficient Patients
ClinicalTrials.gov study NCT00139945. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
ClinicalTrials.gov study NCT06635993. IPD Sharing: NO. Countries: 1. Publications: 15.
EFT and Music on Psychological Development, Well-Being Status and Cortisol Level in Pregnant Women
ClinicalTrials.gov study NCT05344144. IPD Sharing: NO. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.