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483
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Dataset results
483 results for “Drug therapy”
Drug Therapy Induced Weight Loss to Improve Blood Vessel Function in Subjects With Obesity
ClinicalTrials.gov study NCT01351753. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of the Efficacy and Safety of 2 Doses of Retigabine Immediate Release (900 mg/Day and 600 mg/Day) Used as Adjunctive Therapy in Adult Asian Subjects With Drug-resistant Partial-onset Seizur
ClinicalTrials.gov study NCT01648101. IPD Sharing: YES. Countries: 7. Publications: 1.
Monoclonal Antibody Against PCSK9 to Reduce Elevated LDL-C in Subjects Currently Not Receiving Drug Therapy for Easing Lipid Levels-2
ClinicalTrials.gov study NCT01763827. IPD Sharing: Not stated. Countries: 10. Publications: 11.
Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic Arthritis
ClinicalTrials.gov study NCT00443430. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Before-after Comparison of Pharmacist Drug Therapy Management in Pediatric Hypertension
ClinicalTrials.gov study NCT04098978. IPD Sharing: YES. Countries: 1. Publications: 13.
Open-Label Study Comparing Etanercept to Conventional Disease Modifying Antirheumatic Drug (DMARD) Therapy
ClinicalTrials.gov study NCT00848354. IPD Sharing: Not stated. Countries: 5. Publications: 5.
An Efficacy and Safety Study of Daratumumab in Patients With Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy (Including a Proteasome Inhibitor [PI] and Immunomodulatory Drug [IMiD
ClinicalTrials.gov study NCT01985126. IPD Sharing: Not stated. Countries: 3. Publications: 6.
A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Asthma Uncontrolled on Low-Dose ICS Therapy.
ClinicalTrials.gov study NCT00603278. IPD Sharing: YES. Countries: 13. Publications: 3.
Dual Drug Delivery in Cancer Therapy Using Graphene Oxide-Based Nanoplatforms
Open the record for dataset details and reuse information.
Nanocomposite formulation for a sustained release of free drug and drug-loaded responsive nanoparticles: an approach for a local therapy of glioblastoma multiforme
<p>Malignant gliomas are a type of primary brain tumour that originates in glial cells. Among them, glioblastoma multiforme (GBM) is the most common and the most aggressive brain tumour in adults, classified as grade IV by the World Health Organization. The standard care for GBM, known as the Stupp protocol includes surgical resection followed by oral chemotherapy with temozolomide (TMZ). This treatment option provides a median survival prognosis of only 16–18 months to patients mainly due to tumour recurrence. Therefore, enhanced treatment options are urgently needed for this disease. Here we show the development, characterization, and in vitro and in vivo evaluation of a new composite material for local therapy of GBM post-surgery. We developed responsive nanoparticles that were loaded with paclitaxel (PTX), and that showed penetration in 3D spheroids and cell internalization. These nanoparticles were found to be cytotoxic in 2D (U-87 cells) and 3D (U-87 spheroids) models of GBM. The incorporation of these nanoparticles into a hydrogel facilitates their sustained release in time. Moreover, the formulation of this hydrogel containing PTX-loaded responsive nanoparticles and free TMZ was able to delay tumour recurrence in vivo after resection surgery. Therefore, our formulation represents a promising approach to develop combined local therapies against GBM using injectable hydrogels containing nanoparticles.</p>
Drug-drug Interactions Between Remdesivir and Commonly Used Antiretroviral Therapy
ClinicalTrials.gov study NCT04385719. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment With Interleukin-2 (IL-2) Plus Combination Anti-HIV-Drug Therapy (HAART) for Patients Formerly in ACTG 328
ClinicalTrials.gov study NCT00000923. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Duration of Clopidogrel Therapy After Drug-Eluting Stent (DES-LATE)
ClinicalTrials.gov study NCT01186146. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of JNJ-40346527 in Patients With Active Rheumatoid Arthritis Despite Disease-modifying Antirheumatic Drug Therapy
ClinicalTrials.gov study NCT01597739. IPD Sharing: Not stated. Countries: 10. Publications: 1.
Cognitive Behavioral Therapy Combined With Antidepressants to Reduce HIV Risk and Drug Relapse Among Depressed Intravenous Drug Users
ClinicalTrials.gov study NCT00183768. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa
ClinicalTrials.gov study NCT01975441. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Hyponatremia in the Elderly: Benefit From a Change in Drug Therapy?
ClinicalTrials.gov study NCT01212211. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Real-World Study of Magnetic Resonance-guided Laser Interstitial Thermal Therapy for Drug-resistant Epilepsy
ClinicalTrials.gov study NCT06341075. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Comparison of Anti-Ischemic Drug Therapy and Percutaneous Transluminal Angioplasty After Myocardial Infarction
ClinicalTrials.gov study NCT00387231. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Drug Therapy in Lupus Nephropathy
ClinicalTrials.gov study NCT00001212. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.