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178
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Dataset results
178 results for “Environmental Exposure*”
Family-based Childhood Behavior Intervention to Decrease Environmental Melamine and Phthalate Exposure
ClinicalTrials.gov study NCT02724722. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm
ClinicalTrials.gov study NCT00012480. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Case-control Study to Assess the Association Between Environmental, Domestic and Occupational Exposures and the Risk of Testicular Germ Cell Tumor
ClinicalTrials.gov study NCT02109926. IPD Sharing: Not stated. Countries: 1. Publications: 44.
Multiple Myeloma and Environmental Exposure to Pesticides in the French West Indies: A Population Based Case-control Study.
ClinicalTrials.gov study NCT04260490. IPD Sharing: NO. Countries: 2. Publications: 2.
Data from: Primary care clinics can be a source of exposure to virulent Clostridium (now Clostridioides) difficile: an environmental screening study of hospitals and clinics in Dallas-Fort Worth region
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Data from: Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
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Data from: Increased transgenerational epigenetic variation, but not predictable epigenetic variants, after environmental exposure in two apomictic dandelion lineages
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Data from: Use of environmental sites by mule deer: a proxy for relative risk of chronic wasting disease exposure and transmission
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Environmental exposure model for copper oxide nanoparticles impact in estuarine ecosystem services
<p>Modelling the effect of copper oxide nanoparticles (< 50 nm) on denitrification rate and abundance and transcription of genes of the denitrification pathway on a temperate estuary.</p>
Early life exposure to environmental contaminants (BDE-47, TBBPA, and BPS) produced persistent gut dysbiosis in adult male mice
<p><span>The gut microbiome is a pivotal player in toxicological responses. We investigated the effects of maternal exposure to 3 human health-relevant toxicants (BDE-47, TBBPA, and BPS) on the composition and metabolite levels (bile acids [BAs] and short chain fatty acids [SCFAs]) of the gut microbiome in adult pups. CD-1 mouse dams were orally exposed to vehicle (corn oil, 10ml/kg), BDE-47 (0.2 mg/kg), TBBPA (0.2 mg/kg), or BPS (0.2 mg/kg) once daily from gestational day 8 to the end of lactation (postnatal day 21). 16S rRNA sequencing and targeted metabolomics were performed in fecal DNA of 12-week-old adult male pups (n=14-23/group). BPS had the most prominent effect on the beta-diversity of the fecal microbiome compared to TBPPA and BDE-47 (QIIME). Seventy-three taxa were persistently altered by at least 1 chemical, and 12 taxa were commonly regulated by all chemicals (most of which were from the <i>Clostridia</i> class and were decreased). The most distinct microbial biomarkers were <i>S24-7</i> for BDE-47,<i> Rikenellaceae </i>for TBPPA, and <i>Lactobacillus</i> for BPS (LefSe). The community-wide contributions to the shift in microbial pathways were predicted using FishTaco. Fecal BA output was persistently increased by all chemicals (LC-MS). TBBPA increased propionic acid and succinate, whereas BPS decreased acetic acid (GC-MS. In conclusion, maternal exposure to these toxicants persistently modified fecal microbiome and metabolites later in life, and dysbiosis may contribute to the mechanisms of developmental origins of adult-onset of toxic outcomes. </span></p>
Data from: The association between exposure to environmental bisphenol A and gonadotropic hormone levels among men
Bisphenol A (BPA) is an extensively used chemical with endocrine disrupting properties. Although animal and in vivo studies have suggested possible effects of BPA on levels of gonadotropic hormones, human studies are limited and inconclusive. The study examined whether environmental BPA exposure was associated with gonadotropic hormones levels in men. A total of 560 men aged 18–55 years were recruited from Sandu County, Guizhou Province, China. We collected urine samples for measurement of BPA, and blood samples for measurement of reproductive hormones. We examined serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone (T). Relative risk (RR) was obtained by log-binominal regression to explore the association between urinary BPA level and hormone levels. BPA was detected in 70.4% of urine samples, with a geometric mean of 0.50 μg/gCr. Men with detectable levels of BPA had a 1.52-fold increased risk of having a high LH level (>75th percentile) when compared with men with undetectable levels of BPA, after adjustment for potential confounders (95% confidence interval (CI): 1.04–2.21). The association persisted and slightly intensified among current smokers (adjusted RR (aRR) = 1.76, 95%CI: 1.05–2.95), while it weakened among non-smokers (aRR = 1.17, 95%CI: 0.69–1.96). Urinary BPA level was associated with an increased FSH level among smokers (aRR = 1.64, 95%CI: 1.01–2.67). Urinary BPA level was inversely associated with total T level among males with body max index (BMI) ≥25 kg/m2 although this association was of borderline significance (aRR = 0.52, 95%CI: 0.26–1.05). In conclusion, environmental exposure to BPA was associated with increased serum levels of LH and FSH in male smokers, along with decreased serum levels of total T in men with BMI≥25 kg/m2. These findings suggest that the effects of environmental BPA exposure on hormone levels might be modified by smoking and BMI.
Supplementary material 3 from: McNeill MR, Phillips CB, Robinson AP, Aalders L, Richards N, Young S, Dowsett C, James T, Bell N (2017) Defining the biosecurity risk posed by transported soil: Effects of storage time and environmental exposure on survival of soil biota. NeoBiota 32: 65-88. https://doi.org/10.3897/neobiota.32.9784
Soil chemistry of the two soil sources :
Supplementary material 2 from: McNeill MR, Phillips CB, Robinson AP, Aalders L, Richards N, Young S, Dowsett C, James T, Bell N (2017) Defining the biosecurity risk posed by transported soil: Effects of storage time and environmental exposure on survival of soil biota. NeoBiota 32: 65-88. https://doi.org/10.3897/neobiota.32.9784
Plant species common to both soil sources :
Supplementary material 1 from: McNeill MR, Phillips CB, Robinson AP, Aalders L, Richards N, Young S, Dowsett C, James T, Bell N (2017) Defining the biosecurity risk posed by transported soil: Effects of storage time and environmental exposure on survival of soil biota. NeoBiota 32: 65-88. https://doi.org/10.3897/neobiota.32.9784
Description of the data analysis methods and results :
Aconitate Decarboxylase 1 Mediates the Acute Airway Inflammatory Response to Environmental Exposures
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Safety, Pharmacokinetics, and Efficacy of Bepotastine Besilate Nasal Product After Ragweed Pollen Exposure in an Environmental Chamber
ClinicalTrials.gov study NCT01222299. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Prototype for Simulation for Environmental Exposure Education (SE3)
ClinicalTrials.gov study NCT05875467. IPD Sharing: NO. Countries: 1. Publications: 0.
Impact of the Modifications of Environmental Exposures and Health Care Access During COVID-19 Lockdown on Multiple Sclerosis
ClinicalTrials.gov study NCT05033782. IPD Sharing: YES. Countries: 1. Publications: 0.
A Methodology Development Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis Using the Environmental Exposure Chamber
ClinicalTrials.gov study NCT03709121. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessing and Addressing Community Exposures to Environmental Contaminants
ClinicalTrials.gov study NCT06315140. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.