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984 results for “Extracellular Vesicles”
Proteins identified from tumor-derived extracellular vesicles using mass spectrometry
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The cellular response to extracellular vesicles is dependent on their cell source and dose
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Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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Data from: Pharmacological HIF-1 activation upregulates extracellular vesicle production synergistically with adiponectin through transcriptional induction and protein stabilization of T-cadherin
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Data from: Vaginal bacteria-derived extracellular vesicles diffuse through human cervicovaginal mucus to enable microbe-host signaling
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Data from: Identifying extracellular vesicles from single cells
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Extracellular Vesicles from Pneumocystis carinii-infected rats impair fungal viability but are dispensable for macrophage functions
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Dataset for: Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis
<p>This upload contains the data extracted from studies included in our meta-analysis entitled "Therapeutic potential of extracellular vesicles in preclinical stroke models: a systematic review and meta-analysis". It also contains the code used to perform the meta-analysis and generate the figures in the publication in R. </p>
Dataset related to article "Intracerebral Injection of Extracellular Vesicles from Mesenchymal Stem Cells Exerts Reduced Aβ Plaque Burden in Early Stages of a Preclinical Model of Alzheimer's Disease."
<p>Bone marrow Mesenchymal Stem Cells (BM-MSCs), due to their strong protective and anti-inflammatory abilities, have been widely investigated in the context of several diseases for their possible therapeutic role, based on the release of a highly proactive secretome composed of soluble factors and Extracellular Vesicles (EVs). BM-MSC-EVs, in particular, convey many of the beneficial features of parental cells, including direct and indirect β-amyloid degrading-activities, immunoregulatory and neurotrophic abilities. Therefore, EVs represent an extremely attractive tool for therapeutic purposes in neurodegenerative diseases, including Alzheimer's disease (AD). We examined the therapeutic potential of BM-MSC-EVs injected intracerebrally into the neocortex of APPswe/PS1dE9 AD mice at 3 and 5 months of age, a time window in which the cognitive behavioral phenotype is not yet detectable or has just started to appear. We demonstrate that BM-MSC-EVs are effective at reducing the Aβ plaque burden and the amount of dystrophic neurites in both the cortex and hippocampus. The presence of Neprilysin on BM-MSC-EVs, opens the possibility of a direct β-amyloid degrading action. Our results indicate a potential role for BM-MSC-EVs already in the early stages of AD, suggesting the possibility of intervening before overt clinical manifestations.</p>
Data from: Profiling extracellular long RNA transcriptome in human plasma and extracellular vesicles for biomarker discovery
<p>The recent discovery of extracellular RNAs in blood, including RNAs in extracellular vesicles (EVs), combined with low-input RNA-sequencing advances have enabled scientists to investigate their role in human disease. To date, most studies have been focusing on small RNAs, and methodologies to optimize long RNAs measurement are lacking. We used plasma RNA to assess the performance of six long RNA sequencing methods, at two different sites, and we report their differences in reads (%) mapped to the genome/transcriptome, number of genes detected, long RNA transcript diversity, and reproducibility. Using the best performing method, we further compare the profile of long RNAs in the EV- and no-EV-enriched RNA plasma compartments. These results provide insights on the performance and reproducibility of commercially available kits in assessing the landscape of long RNAs in human plasma and different extracellular RNA carriers that may be exploited for biomarker discovery.</p>
Towards establishing extracellular vesicle-associated RNAs as biomarkers for HER2+ breast cancer
<p class="Abstract">Extracellular vesicles (EVs) are emerging as key players in breast cancer progression and hold immense promise as cancer biomarkers. However, difficulties in obtaining sufficient quantities of EVs for the identification of potential biomarkers hampers progress in this area. To circumvent this obstacle, we cultured BT-474 breast cancer cells in a two-chambered bioreactor with CDM-HD serum replacement to significantly improve the yield of cancer cell-associated EVs and eliminate bovine EV contamination. Cancer-relevant mRNAs <i>BIRC5 </i>(Survivin) and <i>YBX1</i>,<i> </i>as well as long-noncoding RNAs <i>HOTAIR</i>, <i>ZFAS1</i>, and <i>AGAP2-AS1 </i>were detected in BT-474 EVs by quantitative RT-PCR. Bioinformatics meta-analyses showed that <i>BIRC5 </i>and <i>HOTAIR </i>RNAs were substantially upregulated in breast tumours compared to non-tumour breast tissue, warranting further studies to explore their usefulness as biomarkers in patient EV samples. We envision this effective procedure for obtaining large amounts of cancer-specific EVs will accelerate discovery of EV-associated RNA biomarkers for cancers including HER2+ breast cancer.</p>
AFM-Based High-Throughput Nanomechanical Screening of Single Extracellular Vesicles
<p>I the present study, a novel AFM-based high throughput mechanical characterization for extracellular vesicles is presented. The method relies on the analysis of vesicles morphometry following their adsorption on surfaces. The deformation extent of the vesicle, which is representative of the vesicle stiffness, is evaluated by the calculation of the so-called vesicle contact angle. The method was applied to different etracellular vesicles (EVs) samples from different natural sources and was employed for spotting the presence of non-vesicular contaminants.</p>
Development of a multivariable risk model integrating urinary peptide metabolites and Extracellular Vesicle RNA data to detect significant prostate cancer
<p>The aim of this study was to investigate whether the robust integration of expression data from urinary extracellular vesicle RNA (EV-RNA) with urine proteomic metabolites can accurately predict PCa biopsy outcome. Urine samples were analyzed by mass spectrometry and NanoString gene-expression analysis. As a result, four classifiers were generated: ‘MassSpec’ (CE-MS proteomics), ‘EV-RNA’, ‘SoC’ (standard of care) and ‘ExoSpec’. The best prediction for Gs³3+4 at initial biopsy (AUC=0.83, 95% CI:0.77-0.88) was achieved by applying ‘ExoSpec’ classifier and he outperformed other predictive classifiers. In addition, the results showed that the performance of ‘ExoSpec’ could reduce unnecessary biopsies by 30%.</p>
Figures for the publication ''The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy''
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Source data for "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells"
<p>Source Data include all reported experimental data and plasmid maps for all plasmids generated in the associated publication, "Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells," which is in press at Nature Biomedical Engineering.</p>
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
ClinicalTrials.gov study NCT06713902. IPD Sharing: NO. Countries: 1. Publications: 1.
Extracellular Vesicles, Insulin Action, and Exercise
ClinicalTrials.gov study NCT06546085. IPD Sharing: NO. Countries: 1. Publications: 9.
Saliva and Extracellular Vesicles for Neurodegenerative Diseases
ClinicalTrials.gov study NCT06869135. IPD Sharing: NO. Countries: 1. Publications: 2.
Role of Mesenchymal Stromal Cell Derived Extracellular Vesicles of Primary Myelofibrosis Patients on CD34+ Cells
ClinicalTrials.gov study NCT06896344. IPD Sharing: NO. Countries: 1. Publications: 2.
Deciphering the Role of Dietary Fatty Acids on Extracellular Vesicles-mediated Intercellular Communication
ClinicalTrials.gov study NCT06051461. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.