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4,582 results for “Gene regulation”
Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci
<p>All full-sample files contain results generated in coronary artery tissue from 138 American adults. Subset analyses utilized 80 individuals selected from the original 138. Scripts accompanying some of these data in downstream analyses can be viewed on our Github, which also contains a link to the current version of our accompanying manuscript: https://github.com/MillerLab-CPHG/CAD_QTL</p> <p>Full summary statistics for eQTL associations using mixQTL (https://github.com/hakyimlab/mixqtl/wiki) by chromosome are located in UVA_coronary_mixQTL_sumstats_by_chromosome.zip</p> <p>Full summary statistics for eQTL associations using mixQTL in the subset of 100% European-ancestry study sample members by chromosome are located in Hodonsky_mixQTL_Euro_sumstats.zip</p> <p>Full summary statistics for eQTL associations using mixQTL in the genetically diverse downsampled subset by chromosome are located in Hodonsky_mixQTL_downsample_sumstats.zip</p> <p>Full summary statistics for nominal pass for all genes identified as significant in the permutation pass using QTLtools (https://qtltools.github.io/qtltools/) adjusting for local ancestry by gene by chromosome are located in Local_ancestry_UVA_coronary_QTLtools_nominal_sumstats.zip</p> <p>Full summary statistics for sQTL associations with splice junctions using QTLtools by gene are located in sQTL_results_UVA_coronary_full_sumstats.zip</p>
Massive Chinese domestic pigs provide missing sequences in reference genome and reveal non-coding sequence variations regulating gene expression across Eurasian boars
<p>This dataset contains novel sequences in Chinese domestic pigs but is absent in Sscrofa 11.1 reference genome. The detailed information for each file is recorded in the README file.</p>
Threshold-dependent gene regulation and partial assortative mating determine wing dimorphism of an Insect
<p><span>Wing dimorphism is a fantastic</span> <span>life-historical trait of insects which indicates the developmental trend of populations, going as migrants or staying as residents. The alternative wing morph enhances adaptability of insects to changing environments. However, the underlying mechanism for maintaining wing dimorphism remains vague. The brown planthoppers <em>Nilaparvata lugens</em>, a serious pest of rice, are either short-winged or long-winged. The shift between two wing morphs is determined by two insulin receptors. So, this pest is a better model organism to explore the mechanism of wing dimorphism. Here, the short- and long-winged strains of <em>N. lugens</em> were selected. Rates of a selected wing morph were linearly increased in populations, and the selection response of the short-winged morph was stronger than that of the long-winged. Selection enhanced the migratory or resident propensity. Directional selection for the long-winged morph resulted in longer and lighter forewings, while selection for the short-winged morph generated shorter and thicker wings and higher fecundity. Relative expression levels of wing development genes <em>InR1, InR2</em>, and <em>FOXO</em> were positively correlated with the short-winged rate in the short-winged strain, while they were negatively correlated with the long-winged rate in the long-winged strain at specific stages. The change rate of expression levels was approximately two times as high as that of the wing morph rates in populations, indicating a high threshold-dependent gene expressed regulation of a wing morph. A partial assortative mating behavior occurred between the nearly pure-bred lineages of short- and long-winged strains. The short-winged males preferred to mate with short-winged females while the long-winged males mated with the short- and long-winged females equally. The threshold-dependent mode is flexible to adjust the wing morph according to environmental conditions and the partial assortative mating promotes the genetic exchange between two wing morphs which drive the maintenance of wing dimorphism.</span></p>
Gene Therapy for X-linked Retinitis Pigmentosa (XLRP) - Retinitis Pigmentosa GTPase Regulator (RPGR)
ClinicalTrials.gov study NCT03252847. IPD Sharing: NO. Countries: 2. Publications: 1.
Roll-Over Study of Ivacaftor in Cystic Fibrosis Pediatric Subjects With a CF Transmembrane Conductance Regulator Gene (CFTR) Gating Mutation
ClinicalTrials.gov study NCT01946412. IPD Sharing: Not stated. Countries: 3. Publications: 1.
DNA-PKcs RNASeq data: DNA-PKcs wilde-type or kinase-dead protein regulate basal and etoposide-induced gene expression changes
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Data from: Regulators of an ancient polyphenism evolved through episodic protein divergence and parallel gene radiations
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Data from: Decoupling transcription factor expression and activity enables dimmer switch gene regulation
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A library of reporters of the global regulators of gene expression of Escherichia coli
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Two modes of gene regulation by TFL1 mediate its dual function in flowering time and shoot determinacy of Arabidopsis
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Data from: The genetic regulation of avian migration timing: combining candidate genes and quantitative genetic approaches in a long-distance migrant
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Mass spectrometry data for: A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
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Data from: Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals
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Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression
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Mimulus cardinalis plasticity analyses and R scripts for: Spatial variation in high temperature-regulated gene expression predicts evolution of plasticity with climate change in the scarlet monkeyflower
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Threshold-dependent gene regulation and partial assortative mating determine wing dimorphism of an Insect
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Data from: Solanum lycopersicum CLASS-II KNOX genes regulate fruit anatomy via gibberellin-dependent and independent pathways
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Regulation of olfactory-based sex behaviors in the silkworm by genes in the sex-determination cascade
<p>Insect courtship and mating depend on integration of olfactory, visual, and tactile cues. Compared to other insects, <em>Bombyx mori</em>, the domesticated silkworm, has relatively simple sexual behaviors as it cannot fly. Here by using CRISPR/Cas9 and electrophysiological techniques we found that courtship and mating behaviors are regulated in male silk moths by mutating genes in the sex determination cascade belonging to two conserved pathways. Loss of <em>Bmdsx</em> gene expression significantly reduced the peripheral perception of the major pheromone component bombykol by reducing expression of the product of the <em>BmOR1</em> gene which completely blocked courtship in adult males. Interestingly, we found that mating behavior was regulated independently by another sexual differentiation gene, <em>Bmfru</em>. Loss of <em>Bmfru</em> completely blocked mating, but males displayed normal courtship behavior. Lack of <em>Bmfru</em> expression significantly reduced the perception of the minor pheromone component bombykal due to the down regulation of <em>BmOR3</em> expression; further, functional analysis revealed that loss of the product of <em>BmOR3</em> played a key role in terminating male mating behavior. Our results suggest that <em>Bmdsx</em> and <em>Bmfru</em> are at the base of the two primary pathways that regulate olfactory-based sexual behavior.</p>
DNA methylation regulates transcription factor specific neurodevelopmental but not sexually dimorphic gene expression dynamics in zebra finch telencephalon
<p>Supplementary Information for the manuscript: "DNA methylation regulates transcription factor specific neurodevelopmental but not sexually dimorphic gene expression dynamics in zebra finch telencephalon"</p>
Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color
<p>The cloning of agriculturally important genes is often complicated by haplotype variation across crop cultivars. Access to pan-genome information greatly facilitates the assessment of structural variations and rapid candidate gene identification. Here, we identified the <i>red glume 1</i> (<i>Rg-B1</i>) gene using association genetics and haplotype analyses in ten reference-grade wheat genomes. Glume color is an important trait to characterize wheat cultivars. Red glumes are frequent among Central European spelt, a dominant wheat subspecies in Europe before the 20<sup>th</sup> century. We used genotyping-by-sequencing to characterize a global diversity panel of 267 spelt accessions, which provided evidence for two independent introductions of spelt into Europe. A single region at the <i>Rg-B1</i> locus on chromosome 1BS was associated with glume color in the diversity panel. Haplotype comparisons across ten high-quality wheat genomes revealed a <i>MYB</i> transcription factor as candidate gene. We found extensive haplotype variation across the ten cultivars, with a particular group of <i>MYB</i> alleles that was conserved in red glume wheat cultivars. Genetic mapping and transient infiltration experiments allowed us to validate this particular <i>MYB</i> transcription factor variants. Our study demonstrates the value of multiple high-quality genomes to rapidly resolve copy number and haplotype variations in regions controlling agriculturally important traits.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.