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990 results for “Hippocampus”
Action potential dependent sIPSCs from 3-4 months old C57BL/6J X SJL female mice hippocampus CA1 pyramidal cell
<p>species : Mus musculus</p> <p>sex : female</p> <p>strain : C57BL/6J X SJL</p> <p>age : 3 - 4 months</p> <p>Voltage-clamp recordings of GABAA spontaneous inhibitory post-synaptic currents (sIPSCs) were obtained from 3-4 months old C57BL/6J X SJL female mice . The dataset contains 701 individual events recorded from 7 different neurons (expB1-B7).</p>
Data from: Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue
<p>Episodic memories comprise diverse attributes of experience distributed across neocortical areas. The hippocampus is integral to rapidly binding these diffuse representations, as they occur, to be later reinstated. However, the nature of the information exchanged during this hippocampal-cortical dialogue remains poorly understood. A recent study has shown that the secondary motor cortex carries two types of representations: place cell-like activity, which were impaired by hippocampal lesions, and responses tied to visuo-tactile cues, which became more pronounced following hippocampal lesions. Using two-photon Ca<sup>2+</sup> imaging to record neuronal activities in the secondary motor cortex of male Thy1-GCaMP6s mice, we assessed the cortical retrieval of spatial and non-spatial attributes from previous explorations in a virtual environment. We show that, following navigation, spontaneous resting state reactivations convey varying degrees of spatial (trajectory sequences) and non-spatial (visuo-tactile attributes) information, while reactivations of non-spatial attributes tend to precede reactivations of spatial representations surrounding hippocampal sharp-wave ripples.</p>
Fig. 3 in A New Pygmy Seahorse (Pisces: Syngnathidae: Hippocampus) from Lord Howe Island
Fig. 3. Hippocampus colemani, this specimen not collected, sex not determined. The single gill
Whole-transcriptome sequencing identifies neuroinflammation, metabolism and blood-brain barrier related processes in the hippocampus of aged mice during perioperative period
<p><span><strong>Aim</strong>:</span><span> Perioperative neurocognitive disorders (PND) occur frequently after surgery and anesthesia, especially in aged patients. Previous studies have shown multiple PND related mechanisms in the hippocampus, however, their relationships remain unclear. Meanwhile, the perioperative neuropathological processes are sophisticated and changeable, single period study could not reveal the accurate mechanisms. Thus, multiperiod whole-transcriptome study is necessary to elucidate the gene expression patterns during perioperative period.</span></p> <p><span><strong>Methods</strong>: </span><span>Aged</span><span> C57BL/6 mice were subjected to exploratory laparotomy under sevoflurane anesthesia. Whole-transcriptome sequencing (RNA-seq analysis) was performed on the hippocampi from control condition (Con), 30 minutes (Day0), 2 days (Day2) and 7 days (Day7) after surgery. Gene Ontology</span><span>/Kyoto Encyclopedia of Genes and Genomes analyses,</span><span> quantitative Real-Time PCR, immunofluorescence and fear conditioning test were also performed to elucidate the pathological processes and modulation networks during the period.</span></p> <p><span><strong>Results</strong>: </span><span>Through RNA-seq analysis, 328, 3597 and 4179 differentially expressed genes (DEGs) were screened out in intraoperative period (Day0 vs Con), early postoperative period (Day2 vs Day0) and late postoperative period (Day7 vs Day2). The involved GO biological processes were divided into 9 categories, and positive-regulated processes were more than negative-regulated ones. Seventy-four transcription factors were highlighted. The potential synaptic and neuroinflammatory pathways were constructed for Neurotransmitter, Synapse and Neuronal alteration categories with 9 DEGs (<em>Htr1a, Rims1, Ezh2,</em> etc.). The metabolic and mitochondrial pathways were constructed for Metabolism, Oxidative stress and Biological rhythm categories with 9 DEGs (<em>Gpld1, Sirt1, Cry2, </em>etc.). The blood-brain barrier and neurotoxicity related pathways were constructed for Blood-brain barrier, Neurotoxicity and Cognitive function categories with 10 DEGs (<em>Mmp2, Itpr1, Nrf1, </em>etc.).</span></p> <p><span><strong>Conclusion</strong>:</span><span> The results revealed gene expression patterns and modulation networks in the aged hippocampus during perioperative period, which provide insights into overall mechanisms and potential therapeutic targets for prevention and treatment of perioperative central nervous system diseases, such as PND, from the genetic level.</span></p>
RNAseq data and analysis results from hippocampus of IVH+ICP, IVH, and sham control rats
<p>Supporting data from the RNAseq experiments appearing in the original manuscript "Sustained ICP Elevation Is a Driver of Spatial Memory Deficits After Intraventricular Hemorrhage and Leads to Activation of Distinct Microglial Signaling Pathways" accepted to Translational Stroke Research on June 24, 2022 (published July 12, 2022). Full experimental and technical details are available at <a href="https://doi.org/10.1007/s12975-022-01061-0">https://doi.org/10.1007/s12975-022-01061-0</a>. </p>
Cross-modal representation of identity in primate hippocampus
<p>Faces and voices are the dominant social signals used to recognize individuals amongst human and nonhuman primates. Yet, evidence that information across these signals can be integrated into a modality-independent representation of individual identity in the primate brain has been reported only in human patients. Here we show that, like humans, single neurons in the marmoset monkey hippocampus exhibit invariant neural responses when presented with the faces or voices of specific individuals. However, we also identified a population of single neurons in hippocampus that was responsive to the cross-modal identity of multiple conspecifics, not only a single individual. An identity network model revealed population-level, cross-modal representations of individuals in hippocampus, underscoring the broader contributions of many neurons to encode identity. This pattern was further evidenced by manifold projections of population activity which likewise showed separability of individuals, as well as clustering for family members, suggesting that multiple learned social categories are encoded as related dimensions of identity in hippocampus. The constellation of findings presented here reveals a novel perspective on the neural basis of identity representations in primate hippocampus as being both invariant to modality and comprising multiple levels of acquired social knowledge.</p>
COMPUTING HUBS IN THE HIPPOCAMPUS AND CORTEX
<p><strong>Neural computation, which relies on the active storage and sharing of information, occurs within large neuron networks in the highly dynamic context of varying brain states. Whether such functions are performed by specific </strong><strong>sub</strong><strong>sets of neurons and whether they occur in specific dynamical regimes remain</strong><strong>s</strong><strong> poorly understood. Using high density recordings in the hippocampus, medial entorhinal and medial prefrontal cortex of the rat, we identify computing </strong><strong>sub</strong><strong>states, or </strong><strong>discrete </strong><strong>epochs, in which specific computing hub neurons perform well defined storage and sharing operations in a brain state-dependent manner. We retrieve a multiplicity of distinct computing </strong><strong>sub</strong><strong>states within each global brain state, such as REM and nonREM sleep. Half of recorded neurons act as computing hubs in at least one </strong><strong>sub</strong><strong>state, suggesting that functional roles are not firmly hardwired but dynamically reassigned at the second timescale. We identify sequences of </strong><strong>sub</strong><strong>states whose temporal organization is dynamic and stands between order and disorder. We propose that global brain states constrain the language of neuronal computations by regulating the syntactic complexity of these </strong><strong>sub</strong><strong>state sequences.</strong></p>
Simultaneous single-unit recording from the basal amygdala and dorsal hippocampus
<p>Animals seeking survival needs must be able to assess different locations of threats in their habitat. However, the neural integration of spatial and risk information essential for guiding goal-directed behavior remains poorly understood. Thus, we investigated simultaneous activities of fear-responsive basal amygdala (BA) and place-responsive dorsal hippocampus (dHPC) neurons as rats left the safe nest to search for food in an exposed space and encountered a simulated 'predator.' In this realistic situation, BA cells increased their firing rates and dHPC place cells decreased their spatial stability near the threat. Importantly, only those dHPC cells synchronized with the predator-responsive BA cells remapped significantly as a function of escalating risk location. Moreover, optogenetic stimulation of BA neurons was sufficient to cause spatial avoidance behavior and disrupt place fields. These results suggest a dynamic interaction of BA's fear signaling cells and dHPC's spatial coding cells as animals traverse safe-danger areas of their environment.</p>
Automated and manual segmentation of the hippocampus in human infants
<p>The hippocampus, critical for learning and memory, undergoes substantial changes early in life. Investigating the developmental trajectory of hippocampal structure and function requires an accurate method for segmenting this region from anatomical MRI scans. Although manual segmentation is regarded as the "gold standard" approach, it is laborious and subjective. This has fueled the pursuit of automated segmentation methods in adults. However, little is known about the reliability of these automated protocols in infants, particularly when anatomical scan quality is degraded by head motion or the use of shorter and quieter infant-friendly sequences. During a task-based fMRI protocol, we collected quiet T1-weighted anatomical scans from 42 sessions with awake infants aged 4–23 months. Two expert tracers first segmented the hippocampus in both hemispheres manually. The resulting inter-rater reliability (IRR) was only moderate, reflecting the difficulty of infant segmentation. We then used four protocols to predict these manual segmentations: average adult template, average infanBt template, FreeSurfer software, and Automated Segmentation of Hippocampal Subfields (ASHS) software. ASHS generated the most reliable hippocampal segmentations in infants, exceeding the manual IRR of experts. Automated methods thus provide robust hippocampal segmentations of noisy T1-weighted infant scans, opening new possibilities for interrogating early hippocampal development.</p>
Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus: electrophysiology data
<p>This publication contains the recording data of the electrophysiology section of the manuscript entitled<strong> Erythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus</strong>. Files are organized as follows:</p> <ul> <li>Raw_LFP.zip contains the raw local field potential (LFP) recordings of mice's dorsal hippocampus (CA1), under head-fix recording set up using Open Ephys GUI.</li> <li>README.txt file contains de information about the codification data of mice.</li> </ul> <p>Matlab and R scripts used for data processing are available upon request</p>
Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
ClinicalTrials.gov study NCT01227954. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Long-term Transverse Imaging of the Hippocampus with Glass Microperiscopes
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Automated and manual segmentation of the hippocampus in human infants
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Data from: Cortical reactivation of spatial and non-spatial features coordinates with hippocampus to form a memory dialogue
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Simultaneous single-unit recording from the basal amygdala and dorsal hippocampus
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Data from: Evolution of cellular architecture and function of the hippocampus: Insights from the artificial selection experiment
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Whole-transcriptome sequencing identifies neuroinflammation, metabolism and blood-brain barrier related processes in the hippocampus of aged mice during perioperative period
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Data from: Spatial encoding in primate hippocampus during free navigation
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Cross-modal representation of identity in primate hippocampus
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Inhibitory plasticity supports replay generalization in the hippocampus
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.