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datasets available to search
ShareScore release 0.9.0
Dataset results
52 results for “Immune repertoire”
Impact of immune repertoire in Muscle – Invasive Bladder Cancer (MIBC) on predicting response and survival after neoadjuvant cisplatin-based chemotherapy (NAC)
GEO Series GSE247185. Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing.
Global expression profiling of peripheral Qa-1 class Ib-restricted CD8aa+TCRab+ regulatory T Cells reveals innate-like features: implications for immune regulatory repertoire
GEO Series GSE22985. Mus musculus. 6 samples. Type: Expression profiling by array.
Monitoring the Efficacy of Duvalizumab Combined With Neoadjuvant Chemotherapy for Ib-IIIb NSCLC by Sequencing of Immune Receptor Repertoire: a Prospective, One Arm Clinical Study
ClinicalTrials.gov study NCT04897386. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Molecule template estimation using Validator Barcodes as an alternative to UMIs in multiplex PCR for adaptive immune repertoire profiling
GEO Series GSE297422. Mus musculus; Homo sapiens. 18 samples. Type: Other.
Polymorphic immune mechanisms regulate commensal repertoire
GEO Series GSE136572. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
Longer read lengths are required for RNA velocity analysis of single-cell RNA-sequencing with paired immune repertoire and transcriptome profiling
GEO Series GSE169657. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Investigation of corneal limbal stem cells and immune repertoires in human infant cornea by multi-omics solution
GEO Series GSE230439. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Age-related dynamics and spectral characteristics of the TCRβ repertoire in healthy children: implications for immune aging
<p><strong><span>Background: </span></strong><span>The T cell receptor (TCR) is crucial for adaptive immunity, providing a diverse repertoire for antigen response. However, despite its clinical importance, baseline characterization of the TCR in the pediatric population remains limited.</span></p> <p><strong><span>Methods:</span></strong><span> We conducted TCR<span>β</span> sequencing on 325 healthy Chinese children aged 0-18 years, categorized into six age groups, to understand dynamic changes and establish a reference database of TCR<span>β</span> rearrangements for this demographic. Furthermore, we used cell sorting on 81 samples with flow cytometry to analyze cellular composition and associations, focusing specifically on age-related variations in the TCRβ repertoire.</span></p> <p><strong><span>Results: </span></strong><span>Our study revealed an age-related decline in TCRβ repertoire diversity, marked by increased high-frequency and in-frame clonotypes. This shift in diversity is likely due to age-related variations in CDR3 length and V(D)J gene usage. The analysis of dynamic clonal changes in TCRβ, especially in public clones, suggests a link to perinatal influences and the immune system's evolving personalization. Early-life vaccinations and antigen exposures play a pivotal role in shaping this immune evolution. Notably, a significant association was found between the decrease of CD4<sup>+</sup> T naive cells and the diminishing TCRβ repertoire diversity along with age. Furthermore, our predictive models highlight specific TCRβ features as potential biomarkers for biological age, supported by their significant correlation.</span></p> <p><strong><span>Conclusion: </span></strong><span>This study provides essential insights into age-related variations in the TCRβ repertoire among children, enriching our understanding of pediatric immune system evolution and informing potential disease prevention strategies.</span></p>
Compartment size and proliferation shape the murine T cell receptor repertoire in splenic T- and B cell zones during an immune response
GEO Series GSE293228. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia
<p>Data to reproduce findings in the manuscript "Single-cell transcriptomics identifies synergistic role of leukemic and non-leukemic immune repertoires in CD8+ T-cell Large Granular Lymphocytic Leukemia". <br> <br> The folder contains:</p> <p>1) Processed scRNA+TCRab-seq data in a Seurat-folder, including </p> <p>* Object with 11 T-LGLL samples and 6 healthy samples<br> * Object with only hyperexpanded (>= 10 TCRs) T-cells from all T-LGLL samples and 6 healthy samples<br> * Object with only T-LGLL clones from 11 T-LGLL samples<br> * Object with non-leukemic repertoires from 11 T-LGLL samples, 6 healthy samples, 4 CML samples, 4 CLL samples, 2 RCC samples, and 1 NSCLC sample</p> <p><br> 2) TCRb-seq samples from CD8+ sorted peripheral blood samples from patients with CD8+ T-LGLL </p> <p>Please see manuscript and Github for further details.</p>
VH repertoires from 19 adults immunized with Tdap, at baseline or at day 7
Open the record for dataset details and reuse information.
Integrated analysis of mRNAs and lncRNAs repertoires involved immune response in panleukopenia virus-infected feline kidney cell line
GEO Series GSE137896. Felis catus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.