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Dataset results
460 results for “Immunoglobulin A”
Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease
ClinicalTrials.gov study NCT00288600. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Treatment of Chronic Immune Thrombocytopenic Purpura (ITP) With Intravenous Immunoglobulin IgPro10
ClinicalTrials.gov study NCT00168038. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Study of ALXN2050 in Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)
ClinicalTrials.gov study NCT05097989. IPD Sharing: UNDECIDED. Countries: 16. Publications: 2.
Strategic Help With Immunoglobulin to Enhance Protect Against Late Disease (CMV)
ClinicalTrials.gov study NCT06958796. IPD Sharing: YES. Countries: 1. Publications: 4.
Infliximab Plus Intravenous Immunoglobulin for the Primary Treatment of Kawasaki Disease
ClinicalTrials.gov study NCT00760435. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Study to Evaluate the Safety, Tolerability of BCX9930 in Participants With Either Complement 3 Glomerulopathy (C3G), Immunoglobulin A Nephropathy (IgAN), or Primary Membranous Nephropathy (PMN)
ClinicalTrials.gov study NCT05162066. IPD Sharing: NO. Countries: 4. Publications: 1.
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy
ClinicalTrials.gov study NCT03608033. IPD Sharing: NO. Countries: 23. Publications: 2.
The Efficacy Of Intravenous Immunoglobulin Therapy In Treatment Induced Neuropathy Of Diabetes
ClinicalTrials.gov study NCT02915263. IPD Sharing: NO. Countries: 1. Publications: 22.
Efficacy and Safety of Nefecon in Patients With Primary IgA (Immunoglobulin A) Nephropathy
ClinicalTrials.gov study NCT03643965. IPD Sharing: NO. Countries: 19. Publications: 5.
Efficacy and Safety of Viaskin Peanut in Children With Immunoglobulin E (IgE)-Mediated Peanut Allergy
ClinicalTrials.gov study NCT02636699. IPD Sharing: Not stated. Countries: 5. Publications: 4.
Role of Immunoglobulin E (IgE) Bearing Cells in Chronic Idiopathic Urticaria (CIU)
ClinicalTrials.gov study NCT03111628. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS).
ClinicalTrials.gov study NCT02525874. IPD Sharing: Not stated. Countries: 7. Publications: 1.
Study of Subcutaneous Immunoglobulin in Patients With PID Requiring IgG Replacement Therapy
ClinicalTrials.gov study NCT00419341. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluating the Effectiveness of Intravenous Immunoglobulin Therapy in Autoimmune Autonomic Ganglionopathy
ClinicalTrials.gov study NCT01522235. IPD Sharing: YES. Countries: 1. Publications: 29.
Data from: Anti-HLA antibodies may be a subset of polyreactive immunoglobulins generated after viral superinfection
Open the record for dataset details and reuse information.
Maternal effects and urbanization: Variation of yolk androgens and immunoglobulin in city and forest blackbirds
<p>Wildlife inhabiting urban environments exhibit drastic changes in morphology, physiology and behaviour. It has often been argued that these phenotypic responses could be the result of micro-evolutionary changes following the urbanization process. However, other mechanisms such as phenotypic plasticity, maternal effects and developmental plasticity could be involved as well. To address maternal effects as potential mechanisms, we compared maternal hormone and antibody concentrations in eggs between city and forest populations of European blackbirds (<i>Turdus merula</i>), a widely distributed species for which previous research demonstrated differences in behavioural and physiological traits. We measured egg and yolk mass, yolk concentrations of androgens (androstenedione (A<sub>4</sub>), testosterone (T), 5α-dihydrotestosterone (5α-DHT), and immunoglobulins (IgY) and related them to population, clutch size, laying order, embryo sex, and progress of breeding season. We show: i) earlier onset of laying in the city than forest population, but similar egg and clutch size; ii) higher overall yolk androgen concentrations in the forest than the city population (sex-dependent for T); iii) greater among-female variation of yolk T and 5α-DHT concentrations in the forest than city population, but similar within-clutch variation; iv) similar IgY concentrations with a seasonal decline in both populations; and v) population-specific positive (city) or negative (forest) association of yolk A<sub>4</sub> and T with IgY concentrations. Our results are consistent with the hypotheses that hormone-mediated maternal effects contribute to differences in behavioural and physiological traits between city and forest individuals and that yolk androgen and immunoglobulin levels can exhibit population-specific relationships rather than tradeoff against each other. </p>
All-atom accelerated molecular dynamics (aMD) simulations of Filamin-A (FLNa) actin-binding Domain, immunoglobulin-like Domains 3, 4, 5, 21 and 24 to investagate the impact of known missense mutations associated with periventricular nodular heterotopia in the liveborn males
<p>Data includes all of the wild-type and mutant trajectories of accelerated all-atom molecular dynamics (aMD) simulations of Filamin-A (FLNa, the product of <em>FLNA</em> gene located on chromosome X). Wild-type proteins are from the PDB structures with IDs: 4M9P, 3HOP, 3CNK. The mutations, including R484Q that we discovered in a Turkish family, were formerly found in the liveborn males with <em>FLNA</em>-associated periventricular nodular heterotopia (PNH), who survived with the only copy of mutated <em>FLNA</em>. To understand how these mutations lead to the PNH and simultaneously allow their survival, we performed these MD simulations for the wild-type and mutant systems.</p> <p>Systems were prepared in Visual Molecular Dynamics (VMD 1.9.3) by placing them in a TIP3P water box with approximately 20 Å thickness from the protein surface and neutralizing the system by adding counter ions in the form of NaCl. Of note, only protein parts were kept for the submission to reduce the size of files. Nanoscale Molecular Dynamics (NAMD 2.13-CUDA) was used to perform MD simulations with CHARMM36m force field. For pressure and temperature controls, Nosé-Hoover Langevin barostat and Langevin thermostat were used. ShakeH algorithm of NAMD was applied for water molecule constraints. 12 Å cut-off distance was used for van der Waals interactions. Switching function starts at 10 Å and reaches zero at 14 Å. Integration time-step was 2 fs. To compute the long-range Coulomb interactions, the particle-mash Ewald method was used. After a 10000-step minimization with conjugate gradient algorithm and an equilibration for 1 ns at 298 K under NVT ensemble, production simulations were run along 100 ns. Only the production simulations were supplied in this dataset. Further details are available in the regarding configuration files.</p> <p>Resulting analysis files and scripts are included with the carbon alpha-containing dcd files of the simulations.</p> <p>This dataset is not used directly for any study, but they are preliminary results for the usage of aMD to understand rare disease mechanisms.</p> <p>Related publications:</p> <pre>Zenodo repo of classical MD for these variants: https://doi.org/10.5281/zenodo.4483108</pre> <p>Journal article based on classical MD:</p> <p>Gerlevik U, Saygı C, Cangül H, Kutlu A, Çaralan EF, Topçu Y, et al. (2022) Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia. PLoS ONE 17(5): e0265400. https://doi.org/10.1371/journal.pone.0265400</p>
Figure S1: Two-tailed intergroup Pearson analysis between patient age, COVID-19 detection, de-livery time, gravida, and termination week (Y-axis) with maternal and neonatal anti-COVID-19 immunoglobulins (IgG and IgM) (X-axis), depicted as a three-point color map (lowest = blue, 0 = white, highest = red) showed no significant correlation (at p>0.05).
<p>Figure S1: Two-tailed intergroup Pearson analysis between patient age, COVID-19 detection, de-livery time, gravida, and termination week (Y-axis) with maternal and neonatal anti-COVID-19 immunoglobulins (IgG and IgM) (X-axis), depicted as a three-point color map (lowest = blue, 0 = white, highest = red) showed no significant correlation (at p>0.05).</p>
Figure 3 in Variation in leukocyte indices and immunoglobulin levels according to host density, sex, flea burden and tularemia prevalence in the common vole Microtus arvalis
Figure 3: Relationships between the proportion of eosinophils and a) vole density (number of captured voles/100 traps/24 h), and b) tularemia and flea prevalence in voles. The grey shaded area shows the 95 % confidence intervals of the predicted curve (a; left) and error bars show standard deviations (b; right).
Figure 2 in Variation in leukocyte indices and immunoglobulin levels according to host density, sex, flea burden and tularemia prevalence in the common vole Microtus arvalis
Figure 2: Relationship between the neutrophil-to-lymphocyte (N:L) ratio and vole density index according to sex. Vole density was estimated as the number of captured voles/100 traps/24 h. Grey shaded areas show the 95 % confidence intervals of the predicted curves.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.