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186
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ShareScore release 0.9.0
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186 results for “Insulin secretion”
Rapid Effects of Hydrocortisone on Glucose-induced Insulin Secretion in Healthy Humans
ClinicalTrials.gov study NCT00709839. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Liraglutide on Pulsatile Insulin Secretion in Subjects With Type 2 Diabetes
ClinicalTrials.gov study NCT01507311. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Taking a Single Tablet of Iron on Insulin Secretion
ClinicalTrials.gov study NCT05238987. IPD Sharing: NO. Countries: 1. Publications: 22.
Supplementary tables for Low-density lipoprotein cholesterol is associated with insulin secretion
Open the record for dataset details and reuse information.
Thiazides attenuate insulin secretion through inhibition of mitochondrial carbonic anhydrase 5b in β-islet cells in mice
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PDX1-/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin-secreting cells
<p>PDX1-/NKX6.1+ progenitors derived from hESCs were differentiated to pancreatic beta cell stage where they generated glucose-responsive, insulin-secreting cells. The transcriptome profile of hESC- derived PDX1-/NKX6.1+ progenitors were compared with hPSC-derived PDX1+/NKX6.1+ pancreatic progenitors as described in the article entitled "<strong>PDX1<sup>-</sup>/NKX6.1<sup>+</sup>progenitors derived from human pluripotent stem cells as a novel source of insulin-secreting cells</strong>" by Memon et al. 2020. Furthermore, beta cells derived from PDX1-/NKX6.1+ progenitors (3D-beta) were compared with their own endocrine progenitors at an earlier stage (stage 5, 3D-S5) to map their development. </p> <p>The file name is : Sample name_replicate_sample ID_read direction_001 where:</p> <p>-3D-beta: insulin-expressing cells derived from self-detached, 3D, PDX1-/NKX6.1+ progenitors</p> <p>-3D-S5: endocrine progenitors from stage 5, derived from self-detached, 3D, PDX1-/NKX6.1+ progenitors</p> <p>- RNA-seq data were generated from two biological replicates in most cases.</p> <p>- Read direction: R1 (Forward), R2 (Reverse).</p>
Data from: The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults
Although mutations in HNF4A were identified as the cause of Maturity Onset Diabetes of the Young 1 (MODY1) two decades ago, the mechanisms by which this nuclear receptor regulates glucose homeostasis remain unclear. Here we report that loss of Drosophila HNF4 recapitulates hallmark symptoms of MODY1, including adult-onset hyperglycemia, glucose intolerance and impaired glucose-stimulated insulin secretion (GSIS). These defects are linked to a role for dHNF4 in promoting mitochondrial function as well as the expression of Hex-C, a homolog of the MODY2 gene Glucokinase. dHNF4 is required in the fat body and insulin-producing cells to maintain glucose homeostasis by supporting a developmental switch toward oxidative phosphorylation and GSIS at the transition to adulthood. These findings establish an animal model for MODY1 and define a developmental reprogramming of metabolism to support the energetic needs of the mature animal.
Data from: Cephalic phase of insulin secretion in response to a meal is unrelated to family history of Type 2 diabetes
The pre-absorptive cephalic phase of insulin secretion is elicited during the first ten min of a meal and before glucose levels rise. Its importance for insulin release during the post-absorptive phase has been well documented in animals but its presence or importance in man has become increasingly controversial. We here examined the presence of an early cephalic phase of insulin release in 31 well matched individuals without (n=15) or with (n=16) a known family history of type 2 diabetes (first-degree relatives; FDR). We also examined the potential differences in individuals with or without impaired fasting (IFG) and impaired glucose tolerance (IGT). We here demonstrate that a cephalic phase of insulin secretion was present in all individuals examined and without any differences between control persons and FDR or IFG/IGT. However, the overall importance of the cephalic phase is conjectural since it was unrelated to the subsequent post-absorptive insulin release or glucose tolerance. One of the best predictors of the incremental cephalic phase of insulin release was fasting insulin level and, thus, a relation to degree of insulin sensitivity is likely. In conclusion, an early pre-absorptive and cephalic phase of insulin release is robustly present in man. However, we could not document any relation to family history of Type 2 diabetes nor to the post-absorptive phase and, thus, confirm its importance for subsequent degree of insulin release or glucose tolerance.
Effect of Momordica Charantia Administration on Type 2 Diabetes Mellitus, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT02397447. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Oral Glucose Tolerance Test
ClinicalTrials.gov study NCT04958109. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Glucagon on Fasting Insulin Secretion and Glucose Metabolism in Subjects Without Type 2 Diabetes
ClinicalTrials.gov study NCT06424106. IPD Sharing: YES. Countries: 1. Publications: 0.
Contribution of Pancreatic αcells Function to Blood Glucose Regulation in Chinese Type 2 Diabetics- the Effect of Sitagliptin on Glucagon Secretion, Insulin Secretion and Insulin Resistance in Chinese
ClinicalTrials.gov study NCT01610154. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Effect of Vildagliptin on the Maximum Insulin Secretion in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT00351585. IPD Sharing: Not stated. Countries: 0. Publications: 1.
KP-10 and Insulin Secretion in Men
ClinicalTrials.gov study NCT03771326. IPD Sharing: UNDECIDED. Countries: 0. Publications: 2.
Effect of Dapagliflozin on Insulin Secretion and Insulin Sensitivity in Patients With Prediabetes
ClinicalTrials.gov study NCT02700334. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Nexium and Probiotics on Insulin Secretion and Cardiovascular Risk Factors in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT00699426. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Extra Virgin Olive Oil on Glycemic Control ,Insulin Resistance and Insulin Secretion
ClinicalTrials.gov study NCT03891927. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Effect of Irvingia Gabonensis Administration on Metabolic Syndrome, Insulin Secretion and Insulin Sensitivity
ClinicalTrials.gov study NCT02354339. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Artemisia Dracunculus on Glucose Intolerance, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT02330341. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Dose-response Study Examining the Contribution of GLP-1 Receptor Signaling to Glucagon-stimulated Insulin Secretion
ClinicalTrials.gov study NCT04459338. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.