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Dataset results
105 results for “Longitudinal assessment”
Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis
ClinicalTrials.gov study NCT04141410. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HDHQ150/Q150 mouse model of Huntington's disease
A variety of mouse models have been developed that express mutant huntingtin (mHTT) leading to aggregates and inclusions that model the molecular pathology observed in Huntington's disease. Here we show that although homozygous HdhQ150 knock-in mice developed motor impairments (rotarod, locomotor activity, grip strength) by 36 weeks of age, cognitive dysfunction (swimming T maze, fear conditioning, odor discrimination, social interaction) was not evident by 94 weeks. Concomitant to behavioral assessments, T2-weighted MRI volume measurements indicated a slower striatal growth with a significant difference between wild type (WT) and HdhQ150 mice being present even at 15 weeks. Indeed, MRI indicated significant volumetric changes prior to the emergence of the "clinical horizon" of motor impairments at 36 weeks of age. A striatal decrease of 27% was observed over 94 weeks with cortex (12%) and hippocampus (21%) also indicating significant atrophy. A hypothesis-free analysis using tensor-based morphometry highlighted further regions undergoing atrophy by contrasting brain growth and regional neurodegeneration. Histology revealed the widespread presence of mHTT aggregates and cellular inclusions. However, there was little evidence of correlations between these outcome measures, potentially indicating that other factors are important in the causal cascade linking the molecular pathology to the emergence of behavioral impairments. In conclusion, the HdhQ150 mouse model replicates many aspects of the human condition, including an extended pre-manifest period prior to the emergence of motor impairments.
Longitudinal Assessment of Cardiovascular and Renal Health in Patients With Hepatitis-C (CARE-Hep C)
ClinicalTrials.gov study NCT01846494. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Longitudinal Assessment of Children With Severe Asthma and Severe Pre-school Wheeze
ClinicalTrials.gov study NCT01982162. IPD Sharing: Not stated. Countries: 0. Publications: 6.
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
ClinicalTrials.gov study NCT07258615. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Longitudinal Assessment of Adults With Severe Asthma
ClinicalTrials.gov study NCT01976767. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Longitudinal Pulmonary Chronic Graft-versus-host-disease (GvHD) Assessment in Hematopoietic Stem Cell Transplantation (HSCT) Patients
ClinicalTrials.gov study NCT07297303. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the HDHQ150/Q150 mouse model of Huntington's disease
Open the record for dataset details and reuse information.
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
GEO Series GSE133509. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Cancer avatars derived from genetically engineered pluripotent stem cells allow for longitudinal assessment of tumor development
GEO Series GSE133479. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Longitudinal Assessment of Atypical Tripeptidyl Peptidase 1 Enzyme Deficiency Patients
ClinicalTrials.gov study NCT04098211. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Longitudinal MRI Assessment in Patients With Diffuse Low-grade Gliomas
ClinicalTrials.gov study NCT04346472. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Longitudinal Assessment of Arthralgia and Related Symptoms in Breast Cancer Patients Receiving Aromatase Inhibitors
ClinicalTrials.gov study NCT00738998. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Longitudinal Assessment of Post-concussion Driving in Young Adults
ClinicalTrials.gov study NCT05942638. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Determining Postoperative Recovery and the Impact of Adverse Events in Neurosurgery Based on Self-reported, App-based Longitudinal Assessment - a Collaborative Observational Research Project
ClinicalTrials.gov study NCT06352710. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Longitudinal Assessment of Multiple Organs in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT04114682. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Longitudinal Assessment of Maximal Inspiratory Pressure and Functional Capacity Following Inspiratory Muscle Training in Frail Older Adults (IMT-2)
ClinicalTrials.gov study NCT07328334. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Longitudinal Assessment of Biomarkers After Oesophagogastric Cancer Surgery
ClinicalTrials.gov study NCT06289374. IPD Sharing: NO. Countries: 1. Publications: 0.
Assessing AlloSure Dd-cfDNA Monitoring Insights of Renal Allografts With Longitudinal Surveillance
ClinicalTrials.gov study NCT04566055. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Evaluation of Autonomic, Imaging and Genetic Markers for Parkinson-related Dementia : Longitudinal Assessment of a PD Cohort.
ClinicalTrials.gov study NCT06156917. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.