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141 results for “Metabolic Interactions”
This Study Tests the Effect of Risankizumab on the Metabolism in the Liver of Five Additional Drugs to Study Possible Drug Interactions in Patients With Psoriasis With or Without Psoriatic Arthritis
ClinicalTrials.gov study NCT02772601. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Cross-sectional Study on IBS Subtypes, Chinese Medicine Pattern and Host-gut Microbiota Metabolic Interactions
ClinicalTrials.gov study NCT02822677. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Temperature and predator cues interactively affect ontogenetic metabolic scaling of aquatic amphipods
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Interaction between the TCF7L2 gene and dietary intake on metabolic syndrome risk factors among Saudi Arabian adults
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Data from: Uncovering key metabolic determinants of the drug interactions between trimethoprim and erythromycin in Escherichia coli
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Data from: Energy demand and the context-dependent effects of genetic interactions underlying metabolism
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Large-scale metabolic interaction network of the mouse and human gut microbiota
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Intraspecific interaction of host plants leads to concentrated distribution of a specialist herbivore through metabolic alterations in the leaves
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Interactions between metabolism and growth can determine the co-existence of Staphylococcus aureus and Pseudomonas aeruginosa
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Membrane lipid metabolism, heat shock response, and energy costs mediate the interaction between acclimatization and heat hardening response
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Data from: Impacts of deforestation-induced warming on the metabolism, growth, and trophic interactions of an afrotropical stream fish
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Interactive effects of elevated temperature and drought on plant carbon metabolism: A meta‐analysis
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Metabolic phenotype mediates the outcome of competitive interactions in a response-surface field experiment
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Metabolic rate interacts with resource availability to determine individual variation in microhabitat use in the wild
<p class="MsoNoSpacing">Ecological pressures such as competition can lead individuals within a population to partition resources or habitats, but the underlying intrinsic mechanisms that determine an individual's resource use are not well understood. Here we show that an individual's own energy demand and associated competitive ability influence its resource use, but only when food is more limiting. We tested whether intraspecific variation in metabolic rate leads to microhabitat partitioning among juvenile Atlantic salmon (<i>Salmo salar</i>) in natural streams subjected to manipulated nutrient levels and subsequent <i>per capita</i> food availability. We found that individual salmon from families with a higher baseline (standard) metabolic rate (which is associated with greater competitive ability) tended to occupy faster flowing water, but only in streams with lower <i>per capita</i> food availability. Faster flowing microhabitats yield more food, but high metabolic rate fish only benefited from faster growth in streams with high food levels, presumably because in low food environments the cost of a high metabolism offset the benefits of acquiring a productive microhabitat. The benefits of a given metabolic rate were thus context-dependent. These results demonstrate that intraspecific variation in metabolic rate can interact with resource availability to determine the spatial structuring of wild populations.</p>
Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness
<p>In animals with distinct life stages such as holometabolous insects, adult phenotypic variation is often shaped by the environment of immature stages, including their interactions with microbes colonizing larval habitats. Such carry-over effects were previously observed for several adult traits of the mosquito <i>Aedes aegypti</i> after larval exposure to different bacteria, but the mechanistic underpinnings are unknown. Here, we investigated the molecular changes triggered by gnotobiotic larval exposure to different bacteria in <i>Ae. aegypti</i>. We initially screened a panel of 16 bacterial isolates from natural mosquito breeding sites to determine their ability to influence adult life-history traits. We subsequently focused on four bacterial isolates (belonging to <i>Flavobacterium</i>, <i>Lysobacter</i>, <i>Paenibacillus</i>, and <i>Enterobacteriaceae</i>) with significant carry-over effects on adult survival and found that they were associated with distinct transcriptomic profiles throughout mosquito development. Moreover, we detected carry-over effects at the level of gene expression for the <i>Flavobacterium</i> and <i>Paenibacillus</i> isolates. The most prominent transcriptomic changes in gnotobiotic larvae reflected a profound remodeling of lipid metabolism, which translated into phenotypic differences in lipid storage and starvation resistance at the adult stage. Together, our findings indicate that larval exposure to environmental bacteria trigger substantial physiological changes that impact adult fitness, uncovering a possible mechanism underlying carry-over effects of mosquito-bacteria interactions during larval development.</p>
Drug Drug Interaction Trial With Strong CYP3A4 Inhibitor (Itraconazole) in CYP2C19 Extensive Metabolizers and Poor Metabolizers
ClinicalTrials.gov study NCT02248259. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults
ClinicalTrials.gov study NCT05995249. IPD Sharing: YES. Countries: 1. Publications: 0.
The Interaction Between Diabetes and Estradiol on Human Brain Metabolism in Postmenopausal Women
ClinicalTrials.gov study NCT03681691. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Drug Interaction Study to Assess the Effect of LY317615 on the Metabolic Pathway of Warfarin
ClinicalTrials.gov study NCT01388335. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Drug Interaction Study to Assess the Effect of LY2603618 on the Metabolic Pathway of Desipramine
ClinicalTrials.gov study NCT01358968. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.