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52 results for “Microbial control”
Glucose competition between immune cells and microbial pathogens controls infections
GEO Series GSE99904. Candida albicans; Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Data from: Top-down control of carbon sequestration: grazing affects microbial structure and function in salt marsh soils
Tidal wetlands have been increasingly recognized as long-term carbon sinks in recent years. Work on carbon sequestration and decomposition processes in tidal wetlands focused so far mainly on effects of global-change factors such as sea-level rise and increasing temperatures. However, little is known about effects of land use, such as livestock grazing, on organic matter decomposition and ultimately carbon sequestration. The present work aims at understanding the mechanisms by which large herbivores can affect organic matter decomposition in tidal wetlands. This was achieved by studying both direct animal-microbe interactions and indirect animal-plant-microbe interactions in grazed and ungrazed areas of two long-term experimental field sites at the German North Sea coast. We assessed bacterial and fungal gene abundance using quantitative PCR, as well as the activity of microbial exo-enzymes by conducting fluorometric assays. We demonstrate that grazing can have a profound impact on the microbial community structure of tidal wetland soils, by consistently increasing the fungi-to-bacteria ratio by 38-42%, and therefore potentially exerts important control over carbon turnover and sequestration. The observed shift in the microbial community was primarily driven by organic matter source, with higher contributions of recalcitrant autochthonous (terrestrial) vs. easily degradable allochthonous (marine) sources in grazed areas favoring relative fungal abundance. We propose a novel and indirect form of animal-plant-microbe interaction: top-down control of aboveground vegetation structure determines the capacity of allochthonous organic matter trapping during flooding and thus the structure of the microbial community. Furthermore, our data provide the first evidence that grazing slows down microbial exo-enzyme activity and thus decomposition through changes in soil redox chemistry. Activities of enzymes involved in C cycling were reduced by 28-40%, while activities of enzymes involved in N cycling were not consistently affected by grazing. It remains unclear if this is a trampling-driven direct grazing effect, as hypothesized in earlier studies, or if the effect on redox chemistry is plant mediated and thus indirect. This study improves our process-level understanding of how grazing can affect the microbial ecology and biogeochemistry of semi-terrestrial ecosystems that may help explain and predict differences in C turnover and sequestration rates between grazed and ungrazed systems.
Data from: The vertical distribution and control of microbial necromass carbon in forest soils
<p><span><b>Aim:</b> Forest soils contain large amounts of terrestrial organic carbon (C), but the formation pathway of soil organic C (SOC) remains unclear. Recent evidence suggests that microbial necromass is a significant source of SOC, yet a global quantitative assessment across the whole-soil profile is lacking. We aimed to assess the vertical distribution and control of microbial-derived SOC in forest soils.</span></p> <p><span><b>Location:</b> Global forests.</span></p> <p><span><b>Time period:</b> 1996-2019.</span></p> <p><span><b>Major taxa studied:</b> Soil microbial necromass carbon.</span></p> <p><span><b>Methods:</b> We evaluated the proportions of fungal and bacterial necromass C in total SOC in the litter layer, O horizon soil, and various depths of mineral soil in forests using microbial biomarker (glucosamine and muramic acid) data.</span></p> <p><span><b>Results:</b> The total microbial necromass C increased significantly with soil depth, ranging from 30% of SOC in O horizon soil to 62% of SOC in mineral soils below 50 cm. However, only bacterial necromass C followed this increasing trend with soil depth; fungal necromass C showed little variation across the whole-soil profile. Higher fungal and bacterial necromass C was observed in soils with lower C/N ratios and smaller aggregate sizes. Soil C/N ratio and microbial biomass C dominantly determined microbial necromass C in surface soil (above 20 cm), but soil clay content was the primary factor in subsoil (below 20 cm).</span></p> <p><span><b>Main conclusions: </b>Microbial necromass C accounted for high percentages of the total SOC in forest soils (particularly at depths >20 cm), but its long-term stabilization may be governed by different mechanisms at different soil horizons. Substrate quality regulates microbial activity and then controls biomass turnover in surface soil, while aggregate occlusion could facilitate mineral protection of microbial necromass C in subsoil. These differential controls of microbial-derived organic C could be applied in Earth system studies for predicting soil organic C dynamics in forests.</span></p>
A Randomised Controlled Clinical Trial on the Use of a Dental Aerosol Box to Prevent Microbial Transmission During Dental Procedure
ClinicalTrials.gov study NCT05034705. IPD Sharing: NO. Countries: 1. Publications: 0.
The BEGIN Study Bifidobacterium Infantis to Newborns: Effects of Modulating the Gut Microbial Composition on Growth, Immune Function and Inflammatory Conditions - a Randomized Placebo-controlled Doubl
ClinicalTrials.gov study NCT06452199. IPD Sharing: YES. Countries: 1. Publications: 0.
A Phase 2, Open-Label, Randomized, Parallel Group, Placebo-Controlled, Single-Center Study to Assess Anti-microbial Efficacy and Safety of DCN01 Compared to Unisol® Following Topical Periocular Admini
ClinicalTrials.gov study NCT01853722. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Reconciling multiple impacts of nitrogen enrichment on soil carbon: plant, microbial, and geochemical controls
Open the record for dataset details and reuse information.
Data from: Top-down control of carbon sequestration: grazing affects microbial structure and function in salt marsh soils
Open the record for dataset details and reuse information.
Data from: The vertical distribution and control of microbial necromass carbon in forest soils
Open the record for dataset details and reuse information.
STAT3 regulates pathogen control and clearance in macrophages by reprogramming inflammation-induced microbial defense response
GEO Series GSE282695. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Metabolic interactions control the spread of plasmid-encoded functional novelty during microbial range expansion
<p>Data set for project "<em>Metabolic interactions control the spread of plasmid-encoded functional novelty during microbial range expansion</em>"</p>
Host-aware RNA-based control of microbial consortia
<p>Plasmid maps are provided as Genbank files.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.