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1,360 results for “Microglia”
Data from: Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10)
Microglia respond to CNS injuries and diseases with complex reactions, often called "activation." A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum. There were several motivations for this study. First, bacterial endotoxin (lipopolysaccharide, LPS) is the most commonly used pro-inflammatory stimulus for microglia, both in vitro and in vivo; however, pro-inflammatory cytokines (e.g., IFNγ, TNFα) rather than LPS will be encountered with sterile CNS damage and disease. We lack direct comparisons of responses between LPS and such cytokines. Second, while transcriptional profiling is providing substantial data on microglial responses to LPS, these studies mainly use mouse cells and models, and there is increasing evidence that responses of rat microglia can differ. Third, the cytokine milieu is dynamic after acute CNS damage, and an important question in microglial biology is: How malleable are their responses? There are very few studies of effects of resolving cytokines, particularly for rat microglia, and much of the work has focused on pro-inflammatory outcomes. Here, we first exposed primary rat microglia to LPS or to IFNγ+TNFα (I+T) and compared hallmark functional (nitric oxide production, migration) and molecular responses (almost 100 genes), including surface receptors that can be considered part of the sensome. Protein changes for exemplary molecules were also quantified: ARG1, CD206/MRC1, COX-2, iNOS, and PYK2. Despite some similarities, there were notable differences in responses to LPS and I+T. For instance, LPS often evoked higher pro-inflammatory gene expression and also increased several anti-inflammatory genes. Second, we compared the ability of two anti-inflammatory, resolving cytokines (IL-4, IL-10), to counteract responses to LPS and I+T. IL-4 was more effective after I+T than after LPS, and IL-10 was surprisingly ineffective after either stimulus. These results should prove useful in modeling microglial reactivity in vitro; and comparing transcriptional responses to sterile CNS inflammation in vivo.
Rapid phagosome isolation enables unbiased multiomic analysis of human microglia phagosomes 2
<p><span>Proteomic data of iPSC-derived microglia phagosomes and controls</span></p>
Alzheimer's disease-induced phagocytic microglia express specific profile of coding and non-coding RNAs
<p>This repository contains the data and the code used in Flavia's project.</p> <p>A folder can contain the starting raw data in "data", the R scripts in order of execution (op1, op2 ..) and the "output" folder that contains the final processed data of each operation.</p> <ul> <li>"BV2_analysis" contains the processing and analysis of the bulk RNA sequencing data with the different miRNAs in study</li> <li>"BV2_fastq_nfcore" contains the results of processing the fasta sequences with nfcore rnaseq workflow</li> <li>"Proinf_analysis" contains the analysis of the external bulk RNA sequencing data with the different studies of proinflammatory microglial cells</li> <li>"Spatial_data_analysis" contains the raw data of the spatial sequencing, the assempbly of the spatial expression profiles starting from the DAPI images and the transcripts coordinates, the analysis performed on the data</li> <li>"Spatial_U_scRNA_analysis" contains the code that integrates the spatial sequencing with the scRNA sequencing, plus the code of the analysis</li> </ul>
alternatively activated microglia
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9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis
ClinicalTrials.gov study NCT04510220. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation
ClinicalTrials.gov study NCT04230174. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Peripheral Benzodiazepine Receptors (PBR28) Brain PET Imaging With Lipopolysaccharide Challenge for the Study of Microglia Function in Alzheimer's Disease
ClinicalTrials.gov study NCT04057807. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess the Efficacy of Mayzent on Microglia in Secondary Progressive Multiple Sclerosis
ClinicalTrials.gov study NCT04925557. IPD Sharing: NO. Countries: 1. Publications: 0.
Study 3: Minocycline Decreases Microglia Activation
ClinicalTrials.gov study NCT02213575. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Data from: Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10)
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The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [RNA-seq]
GEO Series GSE271385. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Brain hypothyroidism leads to immune tolerance in microglia in Alzheimer's disease
GEO Series GSE219131. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Moderate intrinsic phenotypic alterations in C9orf72 ALS/FTD iPSC-microglia despite the presence of C9orf72 pathological features
GEO Series GSE233262. Homo sapiens. 68 samples. Type: Expression profiling by high throughput sequencing.
Fatostatin drug treatment of mouse primary microglia cultures
GEO Series GSE146864. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Fully defined human PSC-derived microglia and tri-culture system reveals cell type specific potentiation of complement C3 production in a model of Alzheimer’s disease [smarter-seq]
GEO Series GSE139549. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
single-cell RNA-seq profile of microglia under acute Csf1r inhibition and early repopulation in adult brain
GEO Series GSE150169. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq of isogenic NPC1 mutant iPSC-derived microglia like cells
GEO Series GSE184243. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq identifies a unique microglia type associated with Alzheimer’s disease
GEO Series GSE98971. Mus musculus. 104 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
scRNAseq from WT and PRMT1-KO microglia
GEO Series GSE199574. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
A microglia-containing cerebral organoid model to study early life immune challenges [scRNA-seq]
GEO Series GSE281452. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.