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302 results for “Middle Ages”
Low-frequency hearing thresholds improve as high-frequency hearing sensitivity deteriorates between young adulthood and middle age in normally hearing people
<p>Hearing sensitivity changes throughout a person's lifetime. This work aimed to describe changes in pure-tone audiometric (PTA) thresholds that occur in the transition from young adulthood to middle age in 121 adults with normal or nearly normal hearing. Results showed that older people had worse high-frequency (4000-8000 Hz) thresholds but unexpectedly better low-frequency (125-500 Hz) thresholds than younger individuals, suggesting that hearing sensitivity in the low-frequency range may improve with age. The improvement of low-frequency thresholds may be part of a central compensation for age-related deterioration of high-frequency hearing sensitivity. Further studies of age-related changes in low-frequency hearing sensitivity are needed to confirm our findings.</p>
Middle-Age House
Source: Objaverse 1.0 / Sketchfab
Middle Age Byzantine Amphora
Made with Blender Source: Objaverse 1.0 / Sketchfab
Data from: The genetic landscape of axonal neuropathies in the middle aged and elderly: focus on MME (supplementary information)
<p class="BarbaraStandard">OBJECTIVE: To test the hypothesis that monogenic neuropathies such as Charcot-Marie-Tooth disease (CMT) contribute to frequent but often unexplained neuropathies in the elderly, we performed genetic analysis of 230 patients with unexplained axonal neuropathies and disease onset <u>></u>35 years.</p> <p class="BarbaraStandard">METHODS: We recruited patients, collected clinical data and conducted whole-exome sequencing (WES, n=126) and <i>MME</i> single-gene sequencing (n=104). We further queried WES repositories for <i>MME</i> variants and measured blood levels of the <i>MME</i>-encoded protein neprilysin.</p> <p class="BarbaraStandard">RESULTS: In the WES cohort, the overall detection rate for assumed disease-causing variants in genes for CMT or other conditions associated with neuropathies was 18.3% (familial cases 26.4%, apparently sporadic cases 12.3%). <i>MME</i> was most frequently involved and accounted for 34.8% of genetically solved cases. The relevance of <i>MME</i> for late-onset neuropathies was further supported by detection of a comparable proportion of cases in an independent patient sample, preponderance of <i>MME</i> variants among patients compared to population frequencies, retrieval of additional late-onset neuropathy patients with <i>MME</i> variants from WES repositories, and low neprilysin levels in patients' blood samples. Transmission of <i>MME</i> variants was often consistent with an incompletely penetrant autosomal dominant trait and less frequently with autosomal recessive inheritance.</p> <p class="BarbaraStandard">CONCLUSIONS: A detectable fraction of unexplained late-onset axonal neuropathies is genetically determined, either by variants in CMT genes or genes involved in other conditions that affect the peripheral nerves and can mimic a CMT phenotype. <i>MME</i> variants can act as completely penetrant recessive alleles but also confer dominantly inherited susceptibility to axonal neuropathies in an aging population.</p> <p> </p>
The Effects of Pork vs. Chicken/Fish in a DASH Diet on Blood Pressure Regulation in Middle Aged and Older Adults
ClinicalTrials.gov study NCT01696097. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Korean Red Ginseng on Oxidation in Middle-aged and Elderly Sub-health Population
ClinicalTrials.gov study NCT05592093. IPD Sharing: NO. Countries: 1. Publications: 4.
Health Coaching Programme on Health Promoting Behaviours in Middle-Aged Adults With Cardiometabolic Risk
ClinicalTrials.gov study NCT05284162. IPD Sharing: NO. Countries: 1. Publications: 12.
The Benefit of Arthroscopic Partial Meniscectomy in Middle-Aged Patients
ClinicalTrials.gov study NCT01264991. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Comparison of the Effect of Exercises on Vasomotor Symptoms in Middle Aged Women
ClinicalTrials.gov study NCT05892094. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Telephone-delivered Behavioral Interventions to Reduce Risky Sexual Behavior in HIV-positive Late Middle-age and Older Adults
ClinicalTrials.gov study NCT01499706. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exergame-assisted Simultaneous Motor-cognitive Training for Middle-aged Old Adults in China
ClinicalTrials.gov study NCT07085663. IPD Sharing: NO. Countries: 1. Publications: 1.
The Efficacy of Oral Mitoquinone (MitoQ) Supplementation for Improving Physiological in Middle-aged and Older Adults
ClinicalTrials.gov study NCT02597023. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Changes in Microbiome and Metabolites Regarding Physical Activity in Middle-aged Korean Women
ClinicalTrials.gov study NCT05927675. IPD Sharing: NO. Countries: 1. Publications: 1.
Virtual Trainer System (3rd Version) for Physical Activity Promotion in Middle-aged Hong Kong Adults
ClinicalTrials.gov study NCT02553980. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Time-restricted Feeding on Physiological Function in Middle-aged and Older Adults
ClinicalTrials.gov study NCT02970188. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessing Lower Extremity Dynamic Stability in Middle-Aged and Elderly Patients With Patellofemoral Pain Using the Y-Balance Test
ClinicalTrials.gov study NCT07068984. IPD Sharing: YES. Countries: 1. Publications: 1.
Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain
ClinicalTrials.gov study NCT06978166. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of Intensive Lipid-Lowering Therapy on Coronary Atherosclerotic Plaque Progression in Young and Middle-Aged Patients With Chronic Coronary Syndrome
ClinicalTrials.gov study NCT06896708. IPD Sharing: NO. Countries: 1. Publications: 4.
Impact of Cocoa Flavanols on Pulmonary Oxygen Uptake Kinetics and Exercise Tolerance in Sedentary Middle-aged Adults
ClinicalTrials.gov study NCT04370353. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Community-based Depression Screening Intervention for Middle-aged Suicide
ClinicalTrials.gov study NCT02468466. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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OpenNeuro
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