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362 results for “Neuroinflammation”
Psychometric Evaluation in Patients With Brain Damage During Neuroinflammation
ClinicalTrials.gov study NCT05450237. IPD Sharing: UNDECIDED. Countries: 1. Publications: 9.
Neuroinflammation and Cognitive Decline in Alzheimer Disease
ClinicalTrials.gov study NCT02377206. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: Gut microbiota regulate motor deficits and neuroinflammation in a model of Parkinson’s disease
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Second wave, late-phase neuroinflammation in the brain of aged 5xFAD transgenic Alzheimer's disease model mice iden-tified using macrolaser light sheet microscopy imaging with tissue clearing
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Figure 4 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 4 Immunohistochemical staining of Caspase-3 400× microscope magnification. Picture of caspase 3 expression in the cerebral cortex area shows a picture of caspase 3 expression in the cytoplasm of neuron cells (yellow arrow). A. The normal control group showed a score of 0; B. The negative control group shows a score of 4; C. Group A shows a score of 3; D. Group B shows a score of 2; E. Group C shows a score of 1.
Figure 5 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 5 Histopathological picture of brain tissue damage with HE staining, 400× microscope magnification. Description: Histopathological picture of the cerebral cortex area shows degeneration of neuron cells (yellow arrows). A. The normal control group shows a score of 0; B. The negative control group shows a score of 2; C. Group A shows a score of 2; D. Group B shows a score of 1; E. Group C shows a score of 1.
Figure 2 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 2 TLR4 immunohistochemical staining with a microscope magnification of 400×. Description: TLR4 expression in the cerebral cortex area shows TLR4 expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 20%; C. Group A expressed 15%; D. Group B expressed 15%; E. Group C expressed 10%.
Figure 3 from: Nugroho A, Tamtomo DG, Indarto D, Cilmiaty R, Soetrisno (2024) The effect of L-Arginine from Giant Snake Head fish (Channa micropeltes) on neuroinflammation and neuron damage in traumatic brain injury in rats. Pharmacia 71: 1-9. https://doi.org/10.3897/pharmacia.71.e111239
Figure 3 TNF-α immunohistochemical staining with a microscope magnification of 400×. TNF-α expression in the cerebral cortex area shows TNF-α expression in astrocytes (yellow arrows). A. Control group normally expressed 5%; B. Negative control group expressed 15%; C. Group A was depressed 10%; D. Group B expressed 10%; E. Group C expressed 5%.
Association of aortic stiffness with biomarkers of neuroinflammation, synaptic dysfunction, and neurodegeneration
<p><b>Objectives:</b> To test the hypothesis that increased aortic stiffening is associated with greater cerebrospinal fluid (CSF) evidence of core Alzheimer's disease pathology (Ab, phosphorylated tau (p-tau)), neurodegeneration (total tau (t-tau)), synaptic dysfunction (neurogranin), neuroaxonal injury (neurofilament light (NFL)), and neuroinflammation (YKL-40, sTREM2), we analyzed pulse wave velocity (PWV) data and CSF data among older adults.</p> <p><b>Methods: </b>Participants free of stroke and dementia from the Vanderbilt Memory and Aging Project, an observational community-based study, underwent cardiac magnetic resonance to assess aortic pulse wave velocity (PWV, m/sec) and lumbar puncture to obtain CSF. Linear regressions related aortic PWV to CSF Ab, p-tau, t-tau, neurogranin, NFL, YKL-40, and sTREM2 concentrations adjusting for age, race/ethnicity, education, apolipoprotein (<i>APOE</i>) e4 status, Framingham Stroke Risk Profile, and cognitive diagnosis. Models were repeated testing PWV interactions with age, diagnosis, <i>APOE</i>-e4, and hypertension on each biomarker.</p> <p><strong>Results:</strong> 146 participants were examined (72±6 years). Aortic PWV interacted with age on p-tau (b=0.31, p=0.04), t-tau, (b=2.67, p=0.05), neurogranin (b=0.94, p=0.04), and sTREM2 (b=20.4, p=0.05). Among participants over age 73 years, higher aortic PWV related to higher p-tau (b=2.4, p=0.03), t-tau (b=19.3, p=0.05), neurogranin (b=8.4, p=0.01), and YKL-40 concentrations (b=7880, p=0.005). Aortic PWV had modest interactions with diagnosis on neurogranin (b=-10.76, p=0.03) and hypertension status on YKL-40 (b=-18020, p<0.001).</p> <p><b>Conclusions:</b> Among our oldest participants, age 74 years and older, greater aortic stiffening is associated with <i>in vivo</i> biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis. Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age.</p>
Data from: TSPO PET Using [18F]PBR111 reveals persistent neuroinflammation following acute diisopropylfluorophosphate intoxication in the rat
Acute intoxication with organophosphates (OPs) can trigger status epilepticus followed by persistent cognitive impairment and/or electroencephalographic abnormalities. Neuroinflammation is widely posited to influence these persistent neurological consequences. However, testing this hypothesis has been challenging, in part because traditional biometrics preclude longitudinal measures of neuroinflammation within the same animal. Therefore, we evaluated the performance of non-invasive positron emission tomography (PET), using the translocator protein (TSPO) radioligand [18F]PBR111 against classic histopathologic measures of neuroinflammation in a preclinical model of acute intoxication with the OP diisopropylfluorophosphate (DFP). Adult male Sprague Dawley rats administered pyridostigmine bromide (0.1 mg/kg, im) 30 min prior to administration of DFP (4 mg/kg, sc), atropine sulfate (2 mg/kg, im) and 2-pralidoxime (25 mg/kg, im) exhibited moderate-to-severe seizure behavior. TSPO PET performed prior to DFP exposure and at 3, 7, 14, 21 and 28 days post-exposure (DPE) revealed distinct lesions, as defined by increased standardized uptake values (SUV). Increased SUV showed high spatial correspondence to immunohistochemical evidence of neuroinflammation, which was corroborated by cytokine gene and protein expression. Regional SUV metrics varied spatiotemporally with DPE and correlated with the degree of neuroinflammation detected immunohistochemically. Furthermore, SUV metrics were highly correlated with seizure severity, suggesting that early termination of OP-induced seizures may be critical for attenuating subsequent neuroinflammatory responses. Normalization of SUV values to a cerebellar reference region improved correlations to all outcome measures and seizure severity. Collectively, these results establish TSPO PET using [18F]PBR111 as a robust, non-invasive tool for longitudinal monitoring of neuroinflammation following acute OP intoxication.
Examining Neuroinflammation in AlzHeimer's
ClinicalTrials.gov study NCT03548883. IPD Sharing: YES. Countries: 0. Publications: 4.
Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation
ClinicalTrials.gov study NCT04230174. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Impact of Post-ARDS Covid-19 Sedation on Persistent Neuroinflammation
ClinicalTrials.gov study NCT05233605. IPD Sharing: YES. Countries: 1. Publications: 0.
Neuroinflammation and Modulating Factors in Depression and HIV
ClinicalTrials.gov study NCT04286282. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Quantitative Assessment of Radiation-induced Neuroinflammation - A Proof of Principle Study
ClinicalTrials.gov study NCT05128903. IPD Sharing: YES. Countries: 1. Publications: 0.
PET Imaging of Neuroinflammation in Neurodegenerative Diseases Via a Novel Translocator Protein (TSPO) Radioligand
ClinicalTrials.gov study NCT03958630. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigation of Cannabidiol for Reduction of NeuroInflammation in Chronic Back Pain
ClinicalTrials.gov study NCT03891264. IPD Sharing: YES. Countries: 1. Publications: 0.
Evaluation of Neuroinflammation in Children With Infantile Spasms
ClinicalTrials.gov study NCT02092883. IPD Sharing: Not stated. Countries: 1. Publications: 0.
11C-Acetate PET/CT Imaging As a Biomarker of Amyloid-Induced Neuroinflammation
ClinicalTrials.gov study NCT02811744. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Data from: CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer's disease
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.