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1,012 results for “Neurology”
Smoking Cessation With Varenicline in Schizophrenia: Antipsychotic-Induced Neurological Symptoms as Correlates
ClinicalTrials.gov study NCT03495024. IPD Sharing: YES. Countries: 1. Publications: 7.
Neurologic Injuries in Adults With Urea Cycle Disorders
ClinicalTrials.gov study NCT00472732. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Modifying the Impact of ICU-Associated Neurological Dysfunction-USA (MIND-USA) Study
ClinicalTrials.gov study NCT01211522. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study Evaluating Oxybutynin in Patients With Neurogenic Overactive Bladder Associated With a Neurological Condition
ClinicalTrials.gov study NCT00224029. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Near-Infrared Laser Stimulation for Various Neurological Conditions
ClinicalTrials.gov study NCT04489082. IPD Sharing: NO. Countries: 1. Publications: 19.
Validation of a Brain-Computer Interface for Stroke Neurological Upper Limb Rehabilitation
ClinicalTrials.gov study NCT04724824. IPD Sharing: YES. Countries: 1. Publications: 2.
Neurological, Inflammatory and Metabolic Effects of Acute Mushroom Intervention in Older Adults
ClinicalTrials.gov study NCT05594329. IPD Sharing: NO. Countries: 1. Publications: 6.
Improving Neurological Health in Aging Via Neuroplasticity-based Computerized Exercise
ClinicalTrials.gov study NCT04149457. IPD Sharing: NO. Countries: 1. Publications: 2.
Clinical Study to Investigate the Efficacy and Safety of NT 201 Compared to Placebo in the Treatment of Chronic Troublesome Drooling Associated With Neurological Disorders and/or Intellectual Disabili
ClinicalTrials.gov study NCT02270736. IPD Sharing: NO. Countries: 6. Publications: 2.
Data from: TRANSCENDS: a career development program for underrepresented in medicine scholars in academic neurology
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Orthostatic hypotension, dizziness, neurology outcomes, and death in older adults, supplement methods & tables, STROND checklist
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Data from: Neurologic manifestations in an infant with COVID-19
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Data from: Headache study: The management of chronic headache with referral from primary care to direct access to Magnetic Resonance Imaging (MRI) compared to Neurology services: an observational prospective study in London
<p><b>Objectives</b>. To evaluate the cost, accessibility and patient satisfaction implications of two clinical pathways used in the management of chronic headache.</p> <p><b>Intervention</b>. Management of chronic headache following referral from Primary Care that differed in the first appointment, either a Neurology appointment or an MRI brain scan.</p> <p><b>Design and setting</b>. A pragmatic, non-randomised, prospective, single-center study at a Central Hospital in London.</p> <p><b>Participants. </b>Adult patients with chronic headache referred from Primary to Secondary Care.</p> <p><b>Primary and secondary outcome measures.</b> Participants' use of health care services and costs were estimated using primary and secondary care databases and questionnaires quarterly up to 12 months post-recruitment. Cost analyses were compared using generalised linear models (GLM). Secondary outcomes assessed: access to care, patient satisfaction, headache burden and self-perceived quality of life using headache-specific (MIDAS, HIT-6) and a generic questionnaire (EQ-5D-5L).</p> <p><b>Results. </b>Mean (SD) cost up to 6 months post-recruitment per participant was £578 (£420) for the Neurology group (n=128) and £245 (£172) for the MRI group (n=95), leading to an estimated mean cost difference of £333 (95% CI £253 to £413, p<0.001). The mean cost difference at 12 months increased to £518 (95% CI £401 to £637, p<0.001). When adjusted for baseline and follow-up imbalances between groups, this remained statistically significant. The utilisation of brain MRI improved access to care compared to the Neurology group (p<0.001). Participants in the Neurology group reported higher levels of satisfaction associated with the pathway and led to greater change in care management.</p> <p><b>Conclusion. </b>Direct referral to brain MRI from Primary Care led to cost-savings and quicker access to care but lower satisfaction levels when compared with referral to Neurology services. Further research into the use of brain MRI for a subset of patient population more likely to be reassured by a negative brain scan should be considered.</p>
Poisson models for publications, leadership and recognition awards in the American Academy of Neurology
<p>We sought to study sex with respect to publications, leadership and recognition awards in the American Academy of Neurology (AAN) in light of recent research highlighting inequities in these domains.</p> <p>Methods: We examined medical school graduation, neurology residency (using American Medical Association and the American Council for Graduate Medical Education), membership in the AAN, first and last authorship in <i>Neurology</i>, membership on AAN committees, and AAN recognition awards, by sex, in 1997, 2007, 2017. </p> <p>Results: Female medical students were less likely to enter neurology residency in 1997 only. In 2007 and 2017, there was no proportionate difference between men and women as last author, a surrogate for senior member of the author panel. In 2017, women were proportionately more likely to be first authors than men, a surrogate for principal investigator of the study. Committee membership was less for women in 1997 and 2007 (P <0.001) but was not proportionately different in 2017 (P=0.534). Women were proportionately more likely to receive recognition awards in all years studied (1997 p=0.008, 2007 p<0.001. 2017 p <0.001) although absolute numbers of women were less.</p> <p>Conclusions: Female membership, leadership (through committee membership), publications as last author were less in 1997 in the AAN. These same metrics demonstrated substantial proportionate changes, with no differences in last author in 2007 and 2017, greater likelihood for women to be first author in 2017, no differences in committee membership in 2017 and greater likelihood of receiving awards determined by merit in all three years. </p>
Data from: A novel longitudinal framework aimed at improving the teaching of the neurological examination
Objective: To develop an educational framework basis for improving the teaching of the neurological examination (NE) by asking German neurologists to (i) identify the basic elements of the screening NE, and (ii) nominate the steps they would deem mandatory for medical students to master. Methods: We conducted a questionnaire-based survey among neurologists working in a hospital or ambulatory setting in southwest Germany. To define the screening NE, neurologists were asked to list the NE components they normally use in clinical encounters with patients in whom neurological findings are unlikely. Furthermore, they were asked to identify additional elements of the NE which they would consider mandatory for students to master. Results: Our neurologists nominated a set of 23 elements as being essential for a screening NE. There was high consensus amongst the two groups and the results were concordant with international data. Furthermore, nearly 60 additional maneuvers of the NE were deemed obligatory for students to master. Conclusion: Our results reinforce the international consensus for screening NE components, and confirm a large set of additional examination steps that medical students should master, thereby indicating the need for an educational NE teaching concept. To solve this educational challenge, we propose a longitudinal curriculum that incorporates the "core + clusters" framework, thus combining the screening NE (core) with hypothesis-driven sets of maneuvers (clusters). Based on our data, we provide an initial proposal for the core and neurological diagnostic clusters which is applicable to both novice as well as advanced learners across the continuum of training.
Decreased content of ascorbic acid (vitamin C) in the brain of knockout mouse models of Na+, K+- ATPase-related neurologic disorders
<p><strong><span><span><span><span><span><span><span><span><span><span><span>Raw data, a2Ca3-dKO phenotype and dystonic spell of a3-HT</span></span></span></span></span></span></span></span></span></span></span></strong></p> <p><strong><span><span><span><span><span><span><span><span><span><span><span>We found brain haemorrhage phenotype of Atp1a2 and Atp1a3 doule knockout (α2α3-dKO) foetuses. Here we present two kinds of α2α3-dKO line, α2-Nα3-dKO andα2-Cα3-dKO, both show brain haemorrhage upon birth. They were similar to that of homozygous knockout of the gene encoding ascorbic acid (ASC orNvitamin C) transporter, SVCT2 (SVCT2-KO). We made SVCT2-knockout mouse line by CRIPR/CAS9 method. We present SVCT2-KO, showing brain hemorrage as α2α3-dKO. The α2α3-dKO and SVCT2-KO brain showed significantly decreased level of ASC compared with the wild-type (WT) and single knockout (here, raw data). We found that the ASC content in the basal ganglia and cerebellum was significantly lower in the adult <i>Atp1a3 </i>heterozygous knockout mouse (α3-HT) than in the WT (here, raw data). We did not observe increased oxidative stress in them (here raw data). Interestingly, we observed a significant decrease in the ASC level in the basal ganglia and cerebellum of α3-HTin the peripartum period, during which mice are under physiological stress(here, raw data). Here, we show dystonic spell of α3-HT in peripartum. These observations indicate that the α2 and α3 subunits independently contribute to the ASC level in the foetal brain and that the α3 subunit contributes to ASC transport in the adult basal ganglia and cerebellum. We propose that decreases in ASC levels may affect neural network development and are linked to the pathophysiology of <i>ATP1A2- </i>and <i>ATP1A3</i>-related neurologic disorders.</span></span></span></span></span></span></span></span></span></span></span></strong></p>
Data from: Telemedicine in neurology: telemedicine work group of the American Academy of Neurology update
ABSTRACT Purpose: While there is strong evidence supporting the importance of telemedicine in stroke, its role in other areas of neurology is not as clear. The goal of this review is to provide an overview of evidence-based data regarding the role of teleneurology in the care of patients with neurologic disorders other than stroke. Recent findings: Studies across multiple specialties report noninferiority of evaluations by telemedicine compared with traditional, in-person evaluations in terms of patient and caregiver satisfaction. Evidence reports benefits in expediting care, increasing access, reducing cost, and improving diagnostic accuracy and health outcomes. However, many studies are limited and gaps in knowledge remain. Summary: Telemedicine use is expanding across the vast array of neurologic disorders. More studies are needed to validate and support its use.
Neurology paper "Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study" Table e-1
<p>Our Neurology 2020 paper titled "<span><a><b>Sequence of Alzheimer disease biomarker changes </b></a><b>in cognitively normal </b></span><b>adults: A cross-sectional study" explores the cascades of </b>changes of several well-known Alzheimer disease (AD) markers including cerebrow spinal fluid (CSF), imaging (PET-PIB and MRI) and cognitive markers in cognitively normal participants. The baseline marker data of participants is modeled as a piecewise linear function of baseline age allowing one change point, without and with adjustment for covariates. The change point of a marker incicates the acceleration time of point after which a greater percentage of the participants present preclinical AD compared to before the change point. Cosnistent with previous research, the study confirmed that Abeta42 showed the earliest change-point around 50 years old and cognition had a late change point around 62. The study further found Tau, pTau and MRI hippalcampal volume had their change point closer to cognition. We identified change points in all participants, as well as by stratification of APOE4 status. The data here displays the Supplemental table Table e-1 accompanying the paper where the change point results by stratification of APOE4 status are presented.</p> <div> <div> <div class="msocomtxt"> </div> </div> </div> <p> </p>
Global & Community Health: Implementation of and patient satisfaction with the first neurologic telemedicine program in Mexico during COVID-19
<p>Since the coronavirus disease 2019 (COVID-19) pandemic outbreak, due to the large number of patients requiring in-hospital care, hospitals worldwide were converted into COVID-19 referral centers. In addition, as part of the mitigation strategies besides social distancing and mandatory use of facemasks, other measures to reduce the risk of infection among healthcare workers such as increasing the time between work shifts and sending high-risk personnel to in-home isolation were taken, leading to a significantly reduced workforce, requiring relocation of medical personnel from multiple specialties to the frontline. </p> <p>By April 2020, due to the reduction of medical and administrative staff in addition to the steadily increasing number of patients, our center decided to stop all face-to-face non-COVID-19 consultations. Therefore, we decided to adapt to the challenges and started researching how to implement a teleneurology program to re-open our neurology continuity clinic. Here, we describe our experience developing and implementing a teleneurology program in Mexico and patient satisfaction with our program.</p> <p>To assess patient satisfaction and quality of the healthcare received, at the end of the consultations, to those who had internet access, we sent via e-mail or text message an anonymous 24-question online-based questionnaire (modified for the COVID-19 pandemic) developed and validated for the Spanish-speaking population.</p> <p>We included 304 patients. The most common neurologic disorders we attended were neuromuscular disorders in 33.6% of patients, headache disorders in 32.9%, epilepsy in 11.5%, cerebrovascular diseases in 5.9%, and movement disorders in 5.6%. None of the patients required an in-person visit. Of the 304 patients, only 125 (41%) answered the survey, 86.4% preferred teleneurology instead of an in-person consultation, 83.3% (90/108) of them because of concerns about getting COVID-19; 92% completely agree that they felt comfortable when talking to the neurologist through a camera and a microphone; 96% reported being satisfied with their consultation; 87.2% completely agree in trusting that their privacy would be protected. However, 4% were not satisfied, but their reasons were not specified. Our findings suggest that telemedicine is a feasible and acceptable option to continue with neurological patient care during the COVID-19 pandemic.</p>
Assessment of insight in hospitalized neurological patient: Cognitive profile and mood disorder
<p>Purpose:Many studies have evaluated the characteristics of insight, especially in psychiatric patient pop-ulations. However, this construct has been poorly examined within neurological disorders. We exploredthe relationship between altered insight, mood disorders and neurocognitive functioning in a sample ofpatients admitted to a neurological rehabilitation unit.Method:Each patient, at the time of hospitalization (T0), underwent an evaluation of the overall cogni-tive profile, of the frontal functions, and the compilation of scales aimed at investigating the 4 domainsunder examination of insight and anxiety-depressive symptomatology. After 3 months (T1), at the end ofthe rehabilitative and supportive treatment, the patients underwent the same evaluation performed atT0.Results:Our results showed significant differences between T0 and T1 in the variables examined relatedto insight. In particular, there was a correlation between the global cognitive profile, including executivefunctions, and all insight domains. This confirms how the degree of cognitive deficit, especially of exec-utive type, affects all levels of awareness of the individual.We have also found correlations between mood disorders and insight. In particular, our results showthat depression versus anxiety plays a fundamental role in a person’s awareness.Conclusions:The study of insight is fundamental not only for the relapses it could have on the patient, butalso on those to health care professionals. In fact, having an adequate insight could lead to a greater moti-vation of the patient to be more complimentary to pharmacological and rehabilitative therapies, alsofavoring social reintegration.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.