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172 results for “P450”
Fig. 2. CYP72A in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 2. CYP72A multiple sequence alignment. Signal anchor domain fusion of CYP72A565 into CYP72A564 is underlined; SRS regions are underlined in bold; predicted substrate contacts within 4.5 Å of loganic acid/loganin are gray-filled.
Fig. 1 in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 1. Proposed divergence of the TIA pathway between Camptotheca and Catharanthus. After 7-deoxyloganic acid hydroxylase (7DLH) converts 7-deoxyloganic acid to loganic acid, the pathways in these two species diverge. The Catharanthus pathway uses loganic acid methyltransferase (LAMT) to convert loganic acid into loganin and secologanin synthase (SLS) to convert loganin into secologanin. The Camptotheca pathway bypasses LAMT and uses secologanic acid synthase (SLAS) to metabolize loganic acid directly to secologanic acid.
Fig. 8 in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 8. Molecular models of Camptotheca CYP72A564, CYP72A565 and CYP72A730. (A) Backbone overlays of Camptotheca CYP72A730, CYP72A564 and CYP72A565 models are shown with the RMSD variance of CYP72A564 and CYP72A565 from the CYP72A730 backbone depicted in green (0.0 Å), yellow (3.0 Å) and red (4.5 Å). (B) SRS regions in CYP72A proteins shown with predicted substrate contact residues (gray fill). (C) Identical versus (D) different side chain residues predicted within 4.5 Å of loganic acid (gray) docked in Camptotheca CYP72A564 (orange) versus loganic acid (aqua) docked in CYP72A730 (magenta). (E) Identical versus (F) different side chain residues predicted within 4.5 Å of loganic acid (gray) docked in Camptotheca CYP72A565 (rose) versus loganic acid (aqua) docked in CYP72A730 (magenta).
Fig. 4 in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 4. LC-MS analyses of in vitro assays with purified His6-tagged CYP72A proteins reconstituted with His6-tagged CPR proteins. Reactions containing purified His6- tagged CYP72A protein, full-length His6-tagged Caa CPR1 protein (A, B) or full-length His6-tagged Caa CPR2 protein (C, D), and 250 μM loganic acid (A,C) or loganin (B,D), were incubated at 30◦ C and analyzed by LC-MS as described in experimental procedures. Extracted ion chromatograms for loganic acid (m/z 375.1297), secologanic acid (m/z 373.1140), secoxyloganic acid (m/z 389.1089); loganin sodium salt (m/z +413.1418), secologanin sodium salt (m/z +411.1262), secoxyloganin (m/z 403.1246) are given with stacked chromatograms as marked.
Fig. 3 in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 3. LC-MS analyses of in vitro assays with CYP72A proteins expressed in yeast microsomes. 100 μl reactions containing 10 μl CYP72A microsomes isolated from WAT11 with 250 μM loganic acid or loganin and 500 μM NADPH in 100 mM NaPO (pH 7.4) were incubated at 30◦ C and analyzed by LC-MS as 4 described in the experimental procedures. (A) Extracted ion chromatograms for loganic acid (m/z 375.1297), secologanic acid (m/z 373.1140), secoxyloganic acid (m/z 389.1089). (B) Extracted ion chromatograms for loganin sodium salt (m/z +413.1418), secologanin sodium salt (m/z +411.1262), secoxyloganin (m/z 403.1246).
Fig. 6. Type I in P450 variations bifurcate the early terpene indole alkaloid pathway in Catharanthus roseus and Camptotheca acuminata
Fig. 6. Type I binding spectra of SLAS candidates. Substrate-induced Type I binding spectra for (A) CYP72A564, (B) CYP72A565 and from 998 nM (violet) to 1.90 mM (crimson) using loganic acid (top inset) or loganin (bottom inset). (C) Binding isotherms calculated as the difference of the valley (~419 nm) from the peak (~388 nm) are shown for loganic acid () and loganin (). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Cytochrome P450 Inhibition to Decrease Dosage of Dasatinib for Chronic Myelogenous Leukemia
ClinicalTrials.gov study NCT05638763. IPD Sharing: NO. Countries: 1. Publications: 3.
Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe
ClinicalTrials.gov study NCT02680808. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Investigate Safety, Tolerability, and Pharmacokinetics (PK) of VH4524184 and the Potential for Changes in Cytochrome P450 3A (CYP3A) Activity
ClinicalTrials.gov study NCT05631704. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study To Test The Effect Of GW786034 (Pazopanib) On P450 Enzymes
ClinicalTrials.gov study NCT00401583. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects
ClinicalTrials.gov study NCT02820935. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cocktail Approach for Cytochrome P450 and P-glycoprotein Activity Assessment Using Dried Blood Spot
ClinicalTrials.gov study NCT01731067. IPD Sharing: Not stated. Countries: 1. Publications: 1.
In Vivo Determination of Cytochrome P450 Activities in Patients With Liver Cirrhosis
ClinicalTrials.gov study NCT03337945. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Coliti
ClinicalTrials.gov study NCT04254783. IPD Sharing: NO. Countries: 3. Publications: 1.
Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein
ClinicalTrials.gov study NCT02515526. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cytochrome P450-2D6 Screening Among Elderly Using Antidepressants (CYSCE)
ClinicalTrials.gov study NCT01778907. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cytochrome P450 2D6 Genotype on the Clinical Effect of Carvedilol
ClinicalTrials.gov study NCT02286934. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Development of Cocktail for Measuring the Activity of Important Cytochrome P450 Enzymes
ClinicalTrials.gov study NCT00981929. IPD Sharing: Not stated. Countries: 1. Publications: 1.
CYTRAM (Cytochrome P450, Tramadol)
ClinicalTrials.gov study NCT00952159. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Polymorphism of the Cytochrome P450-system in Renal Transplants
ClinicalTrials.gov study NCT00223054. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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