Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
471
datasets available to search
ShareScore release 0.9.0
Dataset results
471 results for “Protein targets”
Dataset for article: "Massively parallel de novo protein design for targeted therapeutics", DOI: 10.1038/nature23912
<p><strong>"Massively parallel de novo protein design for targeted therapeutics" </strong></p> <p>DOI: 10.1038/nature23912 </p> <p><strong>Supplementary Information</strong>. Archive of designs, Rosetta metrics and experimental results.</p> <p>Authors: <strong>Aaron Chevalier*</strong>, <strong>Daniel-Adriano Silva*</strong>, <strong>Gabriel J. Rocklin*</strong>, Derrick R. Hicks, Renan Vergara, Patience Murapa, Steffen M. Bernard, Lu Zhang, Kwok-ho Lam, Guorui Yao, Christopher D. Bahl, Shin-ichiro Miyashita, Inna Goreshnik, James T. Fuller, Merika T. Koday, Cody Jenkins, Tom Colvin, Lauren Carter, Alan Bohn, Cassie M. Bryan, D. Alejandro Fernández-Velasco, Lance Stewart, Min Dong, Xuhui huang, Rongsheng Jin, Ian A. Wilson, Deborah H. Fuller & <strong>David Baker</strong></p> <p><strong>*These authors contributed equally to this work</strong>.</p> <p>Correspondence to: dabaker@uw.edu</p> <p>Dataset Compiled by D-A.S.</p> <p>Date: 13/Sep/2017</p>
In-house sequence database of S.pn recombinant protein vaccine target-related genes
<p>In-house sequence database of S.pn recombinant protein vaccine target-related genes.</p>
Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein
<p>Dataset pertaining to Strategy of selection and optimization of single domain antibodies targeting the PHF6 linear peptide within the Tau intrinsically disordered protein</p>
Supplementary data for "Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging"
<p>Supplementary data for "Engineering PD-1-targeted small protein variants for in vitro diagnostics and in vivo PET imaging". The docking.zip file contains ClusPro protein/protein docking results for all binding protein variants using either murine PD-1 structure (3bikB) or human PD-1 AF2 model as receptors. The pymol session contains data and scenes used to generate the Figures in the paper.</p>
Time to Protein Target Using a High Whey Protein Enteral Nutrition in Critically Ill Patients
ClinicalTrials.gov study NCT02815527. IPD Sharing: NO. Countries: 1. Publications: 4.
Pooled Mutant KRAS-Targeted Long Peptide Vaccine Combined With Nivolumab and Ipilimumab for Patients With Resected Mismatch Repair Protein (MMR-p) Colorectal and Pancreatic Cancer
ClinicalTrials.gov study NCT04117087. IPD Sharing: NO. Countries: 1. Publications: 0.
Modified White Blood Cells That Secrete IL-2 and Express a Protein That Targets the ESO-1tumor Protein for Metastatic Cancer
ClinicalTrials.gov study NCT01457131. IPD Sharing: Not stated. Countries: 1. Publications: 3.
First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients
ClinicalTrials.gov study NCT05964361. IPD Sharing: NO. Countries: 1. Publications: 2.
Targeted Protein Fortification in Extremely Low Birth Weight Preterm Infants
ClinicalTrials.gov study NCT02943746. IPD Sharing: NO. Countries: 1. Publications: 3.
A Dose Finding Pharmacokinetic Study of the Tumour-targeting Human L19IL2 Monoclonal Antibody-Cytokine Fusion Protein in Patients With Advanced Solid Tumours
ClinicalTrials.gov study NCT01058538. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Evaluation on Seropositive Patients of a Synthetic Vaccine Targeting the HIV Tat Protein
ClinicalTrials.gov study NCT01793818. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Molecular docking and dynamics studies to identify novel active compounds targeting potential breast cancer receptor proteins from an indigenous herb Euphorbia thymifolia Linn
Open the record for dataset details and reuse information.
Data and scripts involved in protein target screening by UNSW iGEM 2022
<p>Data and scripts involved in protein target screening by UNSW iGEM 2022.</p>
Activity-based protein profiling for target identification of JCP276 in Mycobacterium tuberculosis
<p><span><span><span><span><span><span><span><span><span><span><span>The increasing incidence of antibiotic-resistant <i>Mycobacterium tuberculosis </i>infections is a growing global health threat necessitating the development of new antibiotics. Serine hydrolases (SHs) are a promising class of targets because of their importance for the synthesis of the mycobacterial cell envelope. We screened a library of small molecules containing serine-reactive electrophiles and identified a series of narrow spectrum inhibitors of <i>M. tuberculous </i>growth. Using these lead molecules we performed competitive activity-based protein profiling and identified SH targets, including enzymes with uncharacterized functions. Lipidomic analyses of compound-treated cultures revealed an accumulation of free lipids and a substantial decrease in lipooligosaccharides, linking SH inhibition to defects in cell envelope biogenesis. Mutant analysis revealed a path to resistance via the synthesis of mycocerates, but not through mutations to target enzymes. We conclude that simultaneous inhibition of multiple SH enzymes is likely to be an effective therapeutic strategy.</span></span></span></span></span></span></span></span></span></span></span></p>
Mapping Synthetic Binding Proteins Epitopes on Diverse Protein Targets by Protein Structure Prediction and Protein-Protein Docking
<p>The predicted 3D structures of 145 SBPs and the 96 models of SBPs in complex with protein targets.</p>
GcForest-based Compound-Protein Interaction Prediction Model and Its Application in Discovering Small-Molecule Drugs Targeting CD47
<p><strong>This is a file of all raw data and processed data concerned in the article "GcForest-based Compound-Protein Interaction Prediction Model and Its Application in Discovering Small-Molecule Drugs Targeting CD47", this file contain 6 sub-files, namely GCVec——humans, GCVec——celegans, GCVec——challenging dataset, GCVec——latest BindingDB, GCVec——known CD47 inhibitors, GCVec——specs, respectively, fully cover all parts of the article.</strong></p>
Treatment of Chinese Participants With B-Cell Malignancies With BGB-16673, a Bruton Tyrosine Kinase-Targeted Protein-Degrader
ClinicalTrials.gov study NCT05294731. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study to Learn if 27T51, a Mucin-16 (MUC16) Protein Targeting Immune Cell Therapy, Administered Alone or in Combination is Safe and How Well it Works for Adult Participants With Recurrent or Treatme
ClinicalTrials.gov study NCT06469281. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: A targeted in situ hybridization screen identifies putative seminal fluid proteins in a simultaneously hermaphroditic flatworm
Open the record for dataset details and reuse information.
Activity-based protein profiling for target identification of JCP276 in Mycobacterium tuberculosis
Open the record for dataset details and reuse information.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.