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565
datasets available to search
ShareScore release 0.9.0
Dataset results
565 results for “RAS”
A Study of Avelumab, Binimetinib and Talazoparib in Patients With Locally Advanced or Metastatic RAS-mutant Solid Tumors
ClinicalTrials.gov study NCT03637491. IPD Sharing: NO. Countries: 3. Publications: 2.
A Study of Nimotuzumab Combinated With Gemcitabine in K-RAS Wild-type Locally Advanced and Metastatic Pancreatic Cancer
ClinicalTrials.gov study NCT02395016. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The RAS, Fibrinolysis and Cardiopulmonary Bypass
ClinicalTrials.gov study NCT00607672. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Phase II Trial of Pimasertib Versus Dacarbazine in N-Ras Mutated Cutaneous Melanoma
ClinicalTrials.gov study NCT01693068. IPD Sharing: Not stated. Countries: 14. Publications: 1.
Health Evaluation in African Americans Using RAS Therapy
ClinicalTrials.gov study NCT02471833. IPD Sharing: NO. Countries: 1. Publications: 1.
Cetuximab in Refractory Colorectal Cancer With K-RAS Mutated and Favorable FcγRIIa (CD32) Genotype
ClinicalTrials.gov study NCT01450319. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Hepatic Arterial Infusion With Intravenous Irinotecan, 5FU and Leucovorin With or Without Panitumumab, in Patients With Wild Type RAS Who Have Resected Hepatic Metastases From Colorectal Canc
ClinicalTrials.gov study NCT01312857. IPD Sharing: Not stated. Countries: 1. Publications: 1.
RAS and Coagulopathy in COVID19
ClinicalTrials.gov study NCT04419610. IPD Sharing: NO. Countries: 1. Publications: 1.
Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With RAS Wild-Type Locally Advanced or Metastatic Colorectal Cancer That Cannot Be Removed by Surgery
ClinicalTrials.gov study NCT02292758. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Prospective, Single-center, Single-arm, Pivotal Trial of the Medtronic Hugo™ Robotic Assisted Surgery (RAS) System
ClinicalTrials.gov study NCT05715827. IPD Sharing: NO. Countries: 1. Publications: 1.
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12D Variant of Mutated RAS in HLA-A*11:01 Patients
ClinicalTrials.gov study NCT03745326. IPD Sharing: YES. Countries: 1. Publications: 3.
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
ClinicalTrials.gov study NCT05696444. IPD Sharing: NO. Countries: 1. Publications: 0.
EMD 525797 in Combination With Cetuximab and Irinotecan in K-ras Wild Type Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT01008475. IPD Sharing: Not stated. Countries: 12. Publications: 1.
Excited state observation of active K-Ras reveals differential structural dynamics of wild-type versus oncogenic G12D and G12C mutants
Open the record for dataset details and reuse information.
Hydraulic model (HEC-RAS) of downstream of Tuttle Creek Reservoir at the confluence of the Big Blue River and the Kansas River near Manhattan, KS
Open the record for dataset details and reuse information.
Cost-effectiveness analysis of cetuximab combined with chemotherapy as a first-line treatment for RAS wild-type metastatic colorectal cancer patients based on the TAILOR trial
<p><b>Objectives</b> Cetuximab plus leucovorin, fluorouracil, and oxaliplatin (FOLFOX-4) is superior to FOLFOX-4 alone as a first-line treatment for patients with RAS wild-type metastatic colorectal cancer (wt mCRC), with significantly improved survival benefit by TAILOR, an open-label, randomized, multicentre, phase III trial. Nevertheless, the cost-effectiveness of these two regimens remains uncertain. The following study aims to determine whether cetuximab combined with FOLFOX-4 is a cost-effective strategy for specific RAS wt mCRC patients in China.</p> <p><b>Design</b> A combined decision tree and Markov model with three health states (stable, progressive and dead) was constructed to simulate a hypothetical cohort of patients with RAS wt mCRC. The health outcomes and utility scores were derived from the TAILOR trial and previously published sources, respectively. Costs were calculated with reference to the Chinese societal perspective. A lifetime horizon was used. Univariate and probabilistic sensitivity analyses were carried out to test the robustness of the model results.</p> <p><b>Participants</b> The included patients were newly diagnosed Chinese patients with fully RAS wt mCRC. <b>Interventions</b> Either cetuximab plus FOLFOX-4 or FOLFOX-4 alone as a first-line treatment.</p> <p><b>Main outcome measures</b> The primary outcomes are costs, quality-adjusted life-years (QALYs) and incremental cost-effectiveness ratios (ICERs).</p> <p><b>Results</b> Baseline analysis showed that the addition of cetuximab increased the QALYs by 0.383, while an increase of $62,947 was observed in relation to FOLFOX-4 chemotherapy. This led to an incremental cost-effectiveness ratio (ICER) of $164,044/QALY. Sensitivity analysis showed that across the wide variation in parameters, the ICER exceeded the willingness-to-pay threshold of $28,106/QALY, which was three times the per capita GDP in China.</p> <p><b>Conclusions</b> Despite the survival benefit, cetuximab combined with FOLFOX-4 is not a cost-effective treatment for the first line treatment of patients with RAS wt mCRC in China.</p>
Ras Baalbek
Ras Baalbek village in the northern Beqaa Valley in Lebanon Source: Objaverse 1.0 / Sketchfab
FIGURE 5 in Notes on holotypes of hermit crabs (Decapoda: Anomura: Paguroidea) deposited in the collection of Zoological Museum of RAS (Saint-Petersburg, Russia) with remarks on hermit crab diversity along the Russian coast of the Sea of Japan
FIGURE 5. Specimens of Elassochirus cavimanus (Miers, 1879) labelled in 1852 by F.F. Brandt as "Pagurus kadjakensis sp. nov." from collections of the Zoological Institute of RAS (St. Petersburg, Russia).
FIGURE 4 in Notes on holotypes of hermit crabs (Decapoda: Anomura: Paguroidea) deposited in the collection of Zoological Museum of RAS (Saint-Petersburg, Russia) with remarks on hermit crab diversity along the Russian coast of the Sea of Japan
FIGURE 4. Photo of alive Clibanarius virescens (Krauss, 1843) from Japan taken from WWW (http://web.nchu.edu.tw/ ~htshih/hermit/list_hc/Cl_vires.htm) and the original drawing of the holotype of Clibanarius sachalinicus Kobjakova, 1955 (from Kobjakova, 1955).
FIGURE 3 in Notes on holotypes of hermit crabs (Decapoda: Anomura: Paguroidea) deposited in the collection of Zoological Museum of RAS (Saint-Petersburg, Russia) with remarks on hermit crab diversity along the Russian coast of the Sea of Japan
FIGURE 3. Holotype (female) of Clibanarius sachalinicus Kobjakova, 1955 (=Clibanarius virescens (Krauss, 1843)): a—general view of the holotype; b—carapace; c—right cheliped; d—left cheliped; e—left side appendages; f—telson; g—original label.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
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