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Dataset results
494 results for “VEGF”
Study of AVE0005 (VEGF Trap) in Locally Advanced or Metastatic Platinum- and Erlotinib- Resistant Non-small-cell-lung Adenocarcinoma
ClinicalTrials.gov study NCT00284141. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Study of Tivozanib (AV-951), an Oral VEGF Receptor Tyrosine Kinase Inhibitor, in the Treatment of Renal Cell Carcinoma
ClinicalTrials.gov study NCT00502307. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Anti-VEGF vs. Prompt Vitrectomy for VH From PDR
ClinicalTrials.gov study NCT02858076. IPD Sharing: Not stated. Countries: 2. Publications: 3.
YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling
<p>Lymphatic vasculature is an integral part of digestive, immune and circulatory systems. The homeobox transcription factor PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs). We and others previously reported a feedback loop between PROX1 and Vascular Endothelial Growth Factor-C (VEGF-C) signaling. PROX1 promotes the expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs). In turn, VEGF-C signaling maintains PROX1 expression in LECs. However, the mechanisms of PROX1/VEGF-C feedback loop remain poorly understood. Whether VEGF-C signaling is necessary for LV and LVV development is also unknown. Here, we report for the first time that VEGF-C signaling is necessary for valve morphogenesis. We have also discovered that the transcriptional co-activators YAP and TAZ are required to maintain PROX1 expression in LVs and LVVs in response to VEGF-C signaling. Deletion of <i>Yap</i> and <i>Taz</i> in the lymphatic vasculature of mouse embryos did not affect the formation of LVs or LVVs, but resulted in the degeneration of these structures. Our results have identified VEGF-C/YAP/TAZ as a critical molecular pathway in valve development.</p>
( R, S)-Equol 7-β-D-glucuronide, but not other circulating isoflavone metabolites, modulates migration and tubulogenesis in human aortic endothelial cells targeting the VEGF pathway
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The Effect of Monoclonal Vascular Endothelial Growth Factor (VEGF) Antibody (Bevacizumab) on Pituitary Function
ClinicalTrials.gov study NCT00973557. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Validation of Tie2 as the First Tumour Vascular Response Biomarker for VEGF Inhibitors: VALTIVE1
ClinicalTrials.gov study NCT04523116. IPD Sharing: Not stated. Countries: 1. Publications: 2.
FLuoresence Image Guided Surgery With A VEGF-targeted Tracer in Soft-tissue Sarcomas in Humans Approach With Bevacizumab-IRDye 800CW
ClinicalTrials.gov study NCT03913806. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Protective VEGF Inhibition for Isotoxic Dose Escalation in Glioblastoma
ClinicalTrials.gov study NCT05871021. IPD Sharing: NO. Countries: 1. Publications: 1.
VEGF Trap in Treating Patients With Solid Tumors or Non-Hodgkin's Lymphoma
ClinicalTrials.gov study NCT00045266. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers
ClinicalTrials.gov study NCT02325271. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Systemic Pharmacokinetics Following Intravitreal Injections of Anti-VEGF
ClinicalTrials.gov study NCT02118831. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study to Assess the Effectiveness of Existing Anti vascUlar Endothelial Growth Factor (Anti VEGF) in Patients With Wet Age-related Macular Degeneration (wAMD) (AURA)
ClinicalTrials.gov study NCT01447043. IPD Sharing: Not stated. Countries: 10. Publications: 2.
Prospective Study of Adjunctive Carotenoids Plus Anti-oxidants in Anti-VEGF Treated Diabetic Macular Edema
ClinicalTrials.gov study NCT03866005. IPD Sharing: NO. Countries: 1. Publications: 1.
VEGF Trap in Treating Patients With Relapsed or Refractory Solid Tumors or Non-Hodgkin's Lymphoma
ClinicalTrials.gov study NCT00036946. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of Safety and Efficacy of Brolucizumab 6 mg Dosed Every 4 Weeks Compared to Aflibercept 2 mg Dosed Every 4 Weeks in Patients With Retinal Fluid Despite Frequent Anti-VEGF Injections
ClinicalTrials.gov study NCT03710564. IPD Sharing: YES. Countries: 2. Publications: 0.
Seven-year Outcomes Following Intensive Anti-VEGF Therapy in Wet AMD
ClinicalTrials.gov study NCT05678517. IPD Sharing: NO. Countries: 1. Publications: 1.
Anti-VEGF Therapy for Acute Thyroid Eye Disease
ClinicalTrials.gov study NCT04311606. IPD Sharing: YES. Countries: 1. Publications: 8.
Vascular Endothelial Growth Factor (VEGF) & LOC387715/HTRA1 Polymorphism in Polypoidal Choroidal Vasculopathy
ClinicalTrials.gov study NCT01233128. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Head to Head Study of Anti-VEGF Treatment.
ClinicalTrials.gov study NCT02577107. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.