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Dataset results
71 results for “adult congenital heart disease”
Bosentan Improves Clinical Outcome of Adults With Congenital Heart Disease or Mitral Valve Lesions Who Undergo CArdiac Surgery
ClinicalTrials.gov study NCT01184404. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Feasibility Study of the Adult Congenital Heart Disease-Coping and Resilience (ACHD-CARE) Trial
ClinicalTrials.gov study NCT01881893. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Development of a Quality of Life Assessment Tool for Adult Patients With a Congenital Heart Disease, Having Had Surgery During Childhood
ClinicalTrials.gov study NCT03917706. IPD Sharing: NO. Countries: 1. Publications: 0.
Supported Exercise Programme for Adults With Congenital Heart Disease
ClinicalTrials.gov study NCT03262168. IPD Sharing: NO. Countries: 1. Publications: 0.
Interval Training in Adults With Congenital Heart Disease a Randomized Trial
ClinicalTrials.gov study NCT01671566. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prevalence of Obesity Among Adult Patients With Congenital Heart Disease: a Population-based Study
ClinicalTrials.gov study NCT06661434. IPD Sharing: NO. Countries: 1. Publications: 0.
Search for Noninvasive Markers of "Graft Injury" in Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Transplantation
ClinicalTrials.gov study NCT06784440. IPD Sharing: NO. Countries: 1. Publications: 0.
Adult Congenital Heart Disease Surgery
ClinicalTrials.gov study NCT00446160. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Real-World Data on the Effects of Cardiac Resynchronization Therapy in Adult Patients With Congenital Heart Disease
ClinicalTrials.gov study NCT06969924. IPD Sharing: Not stated. Countries: 1. Publications: 0.
NT-proBNP Levels in the Prediction of Intrapartum and Postpartum Events in Adult Congenital Heart Disease Patients
ClinicalTrials.gov study NCT04231591. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ST2, a Novel Biomarker for Cardiac Remodeling in Adults With Congenital Heart Disease
ClinicalTrials.gov study NCT01774890. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy Of Sodium Glucose Transporter Inhibitor (SGLT2I) In Adult Patients With Congenital Heart Disease
ClinicalTrials.gov study NCT06260059. IPD Sharing: NO. Countries: 1. Publications: 0.
Expression of candidate genes associated with congenital heart disease in adult human atrial and ventricular tissue
GEO Series GSE161016. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Empiric Pulsed Field Pulmonary Vein Isolation During Atrial Tachycardia Ablation in Adults With Congenital Heart Disease
ClinicalTrials.gov study NCT06969378. IPD Sharing: NO. Countries: 0. Publications: 0.
Effect of Tirzepatide on Cardiovascular and Metabolic Parameters in Obese Adult Patients With Congenital Heart Disease
ClinicalTrials.gov study NCT07354880. IPD Sharing: YES. Countries: 0. Publications: 0.
Effects of Iloprost Treatment in Adult Patients With Pulmonary Arterial Hypertension Related to Congenital Heart Disease
ClinicalTrials.gov study NCT01383083. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Data set from the article Malavazos AE, Capitanio G, Chessa M, Matelloni IA, Milani V, Stella E, Al Kassem LF, Sironi F, Boveri S, Giamberti A, Masocco M, Ranucci M, Menicanti L, Morricone L. Body mass index stratification in hospitalized Italian adults with congenital heart disease in relation to complexity, diagnosis, sex and age. Nutr Metab Cardiovasc Dis. 2019 Apr;29(4):367-377. doi: 10.1016/j.numecd.2019.01.009. Epub 2019 Jan 29. PMID: 30795994.
<p>The data set refers on the article Malavazos AE, Capitanio G, Chessa M, Matelloni IA, Milani V, Stella E, Al Kassem LF, Sironi F, Boveri S, Giamberti A, Masocco M, Ranucci M, Menicanti L, Morricone L. Body mass index stratification in hospitalized Italian adults with congenital heart disease in relation to complexity, diagnosis, sex and age. Nutr Metab Cardiovasc Dis. 2019 Apr;29(4):367-377. doi: 10.1016/j.numecd.2019.01.009. Epub 2019 Jan 29. PMID: 30795994.</p> <p>This is the abstract:</p> <p><strong>Background and aims: </strong>Adults with congenital heart disease (ACHD) are at risk of overweight and obesity, two major health problems, though underweight can be a negative prognostic factor too. Awareness of the body mass index (BMI) in ACHD is very limited. The present study describes the use and prevalence of BMI in Italian symptomatic hospitalized ACHD patients in relation to complexity by Bethesda system classification, diagnosis, sex and age.</p> <p><strong>Methods and results: </strong>We classified 1388 ACHD patients, aged 18-69 years, on the basis of their BMI, and compared them to the Italian reference population. In our total ACHD population we found a significantly higher prevalence of underweight compared to the Italian reference population (6.34% vs 3.20%). ACHD women were more underweight than men. Underweight decreased with age. Overweight was significantly less frequent in the total ACHD population (26.73% compared to 31.70%) in the Italian reference population. Men were more likely to be overweight than women. In statistical terms obesity was similar in the Italian reference population (10.50%) and our ACHD population (9.58%). Both overweight and obesity increased with age. Results were comparable using a diagnostic anatomical-functional classification and the Bethesda system classification.</p> <p><strong>Conclusions: </strong>In our cohort of ACHD the prevalence of underweight was double that of the Italian reference population. The prevalence of overweight was lower, while obesity was similar. Since BMI does not account for differences in body fat distribution, a future aim will be to quantify the visceral component of the adipose tissue in ACHD patients and examine their body composition in order to reflect their risk of acquired cardiovascular disease better, and either to maintain or achieve an adequate visceral component.</p>
Data set from the article Lo Rito M, Grandinetti M, Muzio G, Varrica A, Frigiola A, Micheletti A, Chessa M, Giamberti A. Results for tricuspid valve surgery in adults with congenital heart disease other than Ebstein's anomaly†. Eur J Cardiothorac Surg. 2019 Oct 1;56(4):706-713. doi: 10.1093/ejcts/ezz093. PMID: 30919906.
<p>Data set from the article Lo Rito M, Grandinetti M, Muzio G, Varrica A, Frigiola A, Micheletti A, Chessa M, Giamberti A. Results for tricuspid valve surgery in adults with congenital heart disease other than Ebstein's anomaly†. Eur J Cardiothorac Surg. 2019 Oct 1;56(4):706-713. doi: 10.1093/ejcts/ezz093. PMID: 30919906.</p> <p>This is the abstract:</p> <p><strong>Objectives: </strong>Tricuspid valve (TV) surgery in the adult with congenital heart disease (ACHD) is a frequently performed procedure. The aim of this study was to analyse postoperative and medium-term outcomes.</p> <p><strong>Methods: </strong>We conducted a single-centre retrospective study of patients with ACHD who underwent TV surgery (January 2000-December 2016); patients with Ebstein's anomalies were excluded. Operative and clinical records were reviewed. Outcomes considered were survival, grade of insufficiency/stenosis and TV reoperation at follow-up.</p> <p><strong>Results: </strong>A total of 128 patients with ACHD had TV surgery for functional regurgitation (n = 95), dysplasia (n = 23) and systemic TV (n = 10). Median age was 40.8 years [interquartile range (IQR) 25.3]; 55.5% were men. Preoperative regurgitation was classified as mild (n = 8), moderate (n = 47) and severe (n = 70). The TV was repaired in 109 as follows: ring annuloplasty (n = 43), de Vega annuloplasty (n = 29), Wooler annuloplasty (n = 13), commissural plasty (n = 9), Kay annuloplasty (n = 7) and others (n = 8). The TV was replaced in 19 patients with biological (n = 10) and mechanical (n = 9) prostheses. The median hospital stay was 12 days (IQR 10). The overall mortality rate was 8.6% (n = 11): 2 hospital deaths (1.6%) and 9 late deaths. Survival was 93% [95% confidence interval (CI) 85-97%] at 5 years and 83% (95% CI 70-91%) at 10 years. The median follow-up period was 4.95 years (IQR 7.7) with 1 TV reoperation. Echocardiographic assessment showed ≥moderate regurgitation in 34 (34.3%) patients. Suture plasty had a significantly higher incidence of TV regurgitation ≥moderate compared to ring annuloplasty (48.9% vs 26.3%; P = 0.033).</p> <p><strong>Conclusions: </strong>TV surgery in the ACHD is frequently associated with other main procedures. Stabilizing the TV annulus with a prosthetic ring guarantees lower recurrence of moderate to severe regurgitation compared to suture plasty repair.</p>
Data set from the article Giamberti A, Chessa M, Chiarello C, Cipriani A, Carotti A, Galletti L, Gargiulo G, Marianeschi SM, Pace Napoleone C, Padalino M, Perri G, Luciani GB. Italian survey on cardiac surgery for adults with congenital heart disease: which surgery, where and by whom? Interact Cardiovasc Thorac Surg. 2019 Mar 25:ivz045. doi: 10.1093/icvts/ivz045. Epub ahead of print. PMID: 30907407.
<p>Data set from the article Giamberti A, Chessa M, Chiarello C, Cipriani A, Carotti A, Galletti L, Gargiulo G, Marianeschi SM, Pace Napoleone C, Padalino M, Perri G, Luciani GB. Italian survey on cardiac surgery for adults with congenital heart disease: which surgery, where and by whom? Interact Cardiovasc Thorac Surg. 2019 Mar 25:ivz045. doi: 10.1093/icvts/ivz045. Epub ahead of print. PMID: 30907407.</p> <p>This is the abstract</p> <p><strong>Objectives: </strong>The population of ageing adults with congenital heart disease (ACHD) is increasing; surgery in these patients presents major difficulties in management. A great debate has developed about whether these patients should be cared for at an adult or paediatric hospital and by an acquired or congenital cardiac surgeon. We analysed data of the surgical treatment of ACHD from the Italian cardiac surgery centres in 2016, focusing on the type of surgery performed, where these patients were operated on and by whom.</p> <p><strong>Methods: </strong>Ninety-two Italian cardiac surgery centres were contacted and 70 centres participated in this study. We collected data on the types of cardiac operations performed in congenital heart defect patients older than 18 years. In 2016, a total of 913 patients with ACHD were operated on: 440 by congenital cardiac surgeons (group I) in centres with paediatric and adult cardiac surgery units, and 473 by adult cardiac surgeons (group II) in centres with exclusively adult cardiac surgery units.</p> <p><strong>Results: </strong>Pathologies of the right ventricular outflow tract were the most frequent diseases treated in group I and pathologies of the left ventricular outflow tract in group II. Group I included more complex and heterogeneous cases than group II. Surgery for ACHD represented 12% of the activity of congenital cardiac surgeons and only 1% of the activity of adult cardiac surgeons.</p> <p><strong>Conclusions: </strong>In Italy, ACHD patients are operated on both by congenital and adult cardiac surgeons. Congenital cardiac surgeons working in centres with both paediatric and adult cardiac surgery are more involved with ACHD patients and with more complex cases.</p>
Data set from Sluman MA, Apers S, Sluiter JK, Nieuwenhuijsen K, Moons P, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Yang HL, Jackson JL, Khairy P, Cook SC, Subramanyan R, Alday L, Eriksen K, Dellborg M, Berghammer M, Mattsson E, Mackie AS, Menahem S, Caruana M, Gosney K, Soufi A, Fernandes SM, White KS, Callus E, Kutty S, Bouma BJ, Mulder BJM; APPROACH-IS consortium, the International Society for Adult Congenital Heart Disease (ISACHD). Education as important predictor for successful employment in adults with congenital heart disease worldwide. Congenit Heart Dis. 2019 May;14(3):362-371. doi: 10.1111/chd.12747. Epub 2019 Feb 4. PMID: 30714326; PMCID: PMC6849520.
<p>Data set from Sluman MA, Apers S, Sluiter JK, Nieuwenhuijsen K, Moons P, Luyckx K, Kovacs AH, Thomet C, Budts W, Enomoto J, Yang HL, Jackson JL, Khairy P, Cook SC, Subramanyan R, Alday L, Eriksen K, Dellborg M, Berghammer M, Mattsson E, Mackie AS, Menahem S, Caruana M, Gosney K, Soufi A, Fernandes SM, White KS, Callus E, Kutty S, Bouma BJ, Mulder BJM; APPROACH-IS consortium, the International Society for Adult Congenital Heart Disease (ISACHD). Education as important predictor for successful employment in adults with congenital heart disease worldwide. Congenit Heart Dis. 2019 May;14(3):362-371. doi: 10.1111/chd.12747. Epub 2019 Feb 4. PMID: 30714326; PMCID: PMC6849520.</p> <p> </p> <p>This is the abstract:</p> <p><strong>Background: </strong>Conflicting results have been reported regarding employment status and work ability in adults with congenital heart disease (CHD). Since this is an important determinant for quality of life, we assessed this in a large international adult CHD cohort.</p> <p><strong>Methods: </strong>Data from 4028 adults with CHD (53% women) from 15 different countries were collected by a uniform survey in the cross-sectional APPROACH International Study. Predictors for employment and work limitations were studied using general linear mixed models.</p> <p><strong>Results: </strong>Median age was 32 years (IQR 25-42) and 94% of patients had at least a high school degree. Overall employment rate was 69%, but varied substantially among countries. Higher education (OR 1.99-3.69) and having a partner (OR 1.72) were associated with more employment; female sex (OR 0.66, worse NYHA functional class (OR 0.67-0.13), and a history of congestive heart failure (OR 0.74) were associated with less employment. Limitations at work were reported in 34% and were associated with female sex (OR 1.36), increasing age (OR 1.03 per year), more severe CHD (OR 1.31-2.10), and a history of congestive heart failure (OR 1.57) or mental disorders (OR 2.26). Only a university degree was associated with fewer limitations at work (OR 0.62).</p> <p><strong>Conclusions: </strong>There are genuine differences in the impact of CHD on employment status in different countries. Although the majority of adult CHD patients are employed, limitations at work are common. Education appears to be the main predictor for successful employment and should therefore be encouraged in patients with CHD.</p> <p> </p>
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