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Dataset results
651 results for “autophagy”
A Phase Ib/II Study Confirmed Inhibition of Autophagy Synergizes Anti-tumor Effect of High Dose CDK4/6i
ClinicalTrials.gov study NCT05953350. IPD Sharing: NO. Countries: 1. Publications: 1.
Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo
ClinicalTrials.gov study NCT06410898. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effects of Phytocannabinoids on Immune Response and Autophagy During Chronic Immune-mediated Inflammatory Diseases
ClinicalTrials.gov study NCT06842316. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients
ClinicalTrials.gov study NCT05306249. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Autophagy Bladder Cancer
ClinicalTrials.gov study NCT03254888. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Transcriptional profiling of the response to starvation and fattening reveals differential regulation of autophagy genes in mammals
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Data from: Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy
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Data from: Acute, delayed and chronic remote ischemic conditioning is associated with downregulation of mTOR and enhanced autophagy signaling
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Data for: Quantitative analysis of autophagy reveals the role of ATG9 and ATG2 in autophagosome formation
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Immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers
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Data from: Brassinosteroids act as a positive regulator of NBR1-dependent selective autophagy in response to chilling stress in tomato
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Ribosome profiling reveals a functional role for autophagy in protein translational control
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Data from: HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels
A fundamental question is how autophagosome formation is regulated. Here we show that the PX domain protein HS1BP3 is a negative regulator of autophagosome formation. HS1BP3 depletion increased the formation of LC3-positive autophagosomes and degradation of cargo both in human cell culture and in zebrafish. HS1BP3 is localized to ATG16L1- and ATG9-positive autophagosome precursors and we show that HS1BP3 binds phosphatidic acid (PA) through its PX domain. Furthermore, we find the total PA content of cells to be significantly upregulated in the absence of HS1BP3, as a result of increased activity of the PA-producing enzyme phospholipase D (PLD) and increased localization of PLD1 to ATG16L1-positive membranes. We propose that HS1BP3 regulates autophagy by modulating the PA content of the ATG16L1-positive autophagosome precursor membranes through PLD1 activity and localization. Our findings provide key insights into how autophagosome formation is regulated by a novel negative-feedback mechanism on membrane lipids.
Figure 1: autophagy flux in RUBCN KOs [FINAL]
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fluorescence quantification associated with manuscript (Autophagy preferentially degrades non-fibrillar polyQ aggregates https://doi.org/10.1101/2023.08.08.552291 )
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tomogram quantification related to manuscript (Autophagy preferentially degrades non-fibrillar polyQ aggregates) https://doi.org/10.1101/2023.08.08.552291
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DNMT1 and autophagy
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Fig. 1 in Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Fig. 1. Chemical structures of 1–9 from the leaves of A. rugosa.
Fig. 3 in Unique guanidine-conjugated catechins from the leaves of Alchornea rugosa and their autophagy modulating activity
Fig. 3. Key NOESY correlations for sugar moieties of compounds 1–3 and 7.
LPD+α-ketoacids on Autophagy and Improving Muscle Wasting in CKD
ClinicalTrials.gov study NCT02568020. IPD Sharing: NO. Countries: 0. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.