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Dataset results
58 results for “bed rest;”
Effects of 60-day-6° Head-down Bed Rest on Cartilage and Function of the Knee Joint
ClinicalTrials.gov study NCT06612372. IPD Sharing: NO. Countries: 1. Publications: 0.
Rest Easy: Is Bed Rest Really Necessary After Surgical Repair of an Ankle Fracture?
ClinicalTrials.gov study NCT00690651. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immediate Ambulation Versus Short-time Bed Rest in Sub-fertile Women Undergoing Embryo Transfer
ClinicalTrials.gov study NCT05148624. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of Short-term Bed Rest on Cardiac Function Measured by Cardiac Magnetic Resonance Imaging
ClinicalTrials.gov study NCT06644872. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Impact of Energy Density on Energy Intake During Bed Rest
ClinicalTrials.gov study NCT06571877. IPD Sharing: NO. Countries: 1. Publications: 0.
The Z Stitch Early Bed Rest Assessment Study
ClinicalTrials.gov study NCT06087497. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effects of Music on the Anxiety and Sleep Quality of Pregnant Women on Bed Rest for a High-risk Pregnancy
ClinicalTrials.gov study NCT05316415. IPD Sharing: NO. Countries: 1. Publications: 0.
Relaxation Interventions for Pre-term Mothers on Hospitalized Bed-Rest
ClinicalTrials.gov study NCT03419065. IPD Sharing: NO. Countries: 1. Publications: 0.
Gene expression in skeletal muscle in older individuals subject to ten days of complete bed rest.
GEO Series GSE126865. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Woman skeletal muscle transcriptome with bed rest and countermeasures.
GEO Series GSE14798. Homo sapiens. 170 samples. Type: Expression profiling by array.
Muscle transcriptome response to 84-day bed rest with and without resistance exercise in men: the search for the residual signature of muscle atrophy
GEO Series GSE148152. Homo sapiens. 41 samples. Type: Expression profiling by array.
Controls over particle motion and resting times of coarse bed load transport in a glacier-fed mountain stream
<p>Field data bedload monitorning in the Estero Morales</p>
Bed Rest After Preterm Premature Rupture of the Membranes
ClinicalTrials.gov study NCT03814278. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Prolonged Bed Rest Versus Early Raising in Vertebral Osteomyelitis
ClinicalTrials.gov study NCT04735081. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
ClinicalTrials.gov study NCT03877822. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of a nutritional supplement in older individuals subject to ten days of complete bed rest.
GEO Series GSE130722. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Woman skeletal muscle transcriptome with bed rest and countermeasures.
Microgravity has a dramatic impact on human physiology illustrated in particular with skeletal muscle impairment. A thorough understanding of the mechanisms leading to loss of muscle mass and structural disorders is necessary for the definition of efficient clinical and spaceflight countermeasures. We investigated the effects of long-term bed rest on transcriptome of soleus (SOL) and vastus lateralis (VL) muscles in healthy women (BRC group n=8) and the potential beneficial impact of protein supplementation (BRN group n=8) and of a combined resistance and aerobic training (BRE group n=8). Gene expression profiles were obtained using an in-house made microarray containing 6681 muscles-relevant genes. A two-class statistical analysis was applied on the 2103 genes with consolidated expression. We identified 472 and 207 modified genes respectively for SOL and VL in BRC group. Further clustering approaches identifying relevant biological mechanisms or pathways underlined five main subclusters. Three are composed almost of upregulated genes involved mainly in nucleic acid and protein metabolism and two composed almost of downregulated genes involved in energy metabolism. Exercise countermeasure demonstrated a drastic compensatory effect decreasing the number of differentially-expressed genes by 89 and 96% in SOL and VL. In contrast nutrition countermeasure had a moderate effect and decreased the number of differentially-expressed genes by 40 and 25% in SOL and VL. Our results allowed reporting a systematic global and comprehensive view of long-term woman muscle atrophy and brought new lights and insights for space environment and for women who undergo a long-term clinical bed rest. Biological samples were collected from Pre- and Post- bed rest (BR) soleus and vastus lateralis biopsies of each subject from the three groups (bed rest only: BRC; Exercise: BRE; Nutrition: BRN). six technical replicate values (2 duplicate hybridizations a et b to chips with triplicate spots xxx) were obtained for each skeletal muscle sample. Thus for each subject 12 expression measurements (6 before BR and 6 after BR) were obtained for each muscle.
Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544.
<p>Data set from Barbic F, Heusser K, Minonzio M, Shiffer D, Cairo B, Tank J, Jordan J, Diedrich A, Gauger P, Zamuner RA, Porta A, Furlan R. Effects of Prolonged Head-Down Bed Rest on Cardiac and Vascular Baroreceptor Modulation and Orthostatic Tolerance in Healthy Individuals. Front Physiol. 2019 Aug 23;10:1061. doi: 10.3389/fphys.2019.01061. PMID: 31507438; PMCID: PMC6716544.</p> <p> </p> <p>This is the abstract:</p> <p>Orthostatic intolerance commonly occurs after prolonged bed rest, thus increasing the risk of syncope and falls. Baroreflex-mediated adjustments of heart rate and sympathetic vasomotor activity (muscle sympathetic nerve activity - MSNA) are crucial for orthostatic tolerance. We hypothesized that prolonged bed rest deconditioning alters overall baroreceptor functioning, thereby reducing orthostatic tolerance in healthy volunteers. As part of the European Space Agency Medium-term Bed Rest protocol, 10 volunteers were studied before and after 21 days of -6° head down bed rest (HDBR). In both conditions, subjects underwent ECG, beat-by-beat blood pressure, respiratory activity, and MSNA recordings while supine (REST) and during a 15-min 80° head-up tilt (TILT) followed by a 3-min -10 mmHg stepwise increase of lower body negative pressure to pre-syncope. Cardiac baroreflex sensitivity (cBRS) was obtained in the time (sequence method) and frequency domain (spectrum and cross-spectrum analyses of RR interval and systolic arterial pressure - SAP, variability). Baroreceptor modulation of sympathetic discharge activity to the vessels (sBRS) was estimated by the slope of the regression line between the percentage of MSNA burst occurrence and diastolic arterial pressure. Orthostatic tolerance significantly decreased after HDBR (12 ± 0.6 min) compared to before (21 ± 0.6 min). While supine, heart rate, SAP, and cBRS were unchanged before and after HDBR, sBRS gain was slightly depressed after than before HDBR (sBRS: -6.0 ± 1.1 versus -2.9 ± 1.5 burst% × mmHg<sup>-1</sup>, respectively). During TILT, HR was higher after than before HDBR (116 ± 4 b/min versus 100 ± 4 b/min, respectively), SAP was unmodified in both conditions, and cBRS indexes were lower after HDBR (<em>α</em> index: 3.4 ± 0.7 ms/mmHg; BRS<sub>SEQ</sub> 4.0 ± 1.0) than before (<em>α</em> index: 6.4 ± 1.0 ms/mmHg; BRS<sub>SEQ</sub> 6.8 ± 1.2). sBRS gain was significantly more depressed after HDBR than before (sBRS: -2.3 ± 0.7 versus -4.4 ± 0.4 burst% × mmHg<sup>-1</sup>, respectively). Our findings suggest that baroreflex-mediated adjustments in heart rate and MSNA are impaired after prolonged bed rest. The mechanism likely contributes to the decrease in orthostatic tolerance.</p> <p> </p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.