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1,052
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1,052 results for “cardiomyocytes”
Beta-blocker Administration for Cardiomyocyte Division
ClinicalTrials.gov study NCT04713657. IPD Sharing: NO. Countries: 1. Publications: 1.
Cardiomyocyte Injury Following Acute Ischemic Stroke
ClinicalTrials.gov study NCT03892226. IPD Sharing: NO. Countries: 1. Publications: 6.
Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte
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A targeted metabolomics-based assay using human induced pluripotent stem cell-derived cardiomyocytes identifies structural and functional cardiotoxicity potential
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Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
Cardiomyocytes from human induced pluripotent stem cells (hiPSC-CMs) are increasingly recognized as valuable for determining the effects of drugs on ion channels but they do not always accurately predict contractile responses of the human heart. This is in part attributable to their immaturity but the sensitivity of measurement tools may also be limiting. Measuring action potential, calcium flux or contraction individually misses critical information that is captured when interrogating the complete excitation-contraction coupling cascade simultaneously. Here, we develop an hypothesis-based statistical algorithm that identifies mechanisms of action. We design and build a high-speed optical system to measure action potential, cytosolic calcium and contraction simultaneously using fluorescent sensors. These measurements are automatically processed, quantified and then assessed by the algorithm. Multiplexing these three critical physical features of hiPSC-CMs allows identification of all major drug classes affecting contractility with detection sensitivities higher than individual measurement of action potential, cytosolic calcium or contraction.
Data from: Cardiomyocyte mechanodynamics under conditions of actin remodelling
The mechanical performance of cardiomyocytes is an important indicator of their maturation state and of primary importance for the development of therapies based on cardiac stem-cells. As the mechanical analysis of adherent cells at high-throughput remains challenging, we explore the applicability of real-time deformability cytometry (RT-DC) to probe cardiomyocytes in suspension. RT-DC is a microfluidic technology allowing for real-time mechanical analysis of thousands of cells with a throughput exceeding 1,000 cells per second. For cardiomyocytes derived from human induced pluripotent stem cells, we determined a Young's modulus of 1.250.08 kPa which is in close range to previous reports. Upon challenging the cytoskeleton with cytochalasin D (CytoD) to induce filamentous actin depolymerization, we distinguish three different regimes in cellular elasticity. Transitions are observed below 10 nM and above 103 nM and are characterized by a decrease in the Young's modulus. These regimes can be linked to cytoskeletal and sarcomeric actin contributions by cardiomyocyte contractility measurements at varying CytoD concentrations, where we observe a significant reduction in pulse duration only above 103 nM while no change is found for compound exposure at lower concentrations. Comparing our results to mechanical cell measurements using atomic force microscopy we demonstrate for the first time the feasibility of using a microfluidic technique to measure mechanical properties of large samples of adherent cells while linking our results to the composition of the cytoskeletal network.
Proteomics Data for "Adult human cardiomyocyte mechanics in osteogenesis imperfecta"
<p>Proteomics Data for "Adult human cardiomyocyte mechanics in osteogenesis imperfecta"</p>
Data from: Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes
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Data from: Expression profiling of human pluripotent stem cell-derived cardiomyocytes exposed to doxorubicin—integration and visualization of multi-omics data
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Data from: Cardiomyocyte mechanodynamics under conditions of actin remodelling
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Data from: Spectroscopic analysis of myoglobin and cytochrome c dynamics in isolated cardiomyocytes during hypoxia and reoxygenation
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Data from: Pacemaker translocations and power laws in 2D stem cell-derived cardiomyocyte cultures
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Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function
With extended stays aboard the International Space Station (ISS) becoming commonplace there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) to study the effects of microgravity on cell-level cardiac function and gene expression. The hiPSC-CMs were cultured aboard the ISS for 5.5 weeks and their gene expression structure and functions were compared to ground control hiPSC-CMs. Exposure to microgravity on the ISS caused alterations in hiPSC-CM calcium handling. RNA-sequencing analysis demonstrated 2,635 genes were differentially expressed among flight post-flight and ground control samples including genes involved in mitochondrial metabolism. This study represents the first use of hiPSCs to model the effects of spaceflight on human cardiomyocyte structure and function.
Human pluripotent stem cell-derived cardiomyocyte maturation both in vivo and in vitro
GEO Series GSE190758. Homo sapiens; Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing.
Gene expression analysis comparing rat neonatal cardiomyocytes and human iPSC-cardiomyocytes
GEO Series GSE225707. Homo sapiens; Rattus norvegicus. 36 samples. Type: Expression profiling by high throughput sequencing.
ZNFX1 suppresses apoptosis-associated mRNA stability in cardiomyocyte to protect against myocardial infarction (hypoxia)
GEO Series GSE273385. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Cardiomyocyte mRNA Content
GEO Series GSE119743. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation
GEO Series GSE152181. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of XBP1S and ATF6N cardiomyocytes
GEO Series GSE197965. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA sequencing identifies differentially expressed genes in embryonic cardiomyocytes following knockdown of DNMT3a or DNMT3b expression
GEO Series GSE77514. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.